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. 1977 Dec;30(3):333–337.

Brain reactivity of lymphocytotoxic antibodies in systemic lupus erythematosus with and without cerebral involvement.

B Bresnihan, M Oliver, R Grigor, G R Hughes
PMCID: PMC1541136  PMID: 606449

Abstract

A prospective clinical study of cold-reactive lymphocytotoxic antibodies in systemic lupus erythematosus has been completed. A highly significant association between serum lymphocytotoxicity and the development of cerebral manifestations was observed. While lymphocytotoxic antibodies from patients with cerebral lupus were absorbed by homogenates of human brain, those from patients who at no time had evidence of cerebral disease failed to cross-react with brain. It is suggested that subpopulations of lymphocytotoxic antibodies differ in their brain reactivity, and that one population may be causally related to the development of some of the features of cerebral lupus.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Atkins C. J., Kondon J. J., Quismorio F. P., Friou G. J. The choroid plexus in systemic lupus erythematosus. Ann Intern Med. 1972 Jan;76(1):65–72. doi: 10.7326/0003-4819-76-1-65. [DOI] [PubMed] [Google Scholar]
  2. Bluestein H. G., Zvaifler N. J. Brain-reactive lymphocytotoxic antibodies in the serum of patients with systemic lupus erythematosus. J Clin Invest. 1976 Feb;57(2):509–516. doi: 10.1172/JCI108303. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Dubois E. L., Wierzchowiecki M., Cox M. B., Weiner J. M. Duration and death in systemic lupus erythematosus. An analysis of 249 cases. JAMA. 1974 Mar 25;227(12):1399–1402. [PubMed] [Google Scholar]
  4. Golub E. S. Brain-associated theta antigen: reactivity of rabbit anti-mouse brain with mouse lymphoid cells. Cell Immunol. 1971 Aug;2(4):353–361. doi: 10.1016/0008-8749(71)90070-0. [DOI] [PubMed] [Google Scholar]
  5. Hadler N. M., Gerwin R. D., Frank M. M., Whitaker J. N., Baker M., Decker J. L. The fourth component of complement in the cerebrospinal fluid in systemic Lupus erythematosus. Arthritis Rheum. 1973 Jul-Aug;16(4):507–521. doi: 10.1002/art.1780160411. [DOI] [PubMed] [Google Scholar]
  6. Lee P., Urowitz M. B., Bookman A. A., Koehler B. E., Smythe H. A., Gordon D. A., Ogryzlo M. A. Systemic lupus erythematosus. A review of 110 cases with reference to nephritis, the nervous system, infections, aseptic necrosis and prognosis. Q J Med. 1977 Jan;46(181):1–32. [PubMed] [Google Scholar]
  7. Mittal K. K., Mickey M. R., Singal D. P., Terasaki P. I. Serotyping for homotransplantation. 18. Refinement of microdroplet lymphocyte cytotoxicity test. Transplantation. 1968 Nov;6(8):913–927. doi: 10.1097/00007890-196811000-00006. [DOI] [PubMed] [Google Scholar]
  8. Mittal K. K., Rossen R. D., Sharp J. T., Lidsky M. D., Butler W. T. Lymphocyte cytotoxic antibodies in systemic lupus erythematosus. Nature. 1970 Mar 28;225(5239):1255–1256. doi: 10.1038/2251255a0. [DOI] [PubMed] [Google Scholar]
  9. Parker L. M., Chused T. M., Steinberg A. D. Immunofluorescence studies on thymocytotoxic antibody from New Zealand Black mice. J Immunol. 1974 Jan;112(1):285–292. [PubMed] [Google Scholar]
  10. REIF A. E., ALLEN J. M. THE AKR THYMIC ANTIGEN AND ITS DISTRIBUTION IN LEUKEMIAS AND NERVOUS TISSUES. J Exp Med. 1964 Sep 1;120:413–433. doi: 10.1084/jem.120.3.413. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Shirai T., Mellors R. C. Natural cytotoxic autoantibody against thymocytes in NZB mice. Clin Exp Immunol. 1972 Sep;12(1):133–152. [PMC free article] [PubMed] [Google Scholar]
  12. Stastny P., Ziff M. Antibodies against cell membrane constituents in systemic lupus erythematosus and related diseases. I. Cytotoxic effect of serum from patients with systemic lupus erythematosus (SLE) for allogeneic and for autologous lymphocytes. Clin Exp Immunol. 1971 Apr;8(4):543–550. [PMC free article] [PubMed] [Google Scholar]
  13. Terasaki P. I., Mottironi V. D., Barnett E. V. Cytotoxins in disease. Autocytotoxins in lupus. N Engl J Med. 1970 Oct 1;283(14):724–728. doi: 10.1056/NEJM197010012831403. [DOI] [PubMed] [Google Scholar]
  14. Van den Noort S., Stjernholm R. L. Lymphotoxic activity in multiple sclerosis serum. Neurology. 1971 Aug;21(8):783–793. doi: 10.1212/wnl.21.8.783. [DOI] [PubMed] [Google Scholar]
  15. Winfield J. B., Winchester R. J., Wernet P., Fu S. M., Kunkel H. G. Nature of cold-reactive antibodies to lymphocyte surface determinants in systemic lupus erythematosus. Arthritis Rheum. 1975 Jan-Feb;18(1):1–8. doi: 10.1002/art.1780180101. [DOI] [PubMed] [Google Scholar]

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