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. 1987 Nov;70(2):411–416.

Evidence of impaired antigen non-specific but normal antigen specific suppressor cell function in children with autoimmune chronic active hepatitis.

A Lobo-Yeo 1, G Mieli-Vergani 1, G Kenna 1, A P Mowat 1, D Vergani 1
PMCID: PMC1542095  PMID: 2448074

Abstract

In autoimmune chronic active hepatitis (aCAH), autoaggression is believed to derive from a defect in immunoregulation. Antigen non-specific Concanavalin A (Con A) induced suppressor cell function has been reported to be impaired. In 11 children with aCAH we have investigated inhibition of production of a specific antibody (anti-tetanus toxoid, anti-TT) by suppressor cells induced either by a non-specific stimulus (Con A) or by the specific antigen (tetanus toxoid, TT). Con A induced suppression of anti-TT was significantly lower in patients (15.7 +/- 2.5%) than in controls (46.7 +/- 4.4%; P less than 0.01). In contrast, high dose tetanus toxoid induced suppression was similar in patients and controls (69.8 +/- 4.2, 72.0 +/- 3.6%, respectively). Both groups had similar serum anti-TT levels and in vitro production of anti-TT in response to optimal dose of TT. Our data indicate that antibody production to a T cell-dependent antigen is under the control of at least two regulatory mechanisms, one antigen specific and one antigen non-specific, only the latter being defective in aCAH.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alexander G. J., Nouri-Aria K. T., Eddleston A. L., Williams R. Contrasting relations between suppressor-cell function and suppressor-cell number in chronic liver disease. Lancet. 1983 Jun 11;1(8337):1291–1293. doi: 10.1016/s0140-6736(83)92410-8. [DOI] [PubMed] [Google Scholar]
  2. Bresnihan B., Jasin H. E. Suppressor function of peripheral blood mononuclear cells in normal individuals and in patients with systemic lupus erythematosus. J Clin Invest. 1977 Jan;59(1):106–116. doi: 10.1172/JCI108607. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Galbraith R. M., Smith M., Mackenzie R. M., Tee D. E., Doniach D., Williams R. High prevalence of seroimmunologic abnormalities in relatives of patients with active chronic hepatitis or primary biliary cirrhosis. N Engl J Med. 1974 Jan 10;290(2):63–69. doi: 10.1056/NEJM197401102900201. [DOI] [PubMed] [Google Scholar]
  4. Jensen D. M., McFarlane I. G., Portmann B. S., Eddleston A. L., Williams R. Detection of antibodies directed against a liver-specific membrane lipoprotein in patients with acute and chronic active hepatitis. N Engl J Med. 1978 Jul 6;299(1):1–7. doi: 10.1056/NEJM197807062990101. [DOI] [PubMed] [Google Scholar]
  5. Kakumu S., Yata K., Kashio T. Immunoregulatory T-cell function in acute and chronic liver disease. Gastroenterology. 1980 Oct;79(4):613–619. [PubMed] [Google Scholar]
  6. Kashio T., Hotta R., Kakumu S. Lymphocyte suppressor cell activity in acute and chronic liver disease. Clin Exp Immunol. 1981 Jun;44(3):459–466. [PMC free article] [PubMed] [Google Scholar]
  7. McFarlane I. G., Wojcicka B. M., Williams R. Antigens of the human liver. Clin Exp Immunol. 1980 Apr;40(1):1–7. [PMC free article] [PubMed] [Google Scholar]
  8. Morimoto C., Reinherz E. L., Todd R. F., Distaso J. A., Schlossman S. F. Generation of antigen-specific suppressor cells in vitro in man. J Immunol. 1983 Sep;131(3):1209–1213. [PubMed] [Google Scholar]
  9. Nouri-Aria K. T., Donaldson P. T., Hegarty J. E., Eddleston A. L., Williams R. HLA A1-B8-DR3 and suppressor cell function in first-degree relatives of patients with autoimmune chronic active hepatitis. J Hepatol. 1985;1(3):235–241. doi: 10.1016/s0168-8278(85)80051-9. [DOI] [PubMed] [Google Scholar]
  10. Nouri-Aria K. T., Hegarty J. E., Alexander G. J., Eddleston A. L., Williams R. Effect of corticosteroids on suppressor-cell activity in "autoimmune" and viral chronic active hepatitis. N Engl J Med. 1982 Nov 18;307(21):1301–1304. doi: 10.1056/NEJM198211183072102. [DOI] [PubMed] [Google Scholar]
  11. Nouri-Aria K. T., Lobo-Yeo A., Vergani D., Mieli-Vergani G., Eddleston A. L., Mowat A. P. T suppressor cell function and number in children with liver disease. Clin Exp Immunol. 1985 Aug;61(2):283–289. [PMC free article] [PubMed] [Google Scholar]
  12. Pacini F., DeGroot L. J. Studies of immunoglobulin synthesis in cultures of peripheral T and B lymphocytes: reduced T-suppressor cell activity in Graves' disease. Clin Endocrinol (Oxf) 1983 Mar;18(3):219–232. doi: 10.1111/j.1365-2265.1983.tb03206.x. [DOI] [PubMed] [Google Scholar]
  13. Pedersen J. S., Toh B. H., Mackay I. R., Tait B. D., Gust I. D., Kastelan A., Hadzic N. Segregation of autoantibody to cytoskeletal filaments, actin and intermediate filaments with two types of chronic active hepatitis. Clin Exp Immunol. 1982 Jun;48(3):527–532. [PMC free article] [PubMed] [Google Scholar]
  14. Scheuer P. J. Chronic hepatitis: a problem for the pathologist. Histopathology. 1977 Jan;1(1):5–19. doi: 10.1111/j.1365-2559.1977.tb01640.x. [DOI] [PubMed] [Google Scholar]
  15. Shou L., Schwartz S. A., Good R. A. Suppressor cell activity after concanavalin A treatment of lymphocytes from normal donors. J Exp Med. 1976 May 1;143(5):1100–1110. doi: 10.1084/jem.143.5.1100. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Vento S., Hegarty J. E., Bottazzo G., Macchia E., Williams R., Eddleston A. L. Antigen specific suppressor cell function in autoimmune chronic active hepatitis. Lancet. 1984 Jun 2;1(8388):1200–1204. doi: 10.1016/s0140-6736(84)91691-x. [DOI] [PubMed] [Google Scholar]
  17. Volkman D. J., Allyn S. P., Fauci A. S. Antigen-induced in vitro antibody production in humans: tetanus toxoid-specific antibody synthesis. J Immunol. 1982 Jul;129(1):107–112. [PubMed] [Google Scholar]

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