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. 1989 Jan;75(1):41–46.

Anti-lymphocytic antibodies in autoimmune chronic active hepatitis starting in childhood.

P T Donaldson 1, M J Hussain 1, G Mieli-Vergani 1, A P Mowat 1, D Vergani 1
PMCID: PMC1541856  PMID: 2784729

Abstract

Anti-lymphocytic antibodies (ALA) have been described in a variety of autoimmune disorders. We have investigated the presence of ALA in autoimmune chronic active hepatitis (aCAH) starting in childhood. Using a modified Terasaki technique ALA were found in 17 of 18 patients with aCAH but in only one of 15 patients with alpha-1-anti-trypsin deficiency or Wilson's disease and three of 27 age-matched healthy controls (P less than 0.0005 for both). Sera from 12 patients with uncontrolled aCAH had significantly higher cytotoxicity values than sera from six children with inactive diseases (P less than 0.01). ALA were directed to T but not B lymphocytes and were not reactive with specific HLA antigens. No preferential killing was observed against CD4 or CD8 positive T lymphocytes. Characterization of ALA revealed them to be cold-reactive IgM. The possible role of ALA in aCAH is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Dehoratius R. J., Henderson C., Strickland R. G. Lymphocytotoxins in acute and chronic hepatitis. Characterization and relationship to changes in circulating T lymphocytes. Clin Exp Immunol. 1976 Oct;26(1):21–27. [PMC free article] [PubMed] [Google Scholar]
  2. Kashio T., Hotta R., Kakumu S. Lymphocyte suppressor cell activity in acute and chronic liver disease. Clin Exp Immunol. 1981 Jun;44(3):459–466. [PMC free article] [PubMed] [Google Scholar]
  3. Klassen L. W., Krakauer R. S., Steinberg A. D. Selective loss of suppressor cell function in New Zealand mice induced by NTA. J Immunol. 1977 Sep;119(3):830–830. [PubMed] [Google Scholar]
  4. Lobo-Yeo A., Alviggi L., Mieli-Vergani G., Portmann B., Mowat A. P., Vergani D. Preferential activation of helper/inducer T lymphocytes in autoimmune chronic active hepatitis. Clin Exp Immunol. 1987 Jan;67(1):95–104. [PMC free article] [PubMed] [Google Scholar]
  5. McFarlane I. G., Williams R. Liver membrane antibodies. J Hepatol. 1985;1(3):313–319. doi: 10.1016/s0168-8278(85)80058-1. [DOI] [PubMed] [Google Scholar]
  6. Morimoto C., Abe T., Toguchi T., Kiyotaki M., Homma M. Studies of anti-lymphocyte antibody of patients with active SLE. I. Cause of loss of suppressor T-lymphocyte function. Scand J Immunol. 1979;10(3):213–221. doi: 10.1111/j.1365-3083.1979.tb01342.x. [DOI] [PubMed] [Google Scholar]
  7. Morimoto C., Letvin N. L., Distaso J. A., Aldrich W. R., Schlossman S. F. The isolation and characterization of the human suppressor inducer T cell subset. J Immunol. 1985 Mar;134(3):1508–1515. [PubMed] [Google Scholar]
  8. Nouri-Aria K. T., Lobo-Yeo A., Vergani D., Mieli-Vergani G., Eddleston A. L., Mowat A. P. T suppressor cell function and number in children with liver disease. Clin Exp Immunol. 1985 Aug;61(2):283–289. [PMC free article] [PubMed] [Google Scholar]
  9. Okudaira K., Nakai H., Hayakawa T., Kashiwado T., Tanimoto K., Horiuchi Y., Juji T. Detection of antilymphocyte antibody with two-color method in systemic lupus erythematosus and its heterogeneous specificities against human T-cell subsets. J Clin Invest. 1979 Nov;64(5):1213–1220. doi: 10.1172/JCI109575. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Okudaira K., Searles R. P., Ceuppens J. L., Goodwin J. S., Williams R. C., Jr Anti-Ia reactivity in sera from patients with systemic lupus erythematosus. J Clin Invest. 1982 Jan;69(1):17–24. doi: 10.1172/JCI110428. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Parés A., Martorell J., Caballería J., Vives J., Bruguera M., Rodés J. Lymphocytotoxic antibodies in primary biliary cirrhosis. Dig Dis Sci. 1985 Sep;30(9):829–833. doi: 10.1007/BF01309512. [DOI] [PubMed] [Google Scholar]
  12. Robertson D. A., Zhang S. L., Guy E. C., Wright R. Persistent measles virus genome in autoimmune chronic active hepatitis. Lancet. 1987 Jul 4;2(8549):9–11. doi: 10.1016/s0140-6736(87)93051-0. [DOI] [PubMed] [Google Scholar]
  13. Sakane T., Steinberg A. D., Reeves J. P., Green I. Studies of immune functions of patients with systemic lupus erythematosus. Complement-dependent immunoglobulin M anti-thymus-derived cell antibodies preferentially inactivate suppressor cells. J Clin Invest. 1979 May;63(5):954–965. doi: 10.1172/JCI109396. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Vento S., Hegarty J. E., Bottazzo G., Macchia E., Williams R., Eddleston A. L. Antigen specific suppressor cell function in autoimmune chronic active hepatitis. Lancet. 1984 Jun 2;1(8388):1200–1204. doi: 10.1016/s0140-6736(84)91691-x. [DOI] [PubMed] [Google Scholar]
  15. Winfield J. B., Shaw M., Yamada A., Minota S. Subset specificity of antilymhocyte antibodies in systemic lupus erythematosus. II. Preferential reactivity with T4 + cells is associated with relative depletion of autologous T4 + cells. Arthritis Rheum. 1987 Feb;30(2):162–168. doi: 10.1002/art.1780300206. [DOI] [PubMed] [Google Scholar]
  16. Yamada A., Cohen P. L., Winfield J. B. Subset specificity of antilymphocyte antibodies in systemic lupus erythematosus. Preferential reactivity with cells bearing the T4 and autologous erythrocyte receptor phenotypes. Arthritis Rheum. 1985 Mar;28(3):262–270. doi: 10.1002/art.1780280305. [DOI] [PubMed] [Google Scholar]

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