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. 1989 Sep;77(3):345–348.

Serum interleukin-2-receptor in coeliac disease: response to treatment and gluten challenge.

J E Crabtree 1, R V Heatley 1, L D Juby 1, P D Howdle 1, M S Losowsky 1
PMCID: PMC1542053  PMID: 2805405

Abstract

Concentrations of the soluble interleukin-2 receptor (sIL-2R) in the serum of 33 patients with coeliac disease were measured by ELISA. The levels of sIL-2R were significantly raised in 15 patients with untreated coeliac disease compared with treated patients and age- and sex-matched symptomatic and non-symptomatic control groups. Longitudinal studies in individual coeliac patients showed that serum sIL-2R fell following commencement of a gluten-free diet. Gluten challenge of 16 treated coeliac patients for 1 week resulted in a significant increase in serum sIL-2R, which returned to prechallenge levels within 4 weeks of recommencement of a gluten-free diet. We suggest that serum sIL-2R levels in patients with coeliac disease reflect specific immunological activation in response to gluten ingestion. Measurement of serum sIL-2R may therefore be useful in the assessment of response to treatment in patients with coeliac disease.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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