Abstract
Thirty-eight mothers and babies were assessed by the lymphocyte transformation test for their cell-mediated immune responses to Treponema pallidum and to purified protein derivative of tuberculin (PPD). All babies, including controls, appeared to be reactive when results of [3H]-thymidine incorporation were expressed as net counts per minute. This was because of high background activity, which was most marked in cells from neonates. When results were expressed as stimulation ratios, it was revealed that cells from neonates were unreactive to both antigens, even when those from their mothers were reactive. Cells from some older babies with active congenital syphilis were reactive to both antigens.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Alford R. H., Cartwright B. B., Sell S. H. Ontogeny of human cell-mediated immunity: age-related variation of in vitro infantile lymphocyte transformation. Infect Immun. 1976 Apr;13(4):1170–1175. doi: 10.1128/iai.13.4.1170-1175.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Barnetson R. S., Bjune G., Duncan M. E. Evidence for a soluble lymphocyte factor in the transplacental transmission of T-lymphocyte responses to Mycobacterium leprae. Nature. 1976 Mar 11;260(5547):150–151. doi: 10.1038/260150a0. [DOI] [PubMed] [Google Scholar]
- Bishop N. H., Miller J. N. Humoral immunity in experimental syphilis. I. The demonstration of resistance conferred by passive immunization. J Immunol. 1976 Jul;117(1):191–196. [PubMed] [Google Scholar]
- Brody J. I., Oski F. A., Wallach E. E. Neonatal lymphocyte reactivity as an indicator of intrauterine bacterial contact. Lancet. 1968 Jun 29;1(7557):1396–1398. doi: 10.1016/s0140-6736(68)91975-2. [DOI] [PubMed] [Google Scholar]
- Campbell A. C., Waller C., Wood J., Aynsley-Green A., Yu V. Lymphocyte subpopulations in the blood of newborn infants. Clin Exp Immunol. 1974 Dec;18(4):469–482. [PMC free article] [PubMed] [Google Scholar]
- Carr M. C., Stites D. P., Fudenberg H. H. Cellular immune aspects of the human fetal-maternal relationship. I. In vitro response of cord blood lymphocytes to phytohemagglutinin. Cell Immunol. 1972 Sep;5(1):21–29. doi: 10.1016/0008-8749(72)90080-9. [DOI] [PubMed] [Google Scholar]
- Leikin S., Oppenheim J. J. Differences in transformation of adult and newborn lymphocytes stimulated by antigen, antibody, and antigen-antibody complexes. Cell Immunol. 1970 Nov;1(5):468–475. doi: 10.1016/0008-8749(70)90035-3. [DOI] [PubMed] [Google Scholar]
- Pulvertaft R. J., Pulvertaft I. Spontaneous "transformation" of lymphocytes from the umbilical-cord vein. Lancet. 1966 Oct 22;2(7469):892–893. doi: 10.1016/s0140-6736(66)91986-6. [DOI] [PubMed] [Google Scholar]