Skip to main content
PMC home page
Clinical and Experimental Immunology logoLink to Clinical and Experimental Immunology
. 1977 Aug;29(2):256–260.

Experimental autoimmune thyroiditis in the vervet monkey.

D J Pudifin, J Duursma, P Brain
PMCID: PMC1541107  PMID: 409579

Abstract

Autoimmune thyroiditis was induced in two vervet monkeys by immunizing them with human thyroid extract. As expected, both animals developed cytotoxic antibodies which were active against human thyroid and other human cells in tissue culture. In addition, a second serum factor was detected. This was capable of sensitizing human thyroid (and other) cells and rendering them susceptible to killing by normal lymphocytes. This finding implicates antibody-dependent cell-mediated cytotoxicity in the pathogenesis of autoimmune thyroiditis.

Full text

PDF
256

Images in this article

257Fig. 1
on p.257

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BEUTNER E. H., WITEBSKY E. STUDIES ON ORGAN SPECIFICITY. XV. IMMUNOHISTOLOGIC EVALUATION OF REACTIONS PRODUCED BY THYROID AUTOANTIBODIES. J Immunol. 1963 Aug;91:204–209. [PubMed] [Google Scholar]
  2. Brain P., Gordon J., Willetts W. A. Rosette formation by peripheral lymphocytes. Clin Exp Immunol. 1970 May;6(5):681–688. [PMC free article] [PubMed] [Google Scholar]
  3. Calder E. A., Penhale W. J., McLeman D., Barnes E. W., Irvine W. J. Lymphocyte-dependent antibody-mediated cytotoxicity in Hashimoto thyroiditis. Clin Exp Immunol. 1973 Jun;14(2):153–158. [PMC free article] [PubMed] [Google Scholar]
  4. Clinton B. A., Weigle W. E. Cellular events during the induction of experimental thyroiditis in the rabbit. J Exp Med. 1972 Dec 1;136(6):1605–1615. doi: 10.1084/jem.136.6.1605. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. IRVINE W. J. The cytotoxic factor in thyroid disease. Scott Med J. 1960 Dec;5:511–522. doi: 10.1177/003693306000501202. [DOI] [PubMed] [Google Scholar]
  6. Irvine W. J. Studies on the Cytotoxic Factor in Thyroid Disease. Br Med J. 1962 May 26;1(5290):1444–1442.4. doi: 10.1136/bmj.1.5290.1444. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. JONES H. E., ROITT I. M. Experimental auto-immune thyroiditis in the rat. Br J Exp Pathol. 1961 Dec;42:546–557. [PMC free article] [PubMed] [Google Scholar]
  8. Kite J. H., Jr, Argue H., Rose N. R. Experimental thyroiditis in the rhesus monkey. I. Cytotoxic, mixed-agglutinating and complement-fixing antibodies. Clin Exp Immunol. 1966 Apr;1(2):139–157. [PMC free article] [PubMed] [Google Scholar]
  9. MacLennan I. C., Loewi G. Effect of specific antibody to target cells on their specific and non-specific interactions with lymphocytes. Nature. 1968 Sep 7;219(5158):1069–1070. doi: 10.1038/2191069a0. [DOI] [PubMed] [Google Scholar]
  11. PULVERTAFT R. J., DONIACH D., ROITT I. M. The cytotoxic factor in Hashimoto's disease and its incidence in other thyroid diseases. Br J Exp Pathol. 1961 Oct;42:496–503. [PMC free article] [PubMed] [Google Scholar]
  12. TERPLAN K. L., WITEBSKY E., ROSE N. R., PAINE J. R., EGAN R. W. Experimental thyroiditis in rabbits, guinea pigs and dogs, following immunization with thyroid extracts of their own and of heterologous species. Am J Pathol. 1960 Feb;36:213–239. [PMC free article] [PubMed] [Google Scholar]
  13. Weigle W. O. Experimental autoimmune thyroiditis. Pathol Annu. 1973;8:329–347. [PubMed] [Google Scholar]

Articles from Clinical and Experimental Immunology are provided here courtesy of British Society for Immunology

RESOURCES