Abstract
The course of infection with Leishmania donovani was followed in seven strains of laboratory mice with measurement of the liver parasite burdens over 20 weeks. The acute parasite population growth rate varied greatly between, but not within, strains. Four strains were relatively resistant with less than an eight-fold increase while the three acutely susceptible strains showed over an eight-fold increase in the first month. Thereafter, one initially susceptible strain showed a dramatic fall in parasite numbers with histological liver damage while another strain maintained an immense parasite load for up to 2 years involving mononuclear phagocytes throughout the body. The system provides a model for studying genetic control of resistance to intracellular infection and the range of responses is compared with human leprosy and cutaneous leishmaniasis.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BRAY R. S., GARNHAM P. C. The Giemsa-colophonium method for staining protozoa in tissue sections. Indian J Malariol. 1962 Jun;16:153–155. [PubMed] [Google Scholar]
- Bradley D. J., Poole J. C., Lamb R. M. Some observations on chronic visceral leishmaniasis of the mouse. Trans R Soc Trop Med Hyg. 1973;67(1):21–22. doi: 10.1016/0035-9203(73)90285-x. [DOI] [PubMed] [Google Scholar]
- Bryceson A. D., Bray R. S., Wolstencroft R. A., Dumonde D. C. Immunity in cutaneous leishmaniasis of the guinea-pig. Clin Exp Immunol. 1970 Sep;7(3):301–341. [PMC free article] [PubMed] [Google Scholar]
- Bryceson A. D. Diffuse cutaneous leishmaniasis in Ethiopia. I. The clinical and histological features of the disease. Trans R Soc Trop Med Hyg. 1969;63(6):708–737. doi: 10.1016/0035-9203(69)90116-3. [DOI] [PubMed] [Google Scholar]
- Ott K. J., Stauber L. A. Eperythrozoon coccoides: influence on course of infection of Plasmodium chabaudi in mouse. Science. 1967 Mar 24;155(3769):1546–1548. doi: 10.1126/science.155.3769.1546. [DOI] [PubMed] [Google Scholar]
- PETERS W. COMPETITIVE RELATIONSHIP BETWEEN EPERYTHROZOON COCCOIDES AND PLASMODIUM BERGHEI IN THE MOUSE. Exp Parasitol. 1965 Apr;16:158–166. doi: 10.1016/0014-4894(65)90039-1. [DOI] [PubMed] [Google Scholar]
- PHILIPPE E., CHADLI A. [Experimental leishmaniasis in the mouse (Leishmania donovani and Leishmania tropica)]. Arch Inst Pasteur Tunis. 1961 Dec;38:241–254. [PubMed] [Google Scholar]
- Preston P. M., Carter R. L., Leuchars E., Davies A. J., Dumonde D. C. Experimental cutaneous leishmaniasis. 3. Effects of thymectomy on the course of infection of CBA mice with Leishmania tropica. Clin Exp Immunol. 1972 Feb;10(2):337–357. [PMC free article] [PubMed] [Google Scholar]
- Turk J. L., Bryceson A. D. Immunological phenomena in leprosy and related diseases. Adv Immunol. 1971;13:209–266. doi: 10.1016/s0065-2776(08)60185-6. [DOI] [PubMed] [Google Scholar]