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Clinical and Experimental Immunology logoLink to Clinical and Experimental Immunology
. 1989 Mar;75(3):457–460.

Insulin autoantibodies in non-obese diabetic (NOD) mice.

C Michel 1, C Boitard 1, J F Bach 1
PMCID: PMC1541951  PMID: 2649293

Abstract

Anti-insulin autoantibodies were detected in NOD mice using ELISA. The antibodies were detected as early as at 5 weeks of age, long before onset of clinically overt diabetes, especially in diabetes-prone female mice. The anti-insulin specificity was verified by passage on affinity chromatography insulin columns and demonstration that the anti-insulin activity was located on the F(ab')2 region of the immunoglobulins. The presence of anti-insulin antibodies in prediabetic NOD mice provides a unique possibility for studying their significance and their eventual pathogenic role in the development of insulin-dependent diabetes.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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