Abstract
Leucocyte and lymphocyte counts, the distribution of erythrocyte rosette-forming cells (E-RFC), erythrocyte-antibody-complement rosette-forming cells (EAC-RFC), cells bearing surface membrane immunoglobulin (SMIg), latex-ingesting cells and the PHA stimulation index of lymphocytes were evaluated in both pregnant and non-pregnant women. In the gravid female leucocytosis due to neutrophilia is seen, and the PHA-induced transformation of maternal lymphocytes in the absence of autologous plasma remains unaltered. There was a rise in the percentage of EAC-RFC and cells bearing SMIg during a pregnancy, but after monocyte adsorption on plastic dishes of the mononuclear cells, obtained after Ficoll-Hypapue centrifugation, this increase is abolished. There is a significant increase of the number of latex-ingesting cells during pregnancy. These findings indicate a significant increase of the monocytes during pregnancy.
Full text
PDF




Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- ANDREWS W. C., BONSNES R. W. The leucocytes during pregnancy. Am J Obstet Gynecol. 1951 May;61(5):1129–1135. doi: 10.1016/0002-9378(51)90315-8. [DOI] [PubMed] [Google Scholar]
- Ablin R. J., Bruns G. R., Guinan P., Bush I. M. The effect of estrogen on the incorporation of 3H-thymidine by PHA-stimulated human peripheral blood lymphocytes. J Immunol. 1974 Aug;113(2):705–707. [PubMed] [Google Scholar]
- Baum M. Letter: Variations in leucocyte count during menstrual cycle. Br Med J. 1975 Jul 12;3(5975):102–102. doi: 10.1136/bmj.3.5975.102. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Beer A. E., Billingham R. E. The embryo as a transplant. Sci Am. 1974 Apr;230(4):36–46. doi: 10.1038/scientificamerican0474-36. [DOI] [PubMed] [Google Scholar]
- Brain P., Marston R. H., Gordon J. Immunological responses in pregnancy. Br Med J. 1972 Nov 25;4(5838):488–488. doi: 10.1136/bmj.4.5838.488-a. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bulmer R., Hancock K. W. Depletion of circulating T lymphocytes in pregnancy. Clin Exp Immunol. 1977 May;28(2):302–305. [PMC free article] [PubMed] [Google Scholar]
- Gergely P., Dzvonyàr J., Szegedi G., Fekete B., Szabò G., Petrànyi G. T and B lymphocytes in pregnancy. Klin Wochenschr. 1974 Jun 15;52(12):601–602. doi: 10.1007/BF01468504. [DOI] [PubMed] [Google Scholar]
- Han T. Human chorionic gonadotropin. Its inhibitory effect on cell-mediated immunity in vivo and in vitro. Immunology. 1975 Sep;29(3):509–515. [PMC free article] [PubMed] [Google Scholar]
- Hellström K. E., Hellström I., Brawn J. Abrogation of cellular immunity to antigenically foreign mouse embryonic cells by a serum factor. Nature. 1969 Nov 29;224(5222):914–915. doi: 10.1038/224914a0. [DOI] [PubMed] [Google Scholar]
- Junge U., Hoekstra J., Wolfe L., Deinhardt F. Microtechnique for quantitative evaluation of in vitro lymphocyte transformation. Clin Exp Immunol. 1970 Sep;7(3):431–437. [PMC free article] [PubMed] [Google Scholar]
- Koller C. A., King G. W., Hurtubise P. E., Sagone A. L., LoBuglio A. F. Characterization of glass adherent human mononuclear cells. J Immunol. 1973 Nov;111(5):1610–1612. [PubMed] [Google Scholar]
- Koziner B., Cosimi A. B., Bloch K. J. Distribution of latex-ingesting cells, T cells, and B cells in the peripheral blood of patients with malignant melanoma. J Natl Cancer Inst. 1975 Dec;55(6):1295–1299. doi: 10.1093/jnci/55.6.1295. [DOI] [PubMed] [Google Scholar]
- Magarey C. J., Baum M. Oestrogen as a reticuloendothelial stimulant in patients with cancer. Br Med J. 1971 May 15;2(5758):367–370. doi: 10.1136/bmj.2.5758.367. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mellstedt H., Jondal M., Holm G. In vitro studies of lymphocytes from patients with plasma cell myeloma. II. Characterization by cell surface markers. Clin Exp Immunol. 1973 Nov;15(3):321–330. [PMC free article] [PubMed] [Google Scholar]
- Preud'homme J. L., Flandrin G. Identification by peroxidase staining of monocytes in surface immunofluorescence tests. J Immunol. 1974 Nov;113(5):1650–1653. [PubMed] [Google Scholar]
- Strelkauskas A. J., Wilson B. S., Dray D., Dodson M. Inversion of levels of human T and B cells in early pregnancy. Nature. 1975 Nov 27;258(5533):331–332. doi: 10.1038/258331a0. [DOI] [PubMed] [Google Scholar]
- Thiede H. A., Choate J. W., Dyre S. Pregnancy and the lymphocyte. Am J Obstet Gynecol. 1968 Nov 1;102(5):642–653. doi: 10.1016/0002-9378(68)90378-5. [DOI] [PubMed] [Google Scholar]
- Watkins S. M. Lymphocyte response to phytohaemagglutin in pregnancy. J Obstet Gynaecol Br Commonw. 1972 Nov;79(11):990–993. doi: 10.1111/j.1471-0528.1972.tb11876.x. [DOI] [PubMed] [Google Scholar]
- Yata J., Tsukimoto I., Tachibana T. Human lymphocyte subpopulations. Human thymus-lymphoid tissue (HTL) antigen-positive lymphocytes forming rosettes with sheep erythrocytes and HTL antigen-negative lymphocytes interacting with antigen-antibody-complement complexes. Clin Exp Immunol. 1973 Jul;14(3):319–326. [PMC free article] [PubMed] [Google Scholar]
- Zucker-Franklin D., Davidson M., Thomas L. The interaction of mycoplasmas with mammalian cells. II. Monocytes and lymphocytes. J Exp Med. 1966 Sep 1;124(3):533–542. doi: 10.1084/jem.124.3.533. [DOI] [PMC free article] [PubMed] [Google Scholar]
