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. 1989 Jul;77(1):43–46.

Circulating colony-forming units of granulocytes and monocytes/macrophages in systemic lupus erythematosus.

X López-Karpovitch 1, M Cardiel 1, R Cardenas 1, J Piedras 1, D Alarcón-Segovia 1
PMCID: PMC1541920  PMID: 2766577

Abstract

In systemic lupus erythematosus (SLE) patients, in vitro bone marrow (BM) colony-forming units of granulocytes and monocytes/macrophages (CFU-GM) are decreased, suggesting that granulomonopoietic failure may play an important role in the mechanism of peripheral blood (PB) depletion of neutrophils and monocytes. No information concerning CFU-GM in PB of patients with SLE is available. The present study was undertaken in order to determine whether SLE itself and the inactive or active stage of disease would modify the number of GFU-GM in PB samples from 20 treatment-free SLE women, 12 inactive and eight active. CFU-GM growth was significantly decreased in both inactive (P = 0.018) and active (P = 0.008) SLE patients as compared with controls (n = 8). The difference in CFU-GM growth between SLE groups was not significant. These results indicate that the number of circulating CFU-GM is significantly reduced in patients with SLE regardless of disease activity or remission.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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