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. 1989 Jan;75(1):136–140.

Immunological aspects of cerebral lesions in murine malaria.

J H Curfs 1, T P Schetters 1, C C Hermsen 1, C R Jerusalem 1, A A van Zon 1, W M Eling 1
PMCID: PMC1541862  PMID: 2649283

Abstract

The majority of male C57Bl/Rij mice died infected with Plasmodium berghei early in the second week. Death was closely correlated to collapse of the thermoregulation of the body, with perivascular oedema and petechial haemorrhages in the brain. Mice that did not show a collapse of thermoregulation (temperature drop below 30 degrees C) and survived for more than 2 weeks after infection did not show haemorrhages. Development of this syndrome (temperature below 30 degrees C; early death; haemorrhages) during infection depended on the presence of the spleen and was prevented by irradiation of the spleen or a timely treatment with dexamethasone, anti-T-cell serum or immune serum.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Beutler B., Krochin N., Milsark I. W., Luedke C., Cerami A. Control of cachectin (tumor necrosis factor) synthesis: mechanisms of endotoxin resistance. Science. 1986 May 23;232(4753):977–980. doi: 10.1126/science.3754653. [DOI] [PubMed] [Google Scholar]
  2. Dinarello C. A., Cannon J. G., Wolff S. M., Bernheim H. A., Beutler B., Cerami A., Figari I. S., Palladino M. A., Jr, O'Connor J. V. Tumor necrosis factor (cachectin) is an endogenous pyrogen and induces production of interleukin 1. J Exp Med. 1986 Jun 1;163(6):1433–1450. doi: 10.1084/jem.163.6.1433. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Eling W. M., Jerusalem C. R., Heinen-Borries U. Role of macrophages in the pathogenesis of endomyocardial fibrosis in murine malaria. Trans R Soc Trop Med Hyg. 1984;78(1):43–48. doi: 10.1016/0035-9203(84)90169-x. [DOI] [PubMed] [Google Scholar]
  4. Eling W., Jerusalem C. Active immunization against the malaria parasite Plasmodium berghei in mice: sulfathiazole treatment of a P. berghei infection and development of immunity. Tropenmed Parasitol. 1977 Jun;28(2):158–174. [PubMed] [Google Scholar]
  5. Finley R. W., Mackey L. J., Lambert P. H. Virulent P. berghei malaria: prolonged survival and decreased cerebral pathology in cell-dependent nude mice. J Immunol. 1982 Nov;129(5):2213–2218. [PubMed] [Google Scholar]
  6. Grau G. E., Fajardo L. F., Piguet P. F., Allet B., Lambert P. H., Vassalli P. Tumor necrosis factor (cachectin) as an essential mediator in murine cerebral malaria. Science. 1987 Sep 4;237(4819):1210–1212. doi: 10.1126/science.3306918. [DOI] [PubMed] [Google Scholar]
  7. Grau G. E., Piguet P. F., Engers H. D., Louis J. A., Vassalli P., Lambert P. H. L3T4+ T lymphocytes play a major role in the pathogenesis of murine cerebral malaria. J Immunol. 1986 Oct 1;137(7):2348–2354. [PubMed] [Google Scholar]
  8. Polder T., Jerusalem C., Eling W. Topographical distribution of the cerebral lesions in mice infected with Plasmodium berghei. Tropenmed Parasitol. 1983 Dec;34(4):235–243. [PubMed] [Google Scholar]
  9. Rest J. R. Pathogenesis of cerebral malaria in golden hamsters and inbred mice. Contrib Microbiol Immunol. 1983;7:139–146. [PubMed] [Google Scholar]
  10. Wright D. H., Masembe R. M., Bazira E. R. The effect of antithymocyte serum on golden hamsters and rats infected with Plasmodium berghei. Br J Exp Pathol. 1971 Oct;52(5):465–477. [PMC free article] [PubMed] [Google Scholar]
  11. Wright D. H. The effect of neonatal thymectomy on the survival of golden hamsters infected with Plasmodium berghei. Br J Exp Pathol. 1968 Aug;49(4):379–384. [PMC free article] [PubMed] [Google Scholar]

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