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. 1988 Jul;73(1):11–16.

Natural killing of fibroblasts infected with low-passage clinical isolates of human cytomegalovirus.

S Bandyopadhyay 1, S H Oh 1, S Michelson 1, D S Miller 1, J L Virelizier 1, S E Starr 1
PMCID: PMC1541462  PMID: 2844455

Abstract

Fibroblasts infected with most low-passage clinical isolates of human cytomegalovirus (CMV) were as susceptible to lysis by human natural killer (NK) cells as high passage AD-169-infected fibroblasts. NK lysis occurred despite the absence of detectable CMV-specific late membrane antigen(s) on the majority of the target cells infected with most of the low passage strains. The magnitude of NK lysis of different CMV-infected target cells did not correlate with their ability to induce IFN-alpha. NK cell-mediated lysis of cells infected with low-passage clinical isolates of CMV required both NK cells and HLA-DR+ accessory cells, as previously shown for AD-169-infected target cells.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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