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. 1988 Nov;74(2):247–253.

Relationship between anti-cardiolipin and anti-endothelial cell antibodies in systemic lupus erythematosus

A Vismara, P L Meroni, Angela Tincani, E N Harris, Wilma Barcellini, A Brucato, M Khamashta, G R V Hughes, C Zanussi, G Balestrieri
PMCID: PMC1541785  PMID: 3224443

Abstract

Anti-endothelial cell antibodies (AECA) have been detected in 51 lupus sera by cell surface radioimmunoassay with a prevalence of 39·2% for IgG and 45·1% for IgM-AECA. No correlations were found between AECA and different clinical or laboratory parameters, including the presence of anti-cardiolipin antibodies and signs associated with the presence of anti-phospholipid antibodies. However, absorption with cardiolipin liposomes partially inhibited endothelial cell binding, and affinity purified anti-cardiolipin antibodies were able to react with intact human endothelial cells. The binding did not occur via Fc receptors since blocking of Fc receptors with rabbit IgG did not affect the endothelial cell reactivity. Taken together our findings support the hypothesis that antibodies directed against negatively charged phospholipids can be part of the anti-endothelial cell antibodies in certain lupus sera. The possible role of these cross-reacting antibodies in the pathogenesis of vascular thrombosis in lupus patients is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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