Skip to main content
NCBI home page
Clinical and Experimental Immunology logoLink to Clinical and Experimental Immunology
. 1988 Apr;72(1):1–8.

Mechanisms of autoimmunity in insulin-dependent diabetes mellitus.

J F Bach 1
PMCID: PMC1541485  PMID: 3293847

Full text

PDF
1

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Adams T. E., Alpert S., Hanahan D. Non-tolerance and autoantibodies to a transgenic self antigen expressed in pancreatic beta cells. Nature. 1987 Jan 15;325(6101):223–228. doi: 10.1038/325223a0. [DOI] [PubMed] [Google Scholar]
  2. Altmann D. M., Lider O., Douek D. C., Cohen I. R. Activation of specific T cell lines by the antigens avidin and myelin basic protein in the absence of antigen-presenting cells. Eur J Immunol. 1987 Nov;17(11):1635–1640. doi: 10.1002/eji.1830171117. [DOI] [PubMed] [Google Scholar]
  3. Assan R., Feutren G., Debray-Sachs M., Quiniou-Debrie M. C., Laborie C., Thomas G., Chatenoud L., Bach J. F. Metabolic and immunological effects of cyclosporin in recently diagnosed type 1 diabetes mellitus. Lancet. 1985 Jan 12;1(8420):67–71. doi: 10.1016/s0140-6736(85)91964-6. [DOI] [PubMed] [Google Scholar]
  4. Bach J. F., Boitard C. Experimental models of type-I diabetes. Pathol Immunopathol Res. 1986;5(3-5):384–415. doi: 10.1159/000157028. [DOI] [PubMed] [Google Scholar]
  5. Baekkeskov S., Landin M., Kristensen J. K., Srikanta S., Bruining G. J., Mandrup-Poulsen T., de Beaufort C., Soeldner J. S., Eisenbarth G., Lindgren F. Antibodies to a 64,000 Mr human islet cell antigen precede the clinical onset of insulin-dependent diabetes. J Clin Invest. 1987 Mar;79(3):926–934. doi: 10.1172/JCI112903. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Baekkeskov S., Nielsen J. H., Marner B., Bilde T., Ludvigsson J., Lernmark A. Autoantibodies in newly diagnosed diabetic children immunoprecipitate human pancreatic islet cell proteins. Nature. 1982 Jul 8;298(5870):167–169. doi: 10.1038/298167a0. [DOI] [PubMed] [Google Scholar]
  7. Bell G. I., Horita S., Karam J. H. A polymorphic locus near the human insulin gene is associated with insulin-dependent diabetes mellitus. Diabetes. 1984 Feb;33(2):176–183. doi: 10.2337/diab.33.2.176. [DOI] [PubMed] [Google Scholar]
  8. Bendelac A., Carnaud C., Boitard C., Bach J. F. Syngeneic transfer of autoimmune diabetes from diabetic NOD mice to healthy neonates. Requirement for both L3T4+ and Lyt-2+ T cells. J Exp Med. 1987 Oct 1;166(4):823–832. doi: 10.1084/jem.166.4.823. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Bendtzen K., Mandrup-Poulsen T., Nerup J., Nielsen J. H., Dinarello C. A., Svenson M. Cytotoxicity of human pI 7 interleukin-1 for pancreatic islets of Langerhans. Science. 1986 Jun 20;232(4757):1545–1547. doi: 10.1126/science.3086977. [DOI] [PubMed] [Google Scholar]
  10. Bogardus C., Taskinen M. R., Zawadzki J., Lillioja S., Mott D., Howard B. V. Increased resting metabolic rates in obese subjects with non-insulin-dependent diabetes mellitus and the effect of sulfonylurea therapy. Diabetes. 1986 Jan;35(1):1–5. doi: 10.2337/diab.35.1.1. [DOI] [PubMed] [Google Scholar]
  11. Boitard C., Chatenoud L. M., Debray-Sachs M. In vitro inhibition of pancreatic B cell function by lymphocytes from diabetics with associated autoimmune diseases: a T cell phenomenon. J Immunol. 1982 Dec;129(6):2529–2531. [PubMed] [Google Scholar]
  12. Boitard C., Debray-Sachs M., Pouplard A., Assan R., Hamburger J. Lymphocytes from diabetics suppress insulin release in vitro. Diabetologia. 1981 Jul;21(1):41–46. doi: 10.1007/BF03216222. [DOI] [PubMed] [Google Scholar]
  13. Boitard C., Michie S., Serrurier P., Butcher G. W., Larkins A. P., McDevitt H. O. In vivo prevention of thyroid and pancreatic autoimmunity in the BB rat by antibody to class II major histocompatibility complex gene products. Proc Natl Acad Sci U S A. 1985 Oct;82(19):6627–6631. doi: 10.1073/pnas.82.19.6627. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Bottazzo G. F., Dean B. M., McNally J. M., MacKay E. H., Swift P. G., Gamble D. R. In situ characterization of autoimmune phenomena and expression of HLA molecules in the pancreas in diabetic insulitis. N Engl J Med. 1985 Aug 8;313(6):353–360. doi: 10.1056/NEJM198508083130604. [DOI] [PubMed] [Google Scholar]
  15. Bottazzo G. F., Florin-Christensen A., Doniach D. Islet-cell antibodies in diabetes mellitus with autoimmune polyendocrine deficiencies. Lancet. 1974 Nov 30;2(7892):1279–1283. doi: 10.1016/s0140-6736(74)90140-8. [DOI] [PubMed] [Google Scholar]
  16. Bottazzo G. F., Pujol-Borrell R., Hanafusa T., Feldmann M. Role of aberrant HLA-DR expression and antigen presentation in induction of endocrine autoimmunity. Lancet. 1983 Nov 12;2(8359):1115–1119. doi: 10.1016/s0140-6736(83)90629-3. [DOI] [PubMed] [Google Scholar]
  17. Buse J. B., Rifai-Haddad R., Lees S., Taniguchi H., Chaplin D., Milford E. M., Seidman J. G., Eisenbarth G. S., Jackson R. A. Major histocompatibility complex restriction fragment length polymorphisms define three diabetogenic haplotypes in BB and BBN rats. J Exp Med. 1985 Aug 1;162(2):444–458. doi: 10.1084/jem.162.2.444. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Cohen D., Cohen O., Marcadet A., Massart C., Lathrop M., Deschamps I., Hors J., Schuller E., Dausset J. Class II HLA-DC beta-chain DNA restriction fragments differentiate among HLA-DR2 individuals in insulin-dependent diabetes and multiple sclerosis. Proc Natl Acad Sci U S A. 1984 Mar;81(6):1774–1778. doi: 10.1073/pnas.81.6.1774. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Colle E., Guttmann R. D., Seemayer T. Spontaneous diabetes mellitus syndrome in the rat. I. Association with the major histocompatibility complex. J Exp Med. 1981 Oct 1;154(4):1237–1242. doi: 10.1084/jem.154.4.1237. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Dean B. M., Walker R., Bone A. J., Baird J. D., Cooke A. Pre-diabetes in the spontaneously diabetic BB/E rat: lymphocyte subpopulations in the pancreatic infiltrate and expression of rat MHC class II molecules in endocrine cells. Diabetologia. 1985 Jul;28(7):464–466. doi: 10.1007/BF00280892. [DOI] [PubMed] [Google Scholar]
  21. Greiner D. L., Mordes J. P., Handler E. S., Angelillo M., Nakamura N., Rossini A. A. Depletion of RT6.1+ T lymphocytes induces diabetes in resistant biobreeding/Worcester (BB/W) rats. J Exp Med. 1987 Aug 1;166(2):461–475. doi: 10.1084/jem.166.2.461. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Gupta S., Fikrig S. M., Khanna S., Orti E. Deficiency of suppressor T-cells in insulin-dependent diabetes mellitus: an analysis with monoclonal antibodies. Immunol Lett. 1982 May;4(5):289–294. doi: 10.1016/0165-2478(82)90054-2. [DOI] [PubMed] [Google Scholar]
  23. Harada M., Makino S. Promotion of spontaneous diabetes in non-obese diabetes-prone mice by cyclophosphamide. Diabetologia. 1984 Dec;27(6):604–606. doi: 10.1007/BF00276978. [DOI] [PubMed] [Google Scholar]
  24. Hattori M., Buse J. B., Jackson R. A., Glimcher L., Dorf M. E., Minami M., Makino S., Moriwaki K., Kuzuya H., Imura H. The NOD mouse: recessive diabetogenic gene in the major histocompatibility complex. Science. 1986 Feb 14;231(4739):733–735. doi: 10.1126/science.3003909. [DOI] [PubMed] [Google Scholar]
  25. Haynes B. F., Hemler M. E., Mann D. L., Eisenbarth G. S., Shelhamer J., Mostowski H. S., Thomas C. A., Strominger J. L., Fauci A. S. Characterization of a monoclonal antibody (4F2) that binds to human monocytes and to a subset of activated lymphocytes. J Immunol. 1981 Apr;126(4):1409–1414. [PubMed] [Google Scholar]
  26. Jackson R. A., Morris M. A., Haynes B. F., Eisenbarth G. S. Increased circulating Ia-antigen-bearing T cells in type I diabetes mellitus. N Engl J Med. 1982 Apr 1;306(13):785–788. doi: 10.1056/NEJM198204013061305. [DOI] [PubMed] [Google Scholar]
  27. Kaye W. A., Adri M. N., Soeldner J. S., Rabinowe S. L., Kaldany A., Kahn C. R., Bistrian B., Srikanta S., Ganda O. P., Eisenbarth G. S. Acquired defect in interleukin-2 production in patients with type I diabetes mellitus. N Engl J Med. 1986 Oct 9;315(15):920–924. doi: 10.1056/NEJM198610093151502. [DOI] [PubMed] [Google Scholar]
  28. Koevary S., Rossini A., Stoller W., Chick W., Williams R. M. Passive transfer of diabetes in the BB/W rat. Science. 1983 May 13;220(4598):727–728. doi: 10.1126/science.6836309. [DOI] [PubMed] [Google Scholar]
  29. Koike T., Itoh Y., Ishii T., Ito I., Takabayashi K., Maruyama N., Tomioka H., Yoshida S. Preventive effect of monoclonal anti-L3T4 antibody on development of diabetes in NOD mice. Diabetes. 1987 Apr;36(4):539–541. doi: 10.2337/diab.36.4.539. [DOI] [PubMed] [Google Scholar]
  30. Laborie C., Sai P., Feutren G., Debray-Sachs M., Quiniou-Debrie M. C., Poussier P., Marliss E. B., Assan R. Time course of islet cell antibodies in diabetic and nondiabetic BB rats. Diabetes. 1985 Sep;34(9):904–910. doi: 10.2337/diab.34.9.904. [DOI] [PubMed] [Google Scholar]
  31. Like A. A., Kislauskis E., Williams R. R., Rossini A. A. Neonatal thymectomy prevents spontaneous diabetes mellitus in the BB/W rat. Science. 1982 May 7;216(4546):644–646. doi: 10.1126/science.7041259. [DOI] [PubMed] [Google Scholar]
  32. Like A. A., Rossini A. A., Guberski D. L., Appel M. C., Williams R. M. Spontaneous diabetes mellitus: reversal and prevention in the BB/W rat with antiserum to rat lymphocytes. Science. 1979 Dec 21;206(4425):1421–1423. doi: 10.1126/science.388619. [DOI] [PubMed] [Google Scholar]
  33. Like A. A., Rossini A. A. Streptozotocin-induced pancreatic insulitis: new model of diabetes mellitus. Science. 1976 Jul 30;193(4251):415–417. doi: 10.1126/science.180605. [DOI] [PubMed] [Google Scholar]
  34. Like A. A., Weringer E. J., Holdash A., McGill P., Atkinson D., Rossini A. A. Adoptive transfer of autoimmune diabetes mellitus in biobreeding/Worcester (BB/W) inbred and hybrid rats. J Immunol. 1985 Mar;134(3):1583–1587. [PubMed] [Google Scholar]
  35. Makino S., Kunimoto K., Muraoka Y., Mizushima Y., Katagiri K., Tochino Y. Breeding of a non-obese, diabetic strain of mice. Jikken Dobutsu. 1980 Jan;29(1):1–13. doi: 10.1538/expanim1978.29.1_1. [DOI] [PubMed] [Google Scholar]
  36. Mascart-Lemone F., Delespesse G., Dorchy H., Lemiere B., Servais G. Characterization of immunoregulatory T lymphocytes in insulin-dependent diabetic children by means of monoclonal antibodies. Clin Exp Immunol. 1982 Feb;47(2):296–300. [PMC free article] [PubMed] [Google Scholar]
  37. Mordes J. P., Gallina D. L., Handler E. S., Greiner D. L., Nakamura N., Pelletier A., Rossini A. A. Transfusions enriched for W3/25+ helper/inducer T lymphocytes prevent spontaneous diabetes in the BB/W rat. Diabetologia. 1987 Jan;30(1):22–26. doi: 10.1007/BF01788902. [DOI] [PubMed] [Google Scholar]
  38. Mori Y., Suko M., Okudaira H., Matsuba I., Tsuruoka A., Sasaki A., Yokoyama H., Tanase T., Shida T., Nishimura M. Preventive effects of cyclosporin on diabetes in NOD mice. Diabetologia. 1986 Apr;29(4):244–247. doi: 10.1007/BF00454884. [DOI] [PubMed] [Google Scholar]
  39. Nayak R. C., Omar M. A., Rabizadeh A., Srikanta S., Eisenbarth G. S. "Cytoplasmic" islet cell antibodies. Evidence that the target antigen is a sialoglycoconjugate. Diabetes. 1985 Jun;34(6):617–619. doi: 10.2337/diab.34.6.617. [DOI] [PubMed] [Google Scholar]
  40. Nishimoto H., Kikutani H., Yamamura K., Kishimoto T. Prevention of autoimmune insulitis by expression of I-E molecules in NOD mice. 1987 Jul 30-Aug 5Nature. 328(6129):432–434. doi: 10.1038/328432a0. [DOI] [PubMed] [Google Scholar]
  41. Orlow S., Yasunami R., Boitard C., Bach J. F. Induction précoce du diabète chez la souris NOD par la streptozotocine. C R Acad Sci III. 1987;304(3):77–78. [PubMed] [Google Scholar]
  42. Palmer J. P., Asplin C. M., Clemons P., Lyen K., Tatpati O., Raghu P. K., Paquette T. L. Insulin antibodies in insulin-dependent diabetics before insulin treatment. Science. 1983 Dec 23;222(4630):1337–1339. doi: 10.1126/science.6362005. [DOI] [PubMed] [Google Scholar]
  43. Prochazka M., Leiter E. H., Serreze D. V., Coleman D. L. Three recessive loci required for insulin-dependent diabetes in nonobese diabetic mice. Science. 1987 Jul 17;237(4812):286–289. doi: 10.1126/science.2885918. [DOI] [PubMed] [Google Scholar]
  44. Quiniou-Debrie M. C., Debray-Sachs M., Dardenne M., Czernichow P., Assan R., Bach J. F. Anti-islet cellular and humoral immunity, T-cell subsets, and thymic function in type I diabetes. Diabetes. 1985 Apr;34(4):373–379. doi: 10.2337/diab.34.4.373. [DOI] [PubMed] [Google Scholar]
  45. Rossini A. A., Faustman D., Woda B. A., Like A. A., Szymanski I., Mordes J. P. Lymphocyte transfusions prevent diabetes in the Bio-Breeding/Worcester rat. J Clin Invest. 1984 Jul;74(1):39–46. doi: 10.1172/JCI111416. [DOI] [PMC free article] [PubMed] [Google Scholar]
  46. Rossini A. A., Mordes J. P., Like A. A. Immunology of insulin-dependent diabetes mellitus. Annu Rev Immunol. 1985;3:289–320. doi: 10.1146/annurev.iy.03.040185.001445. [DOI] [PubMed] [Google Scholar]
  47. Sai P., Boitard C., Debray-Sachs M., Pouplard A., Assan R., Hamburger J. Complement-fixing Islet cell antibodies from some diabetic patients alter insulin release in vitro. Diabetes. 1981 Dec;30(12):1051–1057. doi: 10.2337/diab.30.12.1051. [DOI] [PubMed] [Google Scholar]
  48. Sibley R. K., Sutherland D. E., Goetz F., Michael A. F. Recurrent diabetes mellitus in the pancreas iso- and allograft. A light and electron microscopic and immunohistochemical analysis of four cases. Lab Invest. 1985 Aug;53(2):132–144. [PubMed] [Google Scholar]
  49. Spies T., Morton C. C., Nedospasov S. A., Fiers W., Pious D., Strominger J. L. Genes for the tumor necrosis factors alpha and beta are linked to the human major histocompatibility complex. Proc Natl Acad Sci U S A. 1986 Nov;83(22):8699–8702. doi: 10.1073/pnas.83.22.8699. [DOI] [PMC free article] [PubMed] [Google Scholar]
  50. Srikanta S., Ganda O. P., Eisenbarth G. S., Soeldner J. S. Islet-cell antibodies and beta-cell function in monozygotic triplets and twins initially discordant for Type I diabetes mellitus. N Engl J Med. 1983 Feb 10;308(6):322–325. doi: 10.1056/NEJM198302103080607. [DOI] [PubMed] [Google Scholar]
  51. Stiller C. R., Dupré J., Gent M., Jenner M. R., Keown P. A., Laupacis A., Martell R., Rodger N. W., von Graffenried B., Wolfe B. M. Effects of cyclosporine immunosuppression in insulin-dependent diabetes mellitus of recent onset. Science. 1984 Mar 30;223(4643):1362–1367. doi: 10.1126/science.6367043. [DOI] [PubMed] [Google Scholar]
  52. Todd J. A., Bell J. I., McDevitt H. O. HLA-DQ beta gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus. Nature. 1987 Oct 15;329(6140):599–604. doi: 10.1038/329599a0. [DOI] [PubMed] [Google Scholar]
  53. Uchigata Y., Spitalnik S. L., Tachiwaki O., Salata K. F., Notkins A. L. Pancreatic islet cell surface glycoproteins containing Gal beta 1-4GlcNAc-R identified by a cytotoxic monoclonal autoantibody. J Exp Med. 1987 Jan 1;165(1):124–139. doi: 10.1084/jem.165.1.124. [DOI] [PMC free article] [PubMed] [Google Scholar]
  54. Weringer E. J., Like A. A. Immune attack on pancreatic islet transplants in the spontaneously diabetic BioBreeding/Worcester (BB/W) rat is not MHC restricted. J Immunol. 1985 Apr;134(4):2383–2386. [PubMed] [Google Scholar]
  55. Wicker L. S., Miller B. J., Coker L. Z., McNally S. E., Scott S., Mullen Y., Appel M. C. Genetic control of diabetes and insulitis in the nonobese diabetic (NOD) mouse. J Exp Med. 1987 Jun 1;165(6):1639–1654. doi: 10.1084/jem.165.6.1639. [DOI] [PMC free article] [PubMed] [Google Scholar]
  56. Wicker L. S., Miller B. J., Mullen Y. Transfer of autoimmune diabetes mellitus with splenocytes from nonobese diabetic (NOD) mice. Diabetes. 1986 Aug;35(8):855–860. doi: 10.2337/diab.35.8.855. [DOI] [PubMed] [Google Scholar]

Articles from Clinical and Experimental Immunology are provided here courtesy of British Society for Immunology

RESOURCES