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. 1989 Sep;77(3):403–409.

Monocyte-mediated suppression of anti-DNA antibody production in healthy subjects.

M Okawa-Takatsuji 1, S Aotsuka 1, S Uwatoko 1, M Kinoshita 1, R Yokohari 1
PMCID: PMC1542055  PMID: 2805410

Abstract

Monocyte-depleted mononuclear cells (MNC) from healthy subjects synthesized IgM-class antibody to single-stranded DNA (anti-ssDNA) at significantly higher levels than unfractionated MNC. The increased production of IgM anti-ssDNA by monocyte-depleted normal MNC was inhibited to a greater degree than total IgM by addition of supernatants from autologous monocytes. Moreover, supernatants obtained from normal monocytes cultured with indomethacin retained this suppressive effect on IgM anti-ssDNA antibody production, suggesting that prostaglandin E2 may not be involved in the suppression. These results indicate that B cells programmed to produce IgM anti-ssDNA are present in the normal B cell repertoire, but may be suppressed by monocytes or by a soluble factor (or factors) from the monocytes.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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