Skip to main content
NCBI home page
Clinical and Experimental Immunology logoLink to Clinical and Experimental Immunology
. 1988 Feb;71(2):357–361.

Immunoglobulin profile of tracheal aspirate fluid in intubated children.

K Forsyth 1, L Koh 1, A Lawrence 1, J Bradley 1
PMCID: PMC1541444  PMID: 3349653

Abstract

Pulmonary lavage immunoglobulins IgG, IgA and IgM were measured in intubated ventilated neonates during their period of intubation (range 1-64 days, mean 12). The neonates were divided into two groups based on gestational age (group 1 26-32 weeks, group 2 33-40 weeks). IgG levels were high at birth, and decreased exponentially throughout the period of intubation. There was no statistical difference in IgG levels between the two groups. IgA and IgM levels were low at birth, and increased linearly, there being a significantly greater increase with age in Group 2 (the more mature gestationally) for both immunoglobulins. Two groups of older children were also studied (2-4 year olds, and 8-10 year olds). In the 2-4 year age group, IgG levels were similar to those seen in the immediate newborn period, were quantitatively greater than IgA and IgM, and were not significantly different from levels in the 8-10 year olds. IgA and IgM levels were also not significantly different between the two groups.

Full text

PDF
357

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Andersson U. Development of B lymphocyte function in childhood. Acta Paediatr Scand. 1985 Jul;74(4):568–573. doi: 10.1111/j.1651-2227.1985.tb11031.x. [DOI] [PubMed] [Google Scholar]
  2. Ballow M., Cates K. L., Rowe J. C., Goetz C., Desbonnet C. Development of the immune system in very low birth weight (less than 1500 g) premature infants: concentrations of plasma immunoglobulins and patterns of infections. Pediatr Res. 1986 Sep;20(9):899–904. doi: 10.1203/00006450-198609000-00019. [DOI] [PubMed] [Google Scholar]
  3. Calhoun W. J., Christman J. W., Ershler W. B., Graham W. G., Davis G. S. Raised immunoglobulin concentrations in bronchoalveolar lavage fluid of healthy granite workers. Thorax. 1986 Apr;41(4):266–273. doi: 10.1136/thx.41.4.266. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Conway S. P., Dear P. R., Smith I. Immunoglobulin profile of the preterm baby. Arch Dis Child. 1985 Mar;60(3):208–212. doi: 10.1136/adc.60.3.208. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Conway S. P., Ng P. C., McLain B. Immunoglobulin prophylaxis for neonatal sepsis. Pediatr Infect Dis J. 1987 Jun;6(6):581–582. doi: 10.1097/00006454-198706000-00025. [DOI] [PubMed] [Google Scholar]
  6. Dubowitz L. M., Dubowitz V., Goldberg C. Clinical assessment of gestational age in the newborn infant. J Pediatr. 1970 Jul;77(1):1–10. doi: 10.1016/s0022-3476(70)80038-5. [DOI] [PubMed] [Google Scholar]
  7. Gleeson M., Cripps A. W., Clancy R. L., Husband A. J., Hensley M. J., Leeder S. R. Ontogeny of the secretory immune system in man. Aust N Z J Med. 1982 Aug;12(4):255–258. doi: 10.1111/j.1445-5994.1982.tb03806.x. [DOI] [PubMed] [Google Scholar]
  8. Glezen P., Denny F. W. Epidemiology of acute lower respiratory disease in children. N Engl J Med. 1973 Mar 8;288(10):498–505. doi: 10.1056/NEJM197303082881005. [DOI] [PubMed] [Google Scholar]
  9. Haque K. N., Zaidi M. H., Haque S. K., Bahakim H., el-Hazmi M., el-Swailam M. Intravenous immunoglobulin for prevention of sepsis in preterm and low birth weight infants. Pediatr Infect Dis. 1986 Nov-Dec;5(6):622–625. doi: 10.1097/00006454-198611000-00004. [DOI] [PubMed] [Google Scholar]
  10. Hobbs J. R., Davis J. A. Serum gamma-G-globulin levels and gestational age in premature babies. Lancet. 1967 Apr 8;1(7493):757–759. doi: 10.1016/s0140-6736(67)91369-4. [DOI] [PubMed] [Google Scholar]
  11. Ikegami M., Jacobs H., Jobe A. Surfactant function in respiratory distress syndrome. J Pediatr. 1983 Mar;102(3):443–447. doi: 10.1016/s0022-3476(83)80673-8. [DOI] [PubMed] [Google Scholar]
  12. Kaltreider H. B., Chan M. K. The class-specific immunoglobulin composition of fluids obtained from various levels of the canine respiratory tract. J Immunol. 1976 Feb;116(2):423–429. [PubMed] [Google Scholar]
  13. LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
  14. Lawrence E. C., Blaese R. M., Martin R. R., Stevens P. M. Immunoglobulin secreting cells in normal human bronchial lavage fluids. J Clin Invest. 1978 Oct;62(4):832–835. doi: 10.1172/JCI109195. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Loda F. A., Glezen W. P., Clyde W. A., Jr Respiratory disease in group day care. Pediatrics. 1972 Mar;49(3):428–437. [PubMed] [Google Scholar]
  16. Normand I. C., Reynolds E. O., Strang L. B. Passage of macromolecules between alveolar and interstitial spaces in foetal and newly ventilated lungs of the lamb. J Physiol. 1970 Sep;210(1):151–164. doi: 10.1113/jphysiol.1970.sp009201. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Quie P. G. Lung defense against infection. J Pediatr. 1986 May;108(5 Pt 2):813–816. doi: 10.1016/s0022-3476(86)80750-8. [DOI] [PubMed] [Google Scholar]
  18. Smart I. J., Koh L. Y. Competitive inhibition enzyme immunoassays for the measurement of human IgG, IgA and IgM. J Immunol Methods. 1983 Jun 10;60(3):329–339. doi: 10.1016/0022-1759(83)90290-9. [DOI] [PubMed] [Google Scholar]
  19. Stephens S. Development of secretory immunity in breast fed and bottle fed infants. Arch Dis Child. 1986 Mar;61(3):263–269. doi: 10.1136/adc.61.3.263. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Takemura T., Eishi Y. Distribution of secretory component and immunoglobulins in the developing lung. Am Rev Respir Dis. 1985 Jan;131(1):125–130. doi: 10.1164/arrd.1985.131.1.125. [DOI] [PubMed] [Google Scholar]
  21. Waldman R. H., Jurgensen P. F., Olsen G. N., Ganguly R., Johnson J. E., 3rd Immune response of the human respiratory tract. I. Immunoglobulin levels and influenza virus vaccine antibody response. J Immunol. 1973 Jul;111(1):38–41. [PubMed] [Google Scholar]

Articles from Clinical and Experimental Immunology are provided here courtesy of British Society for Immunology

RESOURCES