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Clinical and Experimental Immunology logoLink to Clinical and Experimental Immunology
. 1989 Mar;75(3):427–431.

Modulation of collagen synthesis in human glomerular epithelial cells by interleukin 1.

I Torbohm 1, B Berger 1, M Schönermark 1, J von Kempis 1, K Rother 1, G M Hänsch 1
PMCID: PMC1541959  PMID: 2784746

Abstract

Human glomerular epithelial cells produce matrix material e.g. collagen type IV. In vitro, the synthesis of collagen can be monitored by the incorporation of 3H-proline, a precursor molecule of the collagens. We report on the enhancement of collagen synthesis by glomerular epithelial cells with highly purified or recombinant I1-1. Since I1-1 is released from monocytes or glomerular mesangial cells by inflammatory mediators, our results point to a participation of I1-1 in the development of sclerosis, which is seen in many forms of chronic inflammatory diseases.

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Selected References

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