Skip to main content
PMC home page
Clinical and Experimental Immunology logoLink to Clinical and Experimental Immunology
. 1988 May;72(2):249–254.

Interleukin 2 receptor in patients with localized and systemic parasitic diseases.

O Josimovic-Alasevic 1, H Feldmeier 1, K Zwingenberger 1, G Harms 1, H Hahn 1, M Shrisuphanunt 1, T Diamantstein 1
PMCID: PMC1541536  PMID: 3136958

Abstract

An enzyme-linked immunosorbent assay was used to quantify soluble interleukin 2 receptor (IL-2R) in the serum of patients with helminthic and protozoal infections. The results demonstrated that levels of IL-2R were normal in patients with helminthic infections limited to the intestinal tract (ascariasis, trichuriasis), but significantly elevated in patients with systemic or long-lasting infections (strongyloidiasis, schistosomiasis, fascioliasis, opisthorchiasis). In patients infected with Schistosoma mansoni levels of IL-2R were higher in those with the hepatosplenic than in those with the intestinal form of the disease. Patients with malaria also showed increased serum levels of IL-2R, irrespective whether the infection was caused by Plasmodium falciparum or P. vivax. No difference was observed between patients with acute or history of malaria. The highest levels of IL-2R were observed in patients with visceral leishmaniasis. Interestingly, in these patients the concentration of IL-2R correlated to specific antibody titre. The results are discussed in the context of preferential activation of T lymphocytes, B lymphocytes and/or macrophages during the course of the different parasitic infections investigated.

Full text

PDF
249

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BLAGG W., SCHLOEGEL E. L., MANSOUR N. S., KHALAF G. I. A new concentration technic for the demonstration of protozoa and helminth eggs in feces. Am J Trop Med Hyg. 1955 Jan;4(1):23–28. doi: 10.4269/ajtmh.1955.4.23. [DOI] [PubMed] [Google Scholar]
  2. Balderas R. S., Josimovic-Alasevic O., Diamantstein T., Dixon F. J., Theofilopoulos A. N. Elevated titers of cell-free interleukin 2 receptor in serum of lupus mice. J Immunol. 1987 Sep 1;139(5):1496–1500. [PubMed] [Google Scholar]
  3. Barral A., Carvalho E. M., Badaró R., Barral-Netto M. Suppression of lymphocyte proliferative responses by sera from patients with American visceral leishmaniasis. Am J Trop Med Hyg. 1986 Jul;35(4):735–742. doi: 10.4269/ajtmh.1986.35.735. [DOI] [PubMed] [Google Scholar]
  4. Colley D. G., Garcia A. A., Lambertucci J. R., Parra J. C., Katz N., Rocha R. S., Gazzinelli G. Immune responses during human schistosomiasis. XII. Differential responsiveness in patients with hepatosplenic disease. Am J Trop Med Hyg. 1986 Jul;35(4):793–802. [PubMed] [Google Scholar]
  5. Colvin R. B., Fuller T. C., MacKeen L., Kung P. C., Ip S. H., Cosimi A. B. Plasma interleukin 2 receptor levels in renal allograft recipients. Clin Immunol Immunopathol. 1987 May;43(2):273–276. doi: 10.1016/0090-1229(87)90135-8. [DOI] [PubMed] [Google Scholar]
  6. Cresswell P., Springer T., Strominger J. L., Turner M. J., Grey H. M., Kubo R. T. Immunological identity of the small subunit of HL-A antigens and beta2-microglobulin and its turnover on the cell membrane. Proc Natl Acad Sci U S A. 1974 May;71(5):2123–2127. doi: 10.1073/pnas.71.5.2123. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Diamantstein T., Klos M., Gold D., Hahn H. Interaction between Entamoeba histolytica and the immune system. I. Mitogenicity of Entamoeba histolytica extracts for human peripheral T lymphocytes. J Immunol. 1981 Jun;126(6):2084–2086. [PubMed] [Google Scholar]
  8. Diamantstein T., Osawa H., Mouzaki A., Josimovic-Alasevic O. Regulation of interleukin-2 receptor expression and receptor release. Mol Immunol. 1986 Nov;23(11):1165–1172. doi: 10.1016/0161-5890(86)90147-1. [DOI] [PubMed] [Google Scholar]
  9. Diamantstein T. The interleukin 2 receptor and its physiology. Implications for combatting autoimmune diseases and transplant rejections. Behring Inst Mitt. 1987 Jun;(81):73–87. [PubMed] [Google Scholar]
  10. Doughty B. L., Zodda D. M., el Kholy A., Phillips S. M. Delayed type hypersensitivity granuloma formation around Schistosoma mansoni eggs in vitro. IV. Granuloma formation in human schistosomiasis. Am J Trop Med Hyg. 1984 Nov;33(6):1173–1177. doi: 10.4269/ajtmh.1984.33.1173. [DOI] [PubMed] [Google Scholar]
  11. Ey P. L., Prowse S. J., Jenkin C. R. Isolation of pure IgG1, IgG2a and IgG2b immunoglobulins from mouse serum using protein A-sepharose. Immunochemistry. 1978 Jul;15(7):429–436. doi: 10.1016/0161-5890(78)90070-6. [DOI] [PubMed] [Google Scholar]
  12. Feldmeier H., Gastl G. A., Poggensee U., Kortmann C., Daffalla A. A., Peter H. H. Relationship between intensity of infection and immunomodulation in human schistosomiasis. I. Lymphocyte subpopulations and specific antibody responses. Clin Exp Immunol. 1985 May;60(2):225–233. [PMC free article] [PubMed] [Google Scholar]
  13. Feldmeier H., Gastl G. A., Poggensee U., Kortmann C., Daffalla A. A., Peter H. H. Relationship between intensity of infection and immunomodulation in human schistosomiasis. II. NK cell activity and in vitro lymphocyte proliferation. Clin Exp Immunol. 1985 May;60(2):234–240. [PMC free article] [PubMed] [Google Scholar]
  14. Garcia A. A., da Silva A. L., de Oliveira L. R., Katz N., Gazzinelli G., Colley D. G. Immune responses during human schistosomiasis mansoni. XIII. Immunological status of spleen cells from hospital patients with hepatosplenic disease. Scand J Immunol. 1986 Oct;24(4):413–420. doi: 10.1111/j.1365-3083.1986.tb02129.x. [DOI] [PubMed] [Google Scholar]
  15. Gastl G. A., Feldmeier H., Doehring E., Kortmann C., Daffalla A. A., Peter H. H. Numerical and functional alterations of lymphocytes in human schistosomiasis. Scand J Immunol. 1984 May;19(5):469–479. doi: 10.1111/j.1365-3083.1984.tb00956.x. [DOI] [PubMed] [Google Scholar]
  16. Genta R. M., Ottesen E. A., Neva F. A., Walzer P. D., Tanowitz H. B., Wittner M. Cellular responses in human strongyloidiasis. Am J Trop Med Hyg. 1983 Sep;32(5):990–994. doi: 10.4269/ajtmh.1983.32.990. [DOI] [PubMed] [Google Scholar]
  17. Herrmann F., Cannistra S. A., Levine H., Griffin J. D. Expression of interleukin 2 receptors and binding of interleukin 2 by gamma interferon-induced human leukemic and normal monocytic cells. J Exp Med. 1985 Sep 1;162(3):1111–1116. doi: 10.1084/jem.162.3.1111. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Katz M. E., Tite J. P., Janeway C. A., Jr The immunobiology of T cell responses to Mls-locus-disparate stimulator cells. III. Helper and cytolytic functions of cloned, Mls-reactive T cell lines. J Immunol. 1986 Jan;136(1):1–5. [PubMed] [Google Scholar]
  19. Mouzaki A., Osawa H., Diamantstein T. An ELISA that detects cell-associated and released rat IL-2 receptors in a soluble form. J Immunol Methods. 1987 Jun 26;100(1-2):243–248. doi: 10.1016/0022-1759(87)90195-5. [DOI] [PubMed] [Google Scholar]
  20. Neogy A. B., Nandy A., Dastidar B. G., Chowdhury A. B. B lymphocyte population and immunoglobulins in Indian kala-azar in response to chemotherapy. Acta Trop. 1986 Sep;43(3):237–244. [PubMed] [Google Scholar]
  21. Osawa H., Josimovic-Alasevic O., Diamantstein T. Enzyme-linked immunosorbent assay of mouse interleukin-2 receptors. J Immunol Methods. 1986 Aug 21;92(1):109–115. doi: 10.1016/0022-1759(86)90510-7. [DOI] [PubMed] [Google Scholar]
  22. Piessens W. F., Ratiwayanto S., Tuti S., Palmieri J. H., Piessens P. W., Koiman I., Dennis D. T. Antigen-specific suppressor cells and suppressor factors in human filariasis with Brugia malayi. N Engl J Med. 1980 Apr 10;302(15):833–837. doi: 10.1056/NEJM198004103021503. [DOI] [PubMed] [Google Scholar]
  23. Pizzolo G., Chilosi M., Vinante F., Dazzi F., Lestani M., Perona G., Benedetti F., Todeschini G., Vincenzi C., Trentin L. Soluble interleukin-2 receptors in the serum of patients with Hodgkin's disease. Br J Cancer. 1987 Apr;55(4):427–428. doi: 10.1038/bjc.1987.83. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Reske-Kunz A. B., Osawa H., Josimović-Alasević O., Rüde E., Diamantstein T. Soluble interleukin 2 receptors are released by long term-cultured insulin-specific T cells transiently after contact with antigen. J Immunol. 1987 Jan 1;138(1):192–196. [PubMed] [Google Scholar]
  25. Rubin L. A., Kurman C. C., Fritz M. E., Biddison W. E., Boutin B., Yarchoan R., Nelson D. L. Soluble interleukin 2 receptors are released from activated human lymphoid cells in vitro. J Immunol. 1985 Nov;135(5):3172–3177. [PubMed] [Google Scholar]
  26. Schirrmacher V., Josimovic-Alasevic O., Osawa H., Diamantstein T. Determination of cell-free interleukin 2 receptor level in the serum of normal animals and of animals bearing IL-2 receptor positive tumours with high or low metastatic capacity. Br J Cancer. 1987 Jun;55(6):583–587. doi: 10.1038/bjc.1987.119. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Strickland G. T. Lymphocyte mitogenic factor in sera from patients with falciparum malaria. Tropenmed Parasitol. 1978 Jun;29(2):198–203. [PubMed] [Google Scholar]
  28. Todd C. W., Goodgame R. W., Colley D. G. Immune responses during human schistosomiasis mansoni. VII. Further analysis of the interactions between patient sera and lymphocytes during in vitro blastogenesis to schistosome antigen preparations. Am J Trop Med Hyg. 1980 Sep;29(5):875–881. [PubMed] [Google Scholar]
  29. Tung K. S., Umland E., Matzner P., Nelson K., Schauf V., Rubin L., Wagner D., Scollard D., Vithayasai P., Vithayasai V. Soluble serum interleukin 2 receptor levels in leprosy patients. Clin Exp Immunol. 1987 Jul;69(1):10–15. [PMC free article] [PubMed] [Google Scholar]
  30. Volk H. D., Brocke S., Osawa H., Diamantstein T. Suppression of the local graft-vs.-host reaction in rats by treatment with a monoclonal antibody specific for the interleukin 2 receptor. Eur J Immunol. 1986 Oct;16(10):1309–1312. doi: 10.1002/eji.1830161020. [DOI] [PubMed] [Google Scholar]

Articles from Clinical and Experimental Immunology are provided here courtesy of British Society for Immunology

RESOURCES