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. 1978 May;32(2):193–198.

Circulating soluble immume complexes in recurrent oral ulceration and Behçet's syndrome.

R J Levinsky, T Lehner
PMCID: PMC1541280  PMID: 668196

Abstract

Circulating IgG immune complexes were assayed by means of agglutination inhibition of IgG-coated latex particles to human IgG by rabbit IgM antibodies. Sera from thirty patients with Behçet's syndrome, thirty patients with recurrent oral ulcers and thirty healthy control subjects were analysed. The results showed raised levels of immune complexes in 60% of patients with Behçet's syndrome and 40% of patients with recurrent oral ulcers. There were significant differences in the levels of immune complexes between the neuro-ocular and arthritic types of Behçet's syndrome as compared with the muco-cutaneous type of Behçet's syndrome or recurrent oral ulceration. A close association was found between the disease activity and the amount of immune complexes. These results suggest that immune complexes may play a part in the transition from the epithelial involvement of mucosa or cutaneous tissues to the neuro-ocular and arthritic types of Behçet's syndrome. Another factor in tissue distribution might be the size of immune complexes, as multi-focal involvement of tissues in the neuro-ocular type of Behçet's syndrome is associated with a broad range of immune complexes from 3 X 10(5) to 3 X 10(6) daltons.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Adinolfi M., Lehner T. Acute phase proteins and C9 in patients with Behcet's syndrome and aphthous ulcers. Clin Exp Immunol. 1976 Jul;25(1):36–39. [PMC free article] [PubMed] [Google Scholar]
  2. Dolby A. E. Recurrent aphthous ulceration. Effect of sera and peripheral blood lymphocytes upon oral epithelial tissue culture cells. Immunology. 1969 Nov;17(5):709–714. [PMC free article] [PubMed] [Google Scholar]
  3. Donatsky O. Comparison of cellular and humoral immunity against streptococcal and adult human oral mucosa antigens in relation to exacerbation or recurrent aphthous stomatitis. Acta Pathol Microbiol Scand C. 1976 Aug;84(4):270–282. doi: 10.1111/j.1699-0463.1976.tb00030.x. [DOI] [PubMed] [Google Scholar]
  4. Hodgson H. J., Potter B. J., Jewell D. P. Immune complexes in ulcerative colitis and Crohn's disease. Clin Exp Immunol. 1977 Aug;29(2):187–196. [PMC free article] [PubMed] [Google Scholar]
  5. Kawachi-Takahashi S., Tanaka K., Takahashi M., Kawashima T., Shimada K. Determination of serum C9 level by immunodiffusion. Elevation in patients with infectious or allergic skin diseases. Int Arch Allergy Appl Immunol. 1975;48(2):161–170. doi: 10.1159/000231302. [DOI] [PubMed] [Google Scholar]
  6. LEHNER T. RECURRENT APHTHOUS ULCERATION AND AUTOIMMUNITY. Lancet. 1964 Nov 28;2(7370):1154–1155. doi: 10.1016/s0140-6736(64)92673-x. [DOI] [PubMed] [Google Scholar]
  7. Lehner T. Autoimmunity in oral diseases, with special reference to recurrent oral ulceration. Proc R Soc Med. 1968 May;61(5):515–524. [PMC free article] [PubMed] [Google Scholar]
  8. Lehner T. Behçet's syndrome and autoimmunity. Br Med J. 1967 Feb 25;1(5538):465–467. doi: 10.1136/bmj.1.5538.465. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Lehner T. Characterization of mucosal antibodies in recurrent aphthous ulceration and Behcet's syndrome. Arch Oral Biol. 1969 Jul;14(7):843–853. doi: 10.1016/0003-9969(69)90174-5. [DOI] [PubMed] [Google Scholar]
  10. Levinsky R. J., Cameron J. S., Soothill J. F. Serum immune complexes and disease activity in lupus nephritis. Lancet. 1977 Mar 12;1(8011):564–567. doi: 10.1016/s0140-6736(77)91998-5. [DOI] [PubMed] [Google Scholar]
  11. Levinsky R. J., Soothill J. F. A test for antigen--antibody complexes in human sera using IgM of rabbit antisera to human immunoglobulins. Clin Exp Immunol. 1977 Sep;29(3):428–435. [PMC free article] [PubMed] [Google Scholar]
  12. Rogers R. S., 3rd, Sams W. M., Jr, Shorter R. G. Lymphocytotoxicity in recurrent aphthous stomatitis. Lymphocytotoxicity for oral epithelial cells in recurrent aphthous stomatitis and Bechet syndrome. Arch Dermatol. 1974 Mar;109(3):361–363. [PubMed] [Google Scholar]
  13. SIRCUS W., CHURCH R., KELLEHER J. Recurrent aphthous ulceration of the mouth; a study of the natural history, aetiology, and treatment. Q J Med. 1957 Apr;26(102):235–249. [PubMed] [Google Scholar]
  14. Shimada K., Kogure M., Kawashima T., Nishioka K. Reduction of complement in Behçet's disease and drug allergy. Med Biol. 1974 Aug;52(4):234–239. [PubMed] [Google Scholar]
  15. Williams B. D., Lehner T. Immune complexes in Behçet's syndrome and recurrent oral ulceration. Br Med J. 1977 May 28;1(6073):1387–1389. doi: 10.1136/bmj.1.6073.1387. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Zubler R. H., Nydegger U., Perrin L. H., Fehr K., McCormick J., Lambert P. H., Miescher P. A. Circulating and intra-articular immune complexes in patients with rheumatoid arthritis. Correlation of 125I-Clq binding activity with clinical and biological features of the disease. J Clin Invest. 1976 May;57(5):1308–1319. doi: 10.1172/JCI108399. [DOI] [PMC free article] [PubMed] [Google Scholar]

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