Skip to main content
NCBI home page
Clinical and Experimental Immunology logoLink to Clinical and Experimental Immunology
. 1988 Mar;71(3):433–438.

Decrease of IgE-dependent platelet activation in Hymenoptera hypersensitivity after specific rush desensitization.

A Tsicopoulos 1, A B Tonnel 1, B Wallaert 1, M Joseph 1, J C Ameisen 1, P Ramon 1, J P Dessaint 1, A Capron 1
PMCID: PMC1541673  PMID: 3383448

Abstract

A receptor for the Fc fragment of IgE on human platelets has been recently described, which mediated an IgE-dependent activation in the presence of specific allergen. We investigated the allergen-induced activation of platelets from patients with Hymenoptera hypersensitivity before and after specific rush desensitization. Nineteen patients with a history of anaphylactic reactions were included (15 sensitive to yellow-jacket and four to honey-bee venom), fourteen/nineteen having experienced severe life-threatening systemic reactions and 5/19 large local reactions. All showed positive skin tests and high values of specific IgE. By comparison to the baseline results obtained before desensitization, a significant decrease of platelet activation (76.8% inhibition) after rush desensitization was observed. In the case of two polysensitized patients, after Hymenoptera venom desensitization alone, platelets not only lost their reactivity to venom but also towards the other allergen. This modulation of the IgE-dependent platelet reactivity during desensitization offers therefore a new approach for the study of allergen-induced desensitization.

Full text

PDF
433

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ameisen J. C., Capron A., Joseph M., Maclouf J., Vorng H., Pancré V., Fournier E., Wallaert B., Tonnel A. B. Aspirin-sensitive asthma: abnormal platelet response to drugs inducing asthmatic attacks. Diagnostic and physiopathological implications. Int Arch Allergy Appl Immunol. 1985;78(4):438–448. doi: 10.1159/000233927. [DOI] [PubMed] [Google Scholar]
  2. Caen J. P., Nurden A. T., Jeanneau C., Michel H., Tobelem G., Levy-Toledano S., Sultan Y., Valensi F., Bernard J. Bernard-Soulier syndrome: a new platelet glycoprotein abnormality. Its relationship with platelet adhesion to subendothelium and with the factor VIII von Willebrand protein. J Lab Clin Med. 1976 Apr;87(4):586–596. [PubMed] [Google Scholar]
  3. Capron A., Dessaint J. P., Capron M., Bazin H. Specific IgE antibodies in immune adherence of normal macrophages to Schistosoma mansoni schistosomules. Nature. 1975 Feb 6;253(5491):474–475. doi: 10.1038/253474a0. [DOI] [PubMed] [Google Scholar]
  4. Capron M., Capron A., Dessaint J. P., Torpier G., Johansson S. G., Prin L. Fc receptors for IgE on human and rat eosinophils. J Immunol. 1981 Jun;126(6):2087–2092. [PubMed] [Google Scholar]
  5. Capron M., Kusnierz J. P., Prin L., Spiegelberg H. L., Ovlaque G., Gosset P., Tonnel A. B., Capron A. Cytophilic IgE on human blood and tissue eosinophils: detection by flow microfluorometry. J Immunol. 1985 May;134(5):3013–3018. [PubMed] [Google Scholar]
  6. Cines D. B., van der Keyl H., Levinson A. I. In vitro binding of an IgE protein to human platelets. J Immunol. 1986 May 1;136(9):3433–3440. [PubMed] [Google Scholar]
  7. Clausen R. W., Yanari S. S. Immune complex-mediated disease not a factor in patients on maintenance venom immunotherapy. J Allergy Clin Immunol. 1983 Aug;72(2):199–203. doi: 10.1016/0091-6749(83)90530-4. [DOI] [PubMed] [Google Scholar]
  8. Gatien J. G., Merler E., Colten H. R. Allergy to ragweed antigen E: effect of specific immunotherapy on the reactivity of human T lymphocytes in vitro. Clin Immunol Immunopathol. 1975 May;4(1):32–37. doi: 10.1016/0090-1229(75)90036-7. [DOI] [PubMed] [Google Scholar]
  9. Hsieh K. H. Changes of lymphoproliferative responses of T cell subsets to allergen and mitogen after hyposensitization in asthmatic children. J Allergy Clin Immunol. 1984 Jul;74(1):34–40. doi: 10.1016/0091-6749(84)90084-8. [DOI] [PubMed] [Google Scholar]
  10. Hunt K. J., Valentine M. D., Sobotka A. K., Benton A. W., Amodio F. J., Lichtenstein L. M. A controlled trial of immunotherapy in insect hypersensitivity. N Engl J Med. 1978 Jul 27;299(4):157–161. doi: 10.1056/NEJM197807272990401. [DOI] [PubMed] [Google Scholar]
  11. Joseph M., Capron A., Ameisen J. C., Capron M., Vorng H., Pancré V., Kusnierz J. P., Auriault C. The receptor for IgE on blood platelets. Eur J Immunol. 1986 Mar;16(3):306–312. doi: 10.1002/eji.1830160318. [DOI] [PubMed] [Google Scholar]
  12. Joseph M., Tonnel A. B., Torpier G., Capron A., Arnoux B., Benveniste J. Involvement of immunoglobulin E in the secretory processes of alveolar macrophages from asthmatic patients. J Clin Invest. 1983 Feb;71(2):221–230. doi: 10.1172/JCI110762. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Melewicz F. M., Spiegelberg H. L. Fc receptors for IgE on a subpopulation of human peripheral blood monocytes. J Immunol. 1980 Sep;125(3):1026–1031. [PubMed] [Google Scholar]
  14. Morley J., Sanjar S., Page C. P. The platelet in asthma. Lancet. 1984 Nov 17;2(8412):1142–1144. doi: 10.1016/s0140-6736(84)91567-8. [DOI] [PubMed] [Google Scholar]
  15. Mueller H. L. Diagnosis and treatment of insect sensitivity. J Asthma Res. 1966 Jun;3(4):331–333. doi: 10.3109/02770906609106941. [DOI] [PubMed] [Google Scholar]
  16. Nataf P., Guinnepain M. T., Herman D. Rush venom immunotherapy: a 3-day programme for hymenoptera sting allergy. Clin Allergy. 1984 May;14(3):269–275. doi: 10.1111/j.1365-2222.1984.tb02206.x. [DOI] [PubMed] [Google Scholar]
  17. Page C. P., Paul W., Morley J. Platelets and bronchospasm. Int Arch Allergy Appl Immunol. 1984;74(4):347–350. doi: 10.1159/000233571. [DOI] [PubMed] [Google Scholar]
  18. Pancré V., Auriault C., Joseph M., Cesbron J. Y., Kusnierz J. P., Capron A. A suppressive lymphokine of platelet cytotoxic functions. J Immunol. 1986 Jul 15;137(2):585–591. [PubMed] [Google Scholar]
  19. Patscheke H. Shape and functional properties of human platelets washed with acid citrate. Haemostasis. 1981;10(1):14–27. doi: 10.1159/000214383. [DOI] [PubMed] [Google Scholar]
  20. Rocklin R. E., Sheffer A. L., Greineder D. K., Melmon K. L. Generation of antigen-specific suppressor cells during allergy desensitization. N Engl J Med. 1980 May 29;302(22):1213–1219. doi: 10.1056/NEJM198005293022201. [DOI] [PubMed] [Google Scholar]
  21. Smith P. L., Kagey-Sobotka A., Bleecker E. R., Traystman R., Kaplan A. P., Gralnick H., Valentine M. D., Permutt S., Lichtenstein L. M. Physiologic manifestations of human anaphylaxis. J Clin Invest. 1980 Nov;66(5):1072–1080. doi: 10.1172/JCI109936. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Sobotka A. K., Valentine M. D., Benton A. W., Lichtenstein L. M. Allergy to insect stings. I. Diagnosis of IgE-mediated hymenoptera sensitivity by venom-induced histamine release. J Allergy Clin Immunol. 1974 Mar;53(3):170–184. doi: 10.1016/0091-6749(74)90005-0. [DOI] [PubMed] [Google Scholar]
  23. Sobotka A. K., Valentine M. D., Ishizaka K., Lichtenstein L. M. Measurement of IgG-blocking antibodies: development and application of a radioimmunoassay. J Immunol. 1976 Jul;117(1):84–90. [PubMed] [Google Scholar]
  24. Spiegelberg H. L. Lymphocytes bearing Fc receptors for IgE. Immunol Rev. 1981;56:199–218. doi: 10.1111/j.1600-065x.1981.tb01052.x. [DOI] [PubMed] [Google Scholar]
  25. Stevens W. J., Bridts C. H. IgG-containing and IgE-containing circulating immune complexes in patients with asthma and rhinitis. J Allergy Clin Immunol. 1984 Feb;73(2):276–282. doi: 10.1016/s0091-6749(84)80020-2. [DOI] [PubMed] [Google Scholar]

Articles from Clinical and Experimental Immunology are provided here courtesy of British Society for Immunology

RESOURCES