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. 1988 Apr;72(1):37–42.

Interaction between fibronectin and C1q in rheumatoid synovial fluid and normal plasma.

S E Carsons 1, S Schwartzman 1, H S Diamond 1, E Berkowitz 1
PMCID: PMC1541486  PMID: 3135129

Abstract

The interaction between fibronectin and C1q was studied in the presence of normal human plasma and rheumatoid synovial fluid by solid phase binding assay. Fibronectin-C1q binding occurred in the presence of rheumatoid synovial fluid but not in the presence of normal plasma. Binding was strongest at 4 degrees C and in the presence of EDTA. Fibronectin-C1q binding could be induced in the presence of normal plasma by hypotonicity, augmentation of the concentration of solution-phase fibronectin or by the addition of heat-aggregated IgG. The C1q present in rheumatoid synovial fluid bound to both aminoterminal collagen-binding and carboxyterminal noncollagen binding fibronectin fragments although binding to the aminoterminal fragment was stronger. The interaction between fibronectin and C1q in rheumatoid synovial fluid may modulate immune-complex deposition and complement activation in the inflamed joint.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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