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Clinical and Experimental Immunology logoLink to Clinical and Experimental Immunology
. 1978 Jan;31(1):45–49.

Distribution of mononuclear cells during pregnancy.

J Plum, M Thiery, L Sabbe
PMCID: PMC1541189  PMID: 305834

Abstract

Leucocyte and lymphocyte counts, the distribution of erythrocyte rosette-forming cells (E-RFC), erythrocyte-antibody-complement rosette-forming cells (EAC-RFC), cells bearing surface membrane immunoglobulin (SMIg), latex-ingesting cells and the PHA stimulation index of lymphocytes were evaluated in both pregnant and non-pregnant women. In the gravid female leucocytosis due to neutrophilia is seen, and the PHA-induced transformation of maternal lymphocytes in the absence of autologous plasma remains unaltered. There was a rise in the percentage of EAC-RFC and cells bearing SMIg during a pregnancy, but after monocyte adsorption on plastic dishes of the mononuclear cells, obtained after Ficoll-Hypapue centrifugation, this increase is abolished. There is a significant increase of the number of latex-ingesting cells during pregnancy. These findings indicate a significant increase of the monocytes during pregnancy.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ANDREWS W. C., BONSNES R. W. The leucocytes during pregnancy. Am J Obstet Gynecol. 1951 May;61(5):1129–1135. doi: 10.1016/0002-9378(51)90315-8. [DOI] [PubMed] [Google Scholar]
  2. Ablin R. J., Bruns G. R., Guinan P., Bush I. M. The effect of estrogen on the incorporation of 3H-thymidine by PHA-stimulated human peripheral blood lymphocytes. J Immunol. 1974 Aug;113(2):705–707. [PubMed] [Google Scholar]
  3. Baum M. Letter: Variations in leucocyte count during menstrual cycle. Br Med J. 1975 Jul 12;3(5975):102–102. doi: 10.1136/bmj.3.5975.102. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Beer A. E., Billingham R. E. The embryo as a transplant. Sci Am. 1974 Apr;230(4):36–46. doi: 10.1038/scientificamerican0474-36. [DOI] [PubMed] [Google Scholar]
  5. Brain P., Marston R. H., Gordon J. Immunological responses in pregnancy. Br Med J. 1972 Nov 25;4(5838):488–488. doi: 10.1136/bmj.4.5838.488-a. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Bulmer R., Hancock K. W. Depletion of circulating T lymphocytes in pregnancy. Clin Exp Immunol. 1977 May;28(2):302–305. [PMC free article] [PubMed] [Google Scholar]
  7. Gergely P., Dzvonyàr J., Szegedi G., Fekete B., Szabò G., Petrànyi G. T and B lymphocytes in pregnancy. Klin Wochenschr. 1974 Jun 15;52(12):601–602. doi: 10.1007/BF01468504. [DOI] [PubMed] [Google Scholar]
  8. Han T. Human chorionic gonadotropin. Its inhibitory effect on cell-mediated immunity in vivo and in vitro. Immunology. 1975 Sep;29(3):509–515. [PMC free article] [PubMed] [Google Scholar]
  9. Hellström K. E., Hellström I., Brawn J. Abrogation of cellular immunity to antigenically foreign mouse embryonic cells by a serum factor. Nature. 1969 Nov 29;224(5222):914–915. doi: 10.1038/224914a0. [DOI] [PubMed] [Google Scholar]
  10. Junge U., Hoekstra J., Wolfe L., Deinhardt F. Microtechnique for quantitative evaluation of in vitro lymphocyte transformation. Clin Exp Immunol. 1970 Sep;7(3):431–437. [PMC free article] [PubMed] [Google Scholar]
  11. Koller C. A., King G. W., Hurtubise P. E., Sagone A. L., LoBuglio A. F. Characterization of glass adherent human mononuclear cells. J Immunol. 1973 Nov;111(5):1610–1612. [PubMed] [Google Scholar]
  12. Koziner B., Cosimi A. B., Bloch K. J. Distribution of latex-ingesting cells, T cells, and B cells in the peripheral blood of patients with malignant melanoma. J Natl Cancer Inst. 1975 Dec;55(6):1295–1299. doi: 10.1093/jnci/55.6.1295. [DOI] [PubMed] [Google Scholar]
  13. Magarey C. J., Baum M. Oestrogen as a reticuloendothelial stimulant in patients with cancer. Br Med J. 1971 May 15;2(5758):367–370. doi: 10.1136/bmj.2.5758.367. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Mellstedt H., Jondal M., Holm G. In vitro studies of lymphocytes from patients with plasma cell myeloma. II. Characterization by cell surface markers. Clin Exp Immunol. 1973 Nov;15(3):321–330. [PMC free article] [PubMed] [Google Scholar]
  15. Preud'homme J. L., Flandrin G. Identification by peroxidase staining of monocytes in surface immunofluorescence tests. J Immunol. 1974 Nov;113(5):1650–1653. [PubMed] [Google Scholar]
  16. Strelkauskas A. J., Wilson B. S., Dray D., Dodson M. Inversion of levels of human T and B cells in early pregnancy. Nature. 1975 Nov 27;258(5533):331–332. doi: 10.1038/258331a0. [DOI] [PubMed] [Google Scholar]
  17. Thiede H. A., Choate J. W., Dyre S. Pregnancy and the lymphocyte. Am J Obstet Gynecol. 1968 Nov 1;102(5):642–653. doi: 10.1016/0002-9378(68)90378-5. [DOI] [PubMed] [Google Scholar]
  18. Watkins S. M. Lymphocyte response to phytohaemagglutin in pregnancy. J Obstet Gynaecol Br Commonw. 1972 Nov;79(11):990–993. doi: 10.1111/j.1471-0528.1972.tb11876.x. [DOI] [PubMed] [Google Scholar]
  19. Yata J., Tsukimoto I., Tachibana T. Human lymphocyte subpopulations. Human thymus-lymphoid tissue (HTL) antigen-positive lymphocytes forming rosettes with sheep erythrocytes and HTL antigen-negative lymphocytes interacting with antigen-antibody-complement complexes. Clin Exp Immunol. 1973 Jul;14(3):319–326. [PMC free article] [PubMed] [Google Scholar]
  20. Zucker-Franklin D., Davidson M., Thomas L. The interaction of mycoplasmas with mammalian cells. II. Monocytes and lymphocytes. J Exp Med. 1966 Sep 1;124(3):533–542. doi: 10.1084/jem.124.3.533. [DOI] [PMC free article] [PubMed] [Google Scholar]

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