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. 1989 Jul;77(1):58–61.

Defective antibody-dependent tumour cell lysis by neutrophils from cancer patients.

F Dallegri 1, A Ballestrero 1, L Ottonello 1, F Patrone 1
PMCID: PMC1541921  PMID: 2766579

Abstract

Neutrophil antibody-dependent cellular cytotoxicity (ADCC) against Raji target cells was studied in 32 patients with lung or gastro-intestinal carcinoma and 25 healthy controls. Seventeen of the patients (53%) had defective ADCC. Moreover, neutrophils obtained from patients with defective ADCC were found to bind IgG-coated target cells normally. Thus, the defect responsible for the impaired lysis appears to be distal to the Fc receptor (FcR)-mediated target cell binding by neutrophils.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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