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. 1978 Mar;31(3):414–418.

Differing surface marker characteristics in plasma cell dyscrasias with particular reference to IgM myeloma.

G F Burns, J C Cawley, C R Barker, C P Worman, C G Raper, F G Hayhoe
PMCID: PMC1541252  PMID: 350460

Abstract

Immunological marker studies using direct immunofluorescence and rosette methods were performed on the bone marrow and peripheral blood of an IgM myeloma, and on the peripheral blood of two cases of IgA myeloma and one IgG myeloma. These studies confirmed the peripheral blood involvement in plasma cell dyscrasias. In the IgA myeloma, the membrane and cytoplasmic immunoglobulin was restricted to IgA, and the IgG myeloma did not express immunoglobulin at the surface of the cells shown to contain cytoplasmic IgG. The IgM myeloma cells, on the other hand, expressed membrane immunoglobulin, including IgD, of a single light chain type. The majority of plasma cells secreting IgA or IgG did not express the IgG Fc receptor, but most of the cells from the IgM myeloma, including plasma cells, did express IgG Fc receptors.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bourgois A., Kitajima K., Hunter I. R., Askonas B. A. Surface immunoglobulins of lipopolysaccharide-stimulated spleen cells. The behavior of IgM, IgD and IgG. Eur J Immunol. 1977 Mar;7(3):151–153. doi: 10.1002/eji.1830070307. [DOI] [PubMed] [Google Scholar]
  2. Burns G. F., Cawley J. C., Barker C. R., Goldstone A. H., Hayhoe F. G. New evidence relating to the nature and origin of the hairy cell of leukaemic reticuloendotheliosis. Br J Haematol. 1977 May;36(1):71–84. doi: 10.1111/j.1365-2141.1977.tb05757.x. [DOI] [PubMed] [Google Scholar]
  3. Burns G. F., Cawley J. C., Flemans R. J., Higgy K. E., Worman C. P., Barker C. R., Roberts B. E., Hayhoe F. G. Surface marker and other characteristics of Gaucher's cells. J Clin Pathol. 1977 Oct;30(10):981–988. doi: 10.1136/jcp.30.10.981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Fair D. S., Schaffer S., Krueger R. G. Development of monoclonal IgA and an apparent IgG in a patient with macroglobulinemia: sharing of individually specific antigenic determinants among IgM, IgA, and IgG. J Immunol. 1976 Sep;117(3):944–949. [PubMed] [Google Scholar]
  5. Ferrarini M., Viale G., Risso A., Pernis B. A study of immunoglobulin classes present on the membrane and in the cytoplasm of human tonsil plasma cells. Eur J Immunol. 1976 Aug;6(8):562–565. doi: 10.1002/eji.1830060807. [DOI] [PubMed] [Google Scholar]
  6. Garrett J. V., Newton R. K., Scarffe J. H. Abnormal blood lymphocytes in non-Hodgkin's lymphoma. Lancet. 1977 Mar 5;1(8010):542–542. doi: 10.1016/s0140-6736(77)91399-x. [DOI] [PubMed] [Google Scholar]
  7. Hobbs J. R. Immunochemical classes of myelomatosis. Including data from a therapeutic trial conducted by a Medical Research Council working party. Br J Haematol. 1969 Jun;16(6):599–606. doi: 10.1111/j.1365-2141.1969.tb00440.x. [DOI] [PubMed] [Google Scholar]
  8. Ling N. R., Bishop S., Jefferis Use of antibody-coated red cells for the sensitive detection of antigen and in rosette tests for cells bearing surface immunoglobulins. J Immunol Methods. 1977;15(3):279–289. doi: 10.1016/0022-1759(77)90065-5. [DOI] [PubMed] [Google Scholar]
  9. Mellstedt H., Hammarström S., Holm G. Monoclonal lymphocyte population in human plasma cell myeloma. Clin Exp Immunol. 1974 Jul;17(3):371–384. [PMC free article] [PubMed] [Google Scholar]
  10. Preud'Homme J. L., Hurez D., Danon F., Brouet J. C., Seligmann M. Intracytoplasmic and surface-bound immunoglobulins in "nonsecretory" and Bence-Jones myeloma. Clin Exp Immunol. 1976 Sep;25(3):428–436. [PMC free article] [PubMed] [Google Scholar]
  11. Preud'homme J. L., Seligmann M. Immunoglobulins on the surface of lymphoid cells in Waldenström's macroglobulinemia. J Clin Invest. 1972 Mar;51(3):701–705. doi: 10.1172/JCI106858. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Ramasamy R. A fluorescent stain for viable rosette-forming cells. J Immunol Methods. 1974 Aug;5(3):305–306. doi: 10.1016/0022-1759(74)90116-1. [DOI] [PubMed] [Google Scholar]
  13. Ramasamy R., Munro A., Milstein C. Possible role for the Fc receptor on B lymphocytes. Nature. 1974 Jun 7;249(457):573–574. doi: 10.1038/249573a0. [DOI] [PubMed] [Google Scholar]

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