Skip to main content
NCBI home page
Clinical and Experimental Immunology logoLink to Clinical and Experimental Immunology
. 1988 Sep;73(3):348–354.

Abnormal monocyte chemotaxis in patients with chronic purulent rhinosinusitis: an effect of retroviral p15E-related factors in serum.

E M van de Plassche-Boers 1, M Tas 1, M de Haan-Meulman 1, M Kleingeld 1, H A Drexhage 1
PMCID: PMC1541775  PMID: 3264768

Abstract

Earlier we reported that about 60% of patients suffering from unexplained relapsing of chronic purulent rhinosinusitis show a defective T cell-mediated immunity to commensal microorganisms of the upper respiratory tract. The monocyte chemotactic responsiveness was assessed in 40 of these patients by means of the polarization assay. Impaired FMLP-induced monocyte polarization was found in 26 of the 40 patients tested. The defective chemotactic responsiveness could be explained by a p15E-related factor detectable in the serum of the patients: addition of serum fractions less than 25 kD to healthy donor monocytes resulted in an inhibition of polarization; a monoclonal antibody directed against p15E neutralized this inhibitory effect. In individual patients, a decreased monocyte polarization correlated well with the presence of this p15E-related factor in serum, as well as with defective T cell reactivity.

Full text

PDF
348

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Altman L. C., Furukawa C. T., Klebanoff S. J. Depressed mononuclear leukocyte chemotaxis in thermally injured patients. J Immunol. 1977 Jul;119(1):199–205. [PubMed] [Google Scholar]
  2. Balm F. J., Drexhage H. A., von Blomberg M. E., Snow G. B. Mononuclear phagocyte function in head and neck cancer: NBT-dye reduction, maturation and migration of peripheral blood monocytes. Laryngoscope. 1982 Jul;92(7 Pt 1):810–814. doi: 10.1288/00005537-198207000-00019. [DOI] [PubMed] [Google Scholar]
  3. Balm F. J., von Blomberg-van deFlier B. M., Drexhage H. A., de Haan-Meulman M., Snow G. B. Mononuclear phagocyte function in head and neck cancer: depression of murine macrophage accumulation by low molecular weight factors derived from head and neck carcinomas. Laryngoscope. 1984 Feb;94(2 Pt 1):223–227. doi: 10.1288/00005537-198402000-00016. [DOI] [PubMed] [Google Scholar]
  4. Benyunes M. C., Snyderman R. Characterization of an oligopeptide chemoattractant receptor on human blood monocytes using a new radioligand. Blood. 1984 Mar;63(3):588–592. [PubMed] [Google Scholar]
  5. Cianciolo G. J. Antiinflammatory proteins associated with human and murine neoplasms. Biochim Biophys Acta. 1986 Aug 5;865(1):69–82. doi: 10.1016/0304-419x(86)90014-4. [DOI] [PubMed] [Google Scholar]
  6. Cianciolo G. J., Copeland T. D., Oroszlan S., Snyderman R. Inhibition of lymphocyte proliferation by a synthetic peptide homologous to retroviral envelope proteins. Science. 1985 Oct 25;230(4724):453–455. doi: 10.1126/science.2996136. [DOI] [PubMed] [Google Scholar]
  7. Cianciolo G. J., Kipnis R. J., Snyderman R. Similarity between p15E of murine and feline leukaemia viruses and p21 of HTLV. Nature. 1984 Oct 11;311(5986):515–515. doi: 10.1038/311515a0. [DOI] [PubMed] [Google Scholar]
  8. Cianciolo G. J., Matthews T. J., Bolognesi D. P., Snyderman R. Macrophage accumulation in mice is inhibited by low molecular weight products from murine leukemia viruses. J Immunol. 1980 Jun;124(6):2900–2905. [PubMed] [Google Scholar]
  9. Cianciolo G. J., Phipps D., Snyderman R. Human malignant and mitogen-transformed cells contain retroviral P15E-related antigen. J Exp Med. 1984 Mar 1;159(3):964–969. doi: 10.1084/jem.159.3.964. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Cianciolo G. J., Snyderman R. Monocyte responsiveness to chemotactic stimuli is a property of a subpopulation of cells that can respond to multiple chemoattractants. J Clin Invest. 1981 Jan;67(1):60–68. doi: 10.1172/JCI110033. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Cianciolo G., Hunter J., Silva J., Haskill J. S., Snyderman R. Inhibitors of monocyte responses to chemotaxins are present in human cancerous effusions and react with monoclonal antibodies to the P15(E) structural protein of retroviruses. J Clin Invest. 1981 Oct;68(4):831–844. doi: 10.1172/JCI110338. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Copelan E. A., Rinehart J. J., Lewis M., Mathes L., Olsen R., Sagone A. The mechanism of retrovirus suppression of human T cell proliferation in vitro. J Immunol. 1983 Oct;131(4):2017–2020. [PubMed] [Google Scholar]
  13. Currie G. A., Hedley D. W. Monocytes and macrophages in malignant melanoma. I. Peripheral blood macrophage precursors. Br J Cancer. 1977 Jul;36(1):1–6. doi: 10.1038/bjc.1977.147. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Drexhage H. A., van de Plassche E. M., Kokjé M., Leezenberg H. A. Abnormalities in cell-mediated immune functions to Haemophilus influenzae chronic purulent infections of the upper respiratory tract. Clin Immunol Immunopathol. 1983 Aug;28(2):218–228. doi: 10.1016/0090-1229(83)90156-3. [DOI] [PubMed] [Google Scholar]
  15. Furukawa C. T., Altman L. C. Defective monocyte and polymorphonuclear leukocyte chemotaxis in atopic disease. J Allergy Clin Immunol. 1978 May;61(5):288–293. doi: 10.1016/0091-6749(78)90049-0. [DOI] [PubMed] [Google Scholar]
  16. Maderazo E. G., Anton T. F., Ward P. A. Serum-associated inhibition of leukotaxis in humans with cancer. Clin Immunol Immunopathol. 1978 Feb;9(2):166–176. doi: 10.1016/0090-1229(78)90068-5. [DOI] [PubMed] [Google Scholar]
  17. Mathes L. E., Olsen R. G., Hebebrand L. C., Hoover E. A., Schaller J. P. Abrogation of lymphocyte blastogenesis by a feline leukaemia virus protein. Nature. 1978 Aug 17;274(5672):687–689. doi: 10.1038/274687a0. [DOI] [PubMed] [Google Scholar]
  18. Mathes L. E., Olsen R. G., Hebebrand L. C., Hoover E. A., Schaller J. P., Adams P. W., Nichols W. S. Immunosuppressive properties of a virion polypeptide, a 15,000-dalton protein, from feline leukemia virus. Cancer Res. 1979 Mar;39(3):950–955. [PubMed] [Google Scholar]
  19. Mullink H., Von Blomberg M., Wilders M. M., Drexhage H. A., Alons C. L. A simple cytochemical method for distinguishing EAC rosettes formed by lymphocytes and monocytes. J Immunol Methods. 1979;29(2):133–137. doi: 10.1016/0022-1759(79)90062-0. [DOI] [PubMed] [Google Scholar]
  20. Pike M. C., Snyderman R. Depression of macrophage function by a factor produced by neoplasms: a merchanism for abrogation of immune surveillance. J Immunol. 1976 Oct;117(4):1243–1249. [PubMed] [Google Scholar]
  21. Poli G., Bottazzi B., Acero R., Bersani L., Rossi V., Introna M., Lazzarin A., Galli M., Mantovani A. Monocyte function in intravenous drug abusers with lymphadenopathy syndrome and in patients with acquired immunodeficiency syndrome: selective impairment of chemotaxis. Clin Exp Immunol. 1985 Oct;62(1):136–142. [PMC free article] [PubMed] [Google Scholar]
  22. Smith P. D., Ohura K., Masur H., Lane H. C., Fauci A. S., Wahl S. M. Monocyte function in the acquired immune deficiency syndrome. Defective chemotaxis. J Clin Invest. 1984 Dec;74(6):2121–2128. doi: 10.1172/JCI111637. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Snyderman R., Meadows L., Holder W., Wells S., Jr Abnormal monocyte chemotaxis in patients with breast cancer: evidence for a tumor-mediated effect. J Natl Cancer Inst. 1978 Apr;60(4):737–740. doi: 10.1093/jnci/60.4.737. [DOI] [PubMed] [Google Scholar]
  24. Snyderman R., Pike M. C. Chemoattractant receptors on phagocytic cells. Annu Rev Immunol. 1984;2:257–281. doi: 10.1146/annurev.iy.02.040184.001353. [DOI] [PubMed] [Google Scholar]
  25. Snyderman R., Rogers E., Buckley R. H. Abnormalities of leukotaxis in atopic dermatitis. J Allergy Clin Immunol. 1977 Aug;60(2):121–126. doi: 10.1016/0091-6749(77)90037-9. [DOI] [PubMed] [Google Scholar]
  26. Snyderman R., Seigler H. F., Meadows L. Abnormalitieis of monocyte chemotaxis in patients with melanoma: effects of immunotherapy and tumor removal. J Natl Cancer Inst. 1977 Jan;58(1):37–41. doi: 10.1093/jnci/58.1.37. [DOI] [PubMed] [Google Scholar]
  27. Tan I. B., Drexhage H. A., Scheper R. J., von Blomberg-van de Flier B. M., de Haan-Meulman M., Snow G. B., Balm F. J. Immunosuppressive retroviral P15E-related factors in head and neck carcinomas. Arch Otolaryngol Head Neck Surg. 1986 Sep;112(9):942–945. doi: 10.1001/archotol.1986.03780090038006. [DOI] [PubMed] [Google Scholar]
  28. Tan I. B., Drexhage H. A., Scheper R. J., von Blomberg-van der Flier B. M., de Haan-Meulman M., Snow G. B., Balm A. J. Defective monocyte chemotaxis in patients with head and neck cancer. Restoration after treatment. Arch Otolaryngol Head Neck Surg. 1986 May;112(5):541–544. doi: 10.1001/archotol.1986.03780050065011. [DOI] [PubMed] [Google Scholar]
  29. Tas M., Drexhage H. A., Goudsmit J. A monocyte chemotaxis inhibiting factor in serum of HIV infected men shares epitopes with the HIV transmembrane protein gp41. Clin Exp Immunol. 1988 Jan;71(1):13–18. [PMC free article] [PubMed] [Google Scholar]
  30. Ternowitz T., Herlin T. Defective monocyte and polymorphonuclear leukocyte chemotaxis and clinical characteristics in atopic dermatitis. Arch Dermatol Res. 1986;278(6):454–459. doi: 10.1007/BF00455163. [DOI] [PubMed] [Google Scholar]
  31. Van de Plassche-Boers E. M., Drexhage H. A., Kokjé-Kleingeld M. The use of somatic antigen of Haemophilus influenzae for the monitoring of T cell-mediated skin test reactivity in man. J Immunol Methods. 1985 Nov 7;83(2):353–361. doi: 10.1016/0022-1759(85)90257-1. [DOI] [PubMed] [Google Scholar]
  32. Weinberg J. B., Muscato J. J., Niedel J. E. Monocyte chemotactic peptide receptor. Functional characteristics and ligand-induced regulation. J Clin Invest. 1981 Sep;68(3):621–630. doi: 10.1172/JCI110296. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. Wilkinson P. C. The locomotor capacity of human lymphocytes and its enhancement by cell growth. Immunology. 1986 Feb;57(2):281–289. [PMC free article] [PubMed] [Google Scholar]
  34. van de Plassche-Boers E. M., Drexhage H. A., Kokjé-Kleingeld M., Leezenberg H. A. Parameters of T cell mediated immunity to commensal micro-organisms in patients with chronic purulent rhinosinusitis: a comparison between delayed type hypersensitivity skin test, lymphocyte transformation test and macrophage migration inhibition factor assay. Clin Exp Immunol. 1986 Dec;66(3):516–524. [PMC free article] [PubMed] [Google Scholar]

Articles from Clinical and Experimental Immunology are provided here courtesy of British Society for Immunology

RESOURCES