Skip to main content
PMC home page
Clinical and Experimental Immunology logoLink to Clinical and Experimental Immunology
. 1988 Nov;74(2):177–181.

Role of retroviruses in acquired hypogammaglobulinaemia.

G P Spickett 1, M Millrain 1, R Beattie 1, M North 1, J Griffiths 1, S Patterson 1, A D Webster 1
PMCID: PMC1541807  PMID: 2465107

Abstract

Mononuclear cells were obtained from 42 patients with 'common variable' hypogammaglobulinaemia (CVH) and co-cultured with various cell lines in an attempt to isolate retroviruses. Cultures from only two patients showed evidence of a viral infection, although the virus could not be isolated and characterized in either. Despite the previous isolation of HIV's from two other CVH patients, this data suggests that similar viruses are not etiologically involved in the majority of patients.

Full text

PDF
177

Images in this article

178Fig. 1
on p.178
179Fig. 2
on p.179

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Barré-Sinoussi F., Chermann J. C., Rey F., Nugeyre M. T., Chamaret S., Gruest J., Dauguet C., Axler-Blin C., Vézinet-Brun F., Rouzioux C. Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS). Science. 1983 May 20;220(4599):868–871. doi: 10.1126/science.6189183. [DOI] [PubMed] [Google Scholar]
  2. Clavel F., Guyader M., Guétard D., Sallé M., Montagnier L., Alizon M. Molecular cloning and polymorphism of the human immune deficiency virus type 2. Nature. 1986 Dec 18;324(6098):691–695. doi: 10.1038/324691a0. [DOI] [PubMed] [Google Scholar]
  3. Douglas S. D., Goldberg L. S., Fudenberg H. H. Clinical, serologic and leukocyte function studies on patients with idiopathic "acquired" agammaglobulinemia and their families. Am J Med. 1970 Jan;48(1):48–53. doi: 10.1016/0002-9343(70)90097-5. [DOI] [PubMed] [Google Scholar]
  4. Farrant J., Bryant A. E., Lever A. M., Edwards A. J., Knight S. C., Webster A. D. Defective low-density cells of dendritic morphology from the blood of patients with common variable hypogammaglobulinaemia: low immunoglobulin production on stimulation of normal B cells. Clin Exp Immunol. 1985 Jul;61(1):189–194. [PMC free article] [PubMed] [Google Scholar]
  5. Gendelman H. E., Orenstein J. M., Martin M. A., Ferrua C., Mitra R., Phipps T., Wahl L. A., Lane H. C., Fauci A. S., Burke D. S. Efficient isolation and propagation of human immunodeficiency virus on recombinant colony-stimulating factor 1-treated monocytes. J Exp Med. 1988 Apr 1;167(4):1428–1441. doi: 10.1084/jem.167.4.1428. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Hahn B. H., Shaw G. M., Arya S. K., Popovic M., Gallo R. C., Wong-Staal F. Molecular cloning and characterization of the HTLV-III virus associated with AIDS. Nature. 1984 Nov 8;312(5990):166–169. doi: 10.1038/312166a0. [DOI] [PubMed] [Google Scholar]
  7. Hoffman A. D., Banapour B., Levy J. A. Characterization of the AIDS-associated retrovirus reverse transcriptase and optimal conditions for its detection in virions. Virology. 1985 Dec;147(2):326–335. doi: 10.1016/0042-6822(85)90135-7. [DOI] [PubMed] [Google Scholar]
  8. Kinlen L. J., Webster A. D., Bird A. G., Haile R., Peto J., Soothill J. F., Thompson R. A. Prospective study of cancer in patients with hypogammaglobulinaemia. Lancet. 1985 Feb 2;1(8423):263–266. doi: 10.1016/s0140-6736(85)91037-2. [DOI] [PubMed] [Google Scholar]
  9. Lever A. M., Webster A. D., Brown D., Thomas H. C. Non-A, non-B hepatitis occurring in agammaglobulinaemic patients after intravenous immunoglobulin. Lancet. 1984 Nov 10;2(8411):1062–1064. doi: 10.1016/s0140-6736(84)91506-x. [DOI] [PubMed] [Google Scholar]
  10. Maloney M. J., Guill M. F., Wray B. B., Lobel S. A., Ebbeling W. Pediatric acquired immune deficiency syndrome with panhypogammaglobulinemia. J Pediatr. 1987 Feb;110(2):266–267. doi: 10.1016/s0022-3476(87)80170-1. [DOI] [PubMed] [Google Scholar]
  11. Morell A., Barandun S., Locher G. HTLV-III seroconversion in a homosexual patient with common variable immunodeficiency. N Engl J Med. 1986 Aug 14;315(7):456–457. doi: 10.1056/NEJM198608143150712. [DOI] [PubMed] [Google Scholar]
  12. Pahwa R., Good R. A., Pahwa S. Prematurity, hypogammaglobulinemia, and neuropathology with human immunodeficiency virus (HIV) infection. Proc Natl Acad Sci U S A. 1987 Jun;84(11):3826–3830. doi: 10.1073/pnas.84.11.3826. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Platts-Mills T. A., De Gast G. C., Webster A. D., Asherson G. L., Wilkins S. R. Two immunologically distinct forms of late-onset hypogammaglobulinaemia. Clin Exp Immunol. 1981 May;44(2):383–388. [PMC free article] [PubMed] [Google Scholar]
  14. Prince A. M., Piët M. P., Horowitz B. Effect of Cohn fractionation conditions on infectivity of the AIDS virus. N Engl J Med. 1986 Feb 6;314(6):386–387. doi: 10.1056/NEJM198602063140613. [DOI] [PubMed] [Google Scholar]
  15. Uchiyama T., Yodoi J., Sagawa K., Takatsuki K., Uchino H. Adult T-cell leukemia: clinical and hematologic features of 16 cases. Blood. 1977 Sep;50(3):481–492. [PubMed] [Google Scholar]
  16. Webster A. D., Asherson G. L. Identification and function of T cells in the peripheral blood of patients with hypogammaglobulinaemia. Clin Exp Immunol. 1974 Dec;18(4):499–504. [PMC free article] [PubMed] [Google Scholar]
  17. Webster A. D., Dalgleish A. G., Malkovsky M., Beattie R., Patterson S., Asherson G. L., North M., Weiss R. A. Isolation of retroviruses from two patients with "common variable" hypogammaglobulinaemia. Lancet. 1986 Mar 15;1(8481):581–583. doi: 10.1016/s0140-6736(86)92809-6. [DOI] [PubMed] [Google Scholar]
  18. Webster A. D., Latif A. A., Brenner M. K., Bird D. Evaluation of test immunisation in the assessment of antibody deficiency syndromes. Br Med J (Clin Res Ed) 1984 Jun 23;288(6434):1864–1866. doi: 10.1136/bmj.288.6434.1864. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Webster A. D., Platts-Mills T. A., Jannossy G., Morgan M., Asherson G. L. Autoimmune blood dyscrasias in five patients with hypogammaglobulinemia: response of neutropenia to vincristine. J Clin Immunol. 1981 Apr;1(2):113–118. doi: 10.1007/BF00915388. [DOI] [PubMed] [Google Scholar]
  20. Wong-Staal F., Shaw G. M., Hahn B. H., Salahuddin S. Z., Popovic M., Markham P., Redfield R., Gallo R. C. Genomic diversity of human T-lymphotropic virus type III (HTLV-III). Science. 1985 Aug 23;229(4715):759–762. doi: 10.1126/science.2992084. [DOI] [PubMed] [Google Scholar]
  21. Wright J. J., Birx D. L., Wagner D. K., Waldmann T. A., Blaese R. M., Fleisher T. A. Normalization of antibody responsiveness in a patient with common variable hypogammaglobulinemia and HIV infection. N Engl J Med. 1987 Dec 10;317(24):1516–1520. doi: 10.1056/NEJM198712103172406. [DOI] [PubMed] [Google Scholar]

Articles from Clinical and Experimental Immunology are provided here courtesy of British Society for Immunology

RESOURCES