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. 1978 May;32(2):233–242.

Treatment of Goodpasture's disease by plasma exchange and immunosuppression.

C P Swainson, J S Robson, S J Urbaniak, A J Keller, A B Kay
PMCID: PMC1541272  PMID: 668199

Abstract

Three cases of Goodpasture's disease are described who were treated with intensive plasma exchange and immunosuppression. There was no improvement in renal function and the patients required chronic haemodialysis, but renal function did recover with treatment for recurrence of disease in a transplanted kidney. Anti-GBM antibody levels were not controlled and substantial reduction in fibrinogen and complement were only achieved with daily treatment. A controlled trial of this regime is urgently required.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. AZEN E. A., CLATANOFF D. V. PROLONGED SURVIVAL IN GOODPASTURE'S SYNDROME. Arch Intern Med. 1964 Sep;114:453–460. doi: 10.1001/archinte.1964.03860090187024. [DOI] [PubMed] [Google Scholar]
  2. BENOIT F. L., RULON D. B., THEIL G. B., DOOLAN P. D., WATTEN R. H. GOODPASTURE'S SYNDROME: A CLINICOPATHOLOGIC ENTITY. Am J Med. 1964 Sep;37:424–444. doi: 10.1016/0002-9343(64)90199-8. [DOI] [PubMed] [Google Scholar]
  3. Bloom V. R., Wayne D. J., Wrong O. M. Lung purpura and nephritis (Goodpasture's syndrome) complicated by the nephrotic syndrome. Ann Intern Med. 1965 Nov;63(5):752–759. doi: 10.7326/0003-4819-63-5-572. [DOI] [PubMed] [Google Scholar]
  4. Branda R. F., Moldow C. F., McCullough J. J., Jacob H. S. Plasma exchange in the treatment of immune disease. Transfusion. 1975 Nov-Dec;15(6):570–576. doi: 10.1046/j.1537-2995.1975.15676082232.x. [DOI] [PubMed] [Google Scholar]
  5. Cohen L. H., Wilson C. B., Freeman R. M. Goodpasture syndrome: recovery after severe renal insufficiency. Arch Intern Med. 1976 Jul;136(7):835–837. doi: 10.1001/archinte.136.7.835. [DOI] [PubMed] [Google Scholar]
  6. DUNCAN D. A., DRUMMOND K. N., MICHAEL A. F., VERNIER R. L. PULMONARY HEMORRHAGE AND GLOMERULONEPHRITIS. REPORT OS SIX CASES AND STUDY OF THE RENAL LESION BY THE FLUORESCENT ANTIBODY TECHNIQUE AND ELECTRON MICROSCOPY. Ann Intern Med. 1965 May;62:920–938. doi: 10.7326/0003-4819-62-5-920. [DOI] [PubMed] [Google Scholar]
  7. ELLIS B. C., STRANSKY A. A quick and accurate method for the determination of fibronogen in plasma. J Lab Clin Med. 1961 Sep;58:477–488. [PubMed] [Google Scholar]
  8. Eisinger A. J. Goodpasture's syndrome: failure of nephrectomy to cure pulmonary hemorrhage. Am J Med. 1973 Oct;55(3):565–570. doi: 10.1016/0002-9343(73)90215-5. [DOI] [PubMed] [Google Scholar]
  9. Hayslett J. P., Berte J. B., Kashgarian M. Successful treatment of renal failure in Goodpasture's syndrome. Arch Intern Med. 1971 May;127(5):953–957. [PubMed] [Google Scholar]
  10. Lockwood C. M., Rees A. J., Pearson T. A., Evans D. J., Peters D. K., Wilson C. B. Immunosuppression and plasma-exchange in the treatment of Goodpasture's syndrome. Lancet. 1976 Apr 3;1(7962):711–715. doi: 10.1016/s0140-6736(76)93089-0. [DOI] [PubMed] [Google Scholar]
  11. MCCALL C. B., HARRIS T. R., HATCH F. E. NON-FATAL PULMONARY HEMORRHAGE AND GLOMERULONEPHRITIS. Am Rev Respir Dis. 1965 Mar;91:424–433. doi: 10.1164/arrd.1965.91.3.424. [DOI] [PubMed] [Google Scholar]
  12. Maddock R. K., Jr, Stevens L. E., Reemtsma K., Bloomer H. A. Goodpasture's syndrome. Cessation of pulmonary hemorrhage after bilateral nephrectomy. Ann Intern Med. 1967 Dec;67(6):1258–1264. doi: 10.7326/0003-4819-67-6-1258. [DOI] [PubMed] [Google Scholar]
  13. Proskey A. J., Weatherbee L., Easterling R. E., Greene J. A., Jr, Weller J. M. Goodpasture's syndrome. A report of five cases and review of the literature. Am J Med. 1970 Feb;48(2):162–173. doi: 10.1016/0002-9343(70)90112-9. [DOI] [PubMed] [Google Scholar]
  14. RANDALL R. E., Jr, GLAZIER J. S., LIGGETT M. Nephritis with lung haemorrhage. Lancet. 1963 Mar 2;1(7279):499–499. doi: 10.1016/s0140-6736(63)92395-x. [DOI] [PubMed] [Google Scholar]
  15. RUSBY N. L., WILSON C. Lung purpura with nephritis. Q J Med. 1960 Oct;29:501–511. [PubMed] [Google Scholar]
  16. Rees A. J., Lockwood C. M., Peters D. K. Enhanced allergic tissue injury in Goodpasture's syndrome by intercurrent bacterial infection. Br Med J. 1977 Sep 17;2(6089):723–726. doi: 10.1136/bmj.2.6089.723. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Teichman S., Briggs W. A., Knieser M. R., Enquist R. W. Goodpasture's syndrome: two cases with contrasting early course and management. Am Rev Respir Dis. 1976 Feb;113(2):223–232. doi: 10.1164/arrd.1976.113.2.223. [DOI] [PubMed] [Google Scholar]
  18. Wilson C. B., Dixon F. J. Anti-glomerular basement membrane antibody-induced glomerulonephritis. Kidney Int. 1973 Feb;3(2):74–89. doi: 10.1038/ki.1973.14. [DOI] [PubMed] [Google Scholar]
  19. Wilson C. B., Smith R. C. Goodpasture's syndrome associated with influenza A2 virus infection. Ann Intern Med. 1972 Jan;76(1):91–94. doi: 10.7326/0003-4819-76-1-91. [DOI] [PubMed] [Google Scholar]

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