Skip to main content
PMC home page
Clinical and Experimental Immunology logoLink to Clinical and Experimental Immunology
. 1989 Feb;75(2):167–177.

Immune suppression genes.

D B Oliveira 1, N A Mitchison 1
PMCID: PMC1542112  PMID: 2467772

Full text

PDF
167

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Adorini L., Harvey M. A., Miller A., Sercarz E. E. Fine specificity of regulatory T cells. II. Suppressor and helper T cells are induced by different regions of hen egg-white lysozyme in a genetically nonresponder mouse strain. J Exp Med. 1979 Aug 1;150(2):293–306. doi: 10.1084/jem.150.2.293. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Akbar A. N., Terry L., Timms A., Beverley P. C., Janossy G. Loss of CD45R and gain of UCHL1 reactivity is a feature of primed T cells. J Immunol. 1988 Apr 1;140(7):2171–2178. [PubMed] [Google Scholar]
  3. Araneo B. A., Yowell R. L. MHC-linked immune response suppression mediated by T cells bearing I-A-encoded determinants. J Immunol. 1985 Jul;135(1):73–79. [PubMed] [Google Scholar]
  4. Araneo B. A., Yowell R. L., Sercarz E. E. Recognition and display of the predominant idiotype among members of the regulatory circuitry controlling the anti-lysozyme immune response. J Immunol. 1985 Feb;134(2):1073–1079. [PubMed] [Google Scholar]
  5. Arthur R. P., Mason D. T cells that help B cell responses to soluble antigen are distinguishable from those producing interleukin 2 on mitogenic or allogeneic stimulation. J Exp Med. 1986 Apr 1;163(4):774–786. doi: 10.1084/jem.163.4.774. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Asherson G. L., Colizzi V., Zembala M. An overview of T-suppressor cell circuits. Annu Rev Immunol. 1986;4:37–68. doi: 10.1146/annurev.iy.04.040186.000345. [DOI] [PubMed] [Google Scholar]
  7. Baxevanis C. N., Ioannides C. D., Reclos G. J., Papamichail M. Evidence for distinct epitopes on human IgG with T cell proliferative and suppressor function. Eur J Immunol. 1986 Aug;16(8):1013–1016. doi: 10.1002/eji.1830160824. [DOI] [PubMed] [Google Scholar]
  8. Baxevanis C. N., Ishii N., Nagy Z. A., Klein J. H-2-controlled suppression of T cell response to lactate dehydrogenase B. Characterization of the lactate dehydrogenase B suppressor pathway. J Exp Med. 1982 Sep 1;156(3):822–833. doi: 10.1084/jem.156.3.822. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Baxevanis C. N., Nagy Z. A., Klein J. A novel type of T-T cell interaction removes the requirement for I-B region in the H-2 complex. Proc Natl Acad Sci U S A. 1981 Jun;78(6):3809–3813. doi: 10.1073/pnas.78.6.3809. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Beller D. I. Functional significance of the regulation of macrophage Ia expression. Eur J Immunol. 1984 Feb;14(2):138–143. doi: 10.1002/eji.1830140207. [DOI] [PubMed] [Google Scholar]
  11. Beverley P. C. Human T cell subsets. Immunol Lett. 1987 Apr;14(4):263–267. doi: 10.1016/0165-2478(87)90001-0. [DOI] [PubMed] [Google Scholar]
  12. Blackwell J. M., Roberts M. B. Immunomodulation of murine visceral leishmaniasis by administration of monoclonal anti-Ia antibodies: differential effects of anti-I-A vs. anti-I-E antibodies. Eur J Immunol. 1987 Nov;17(11):1669–1672. doi: 10.1002/eji.1830171125. [DOI] [PubMed] [Google Scholar]
  13. Bogen B. Dominant suppressive effect of the silent Eb alpha allele on an in vivo T helper cell response under Ed beta Ed alpha region-linked immune response gene control. Eur J Immunol. 1985 Oct;15(10):1033–1037. doi: 10.1002/eji.1830151014. [DOI] [PubMed] [Google Scholar]
  14. Cantor H., Gershon R. K. Immunological circuits: cellular composition. Fed Proc. 1979 Jun;38(7):2058–2064. [PubMed] [Google Scholar]
  15. Cinader B., Koh S. W., Naylor D. Tolerance-mediated inheritance of immune responsiveness. Int Arch Allergy Appl Immunol. 1969;35(2):150–162. doi: 10.1159/000230168. [DOI] [PubMed] [Google Scholar]
  16. Damle N. K., Childs A. L., Doyle L. V. Immunoregulatory T lymphocytes in man. Soluble antigen-specific suppressor-inducer T lymphocytes are derived from the CD4+CD45R-p80+ subpopulation. J Immunol. 1987 Sep 1;139(5):1501–1508. [PubMed] [Google Scholar]
  17. Damle N. K., Mohagheghpour N., Engleman E. G. Activation of antigen-specific suppressor T lymphocytes in man involves dual recognition of self class I MHC molecules and Leu-4/T3-associated structures on the surface of inducer T lymphocytes. J Immunol. 1984 Sep;133(3):1235–1240. [PubMed] [Google Scholar]
  18. Damle N. K., Mohagheghpour N., Engleman E. G. Soluble antigen-primed inducer T cells activate antigen-specific suppressor T cells in the absence of antigen-pulsed accessory cells: phenotypic definition of suppressor-inducer and suppressor-effector cells. J Immunol. 1984 Feb;132(2):644–650. [PubMed] [Google Scholar]
  19. Debré P., Kapp J. A., Dorf M. E., Benacerraf B. Genetic control of specific immune suppression. II. H-2-linked dominant genetic control of immune suppression by the random copolymer L-glutamic acid50-L-tyrosine50 (GT). J Exp Med. 1975 Dec 1;142(6):1447–1454. doi: 10.1084/jem.142.6.1447. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Dennison D. K., Rich S. S., Rich R. R. Cellular and antigenic requirements for production of mixed leukocyte reaction suppressor factor. J Immunol. 1981 Nov;127(5):2176–2182. [PubMed] [Google Scholar]
  21. Dorf M. E., Benacerraf B. Suppressor cells and immunoregulation. Annu Rev Immunol. 1984;2:127–157. doi: 10.1146/annurev.iy.02.040184.001015. [DOI] [PubMed] [Google Scholar]
  22. Ebringer A., Deacon N. J., Young C. R. Codominant inheritance in immunogenetic (IR-gene) systems. J Immunogenet. 1976 Dec;3(6):401–409. doi: 10.1111/j.1744-313x.1976.tb00602.x. [DOI] [PubMed] [Google Scholar]
  23. Epstein R., Cohn M. T-cell inhibition of humoral responsiveness. I. Experimental evidence for restriction by the K- and/or D-end of the H-2 gene complex. Cell Immunol. 1978 Aug;39(1):110–124. doi: 10.1016/0008-8749(78)90088-6. [DOI] [PubMed] [Google Scholar]
  24. Fairchild R. L., Moorhead J. W. Soluble factors in tolerance and contact sensitivity to DNFB in mice. VI. Cellular and lymphokine requirements for stimulating suppressor factor production in vitro. J Immunol. 1986 Oct 1;137(7):2125–2131. [PubMed] [Google Scholar]
  25. Fermand J. P., Schmitt C., Brouet J. C. Distribution of class IIDQ antigens on normal and leukemic lymphoid cells. Eur J Immunol. 1985 Dec;15(12):1183–1187. doi: 10.1002/eji.1830151208. [DOI] [PubMed] [Google Scholar]
  26. Flood P. M., Benoist C., Mathis D., Murphy D. B. Altered I-J phenotype in E alpha transgenic mice. Proc Natl Acad Sci U S A. 1986 Nov;83(21):8308–8312. doi: 10.1073/pnas.83.21.8308. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Gasser D. L. Genetic control of the immune response in mice. I. Segregation data and localization to the fifth linkage group of a gene affecting antibody production. J Immunol. 1969 Jul;103(1):66–70. [PubMed] [Google Scholar]
  28. Germain R. N., Quill H. Unexpected expression of a unique mixed-isotype class II MHC molecule by transfected L-cells. Nature. 1986 Mar 6;320(6057):72–75. doi: 10.1038/320072a0. [DOI] [PubMed] [Google Scholar]
  29. Gershon R. K., Kondo K. Infectious immunological tolerance. Immunology. 1971 Dec;21(6):903–914. [PMC free article] [PubMed] [Google Scholar]
  30. Gershon R. K., Lance E. M., Kondo K. Immuno-regulatory role of spleen localizing thymocytes. J Immunol. 1974 Feb;112(2):546–554. [PubMed] [Google Scholar]
  31. Green D. R., Flood P. M., Gershon R. K. Immunoregulatory T-cell pathways. Annu Rev Immunol. 1983;1:439–463. doi: 10.1146/annurev.iy.01.040183.002255. [DOI] [PubMed] [Google Scholar]
  32. Hayglass K. T., Benacerraf B., Sy M. S. T cell development in B cell-deficient mice. V. Stopping anti-mu treatment results in Igh-restricted expansion of the T suppressor cell repertoire concomitant with the development of normal immunoglobulin levels. J Exp Med. 1986 Jul 1;164(1):36–49. doi: 10.1084/jem.164.1.36. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. Heuer J., Degwert J., Kölsch E. Expression of L3T4 molecules on Lyt-2+, class II-restricted antigen-specific T suppressor lymphocytes. Immunogenetics. 1986;24(5):316–323. doi: 10.1007/BF00395537. [DOI] [PubMed] [Google Scholar]
  34. Hirayama K., Matsushita S., Kikuchi I., Iuchi M., Ohta N., Sasazuki T. HLA-DQ is epistatic to HLA-DR in controlling the immune response to schistosomal antigen in humans. Nature. 1987 Jun 4;327(6121):426–430. doi: 10.1038/327426a0. [DOI] [PubMed] [Google Scholar]
  35. Holt P. G., Britten D., Sedgwick J. D. Suppression of IgE responses by antigen inhalation: studies on the role of genetic and environmental factors. Immunology. 1987 Jan;60(1):97–102. [PMC free article] [PubMed] [Google Scholar]
  36. Hood L., Steinmetz M., Malissen B. Genes of the major histocompatibility complex of the mouse. Annu Rev Immunol. 1983;1:529–568. doi: 10.1146/annurev.iy.01.040183.002525. [DOI] [PubMed] [Google Scholar]
  37. Howard J. G., Hale C., Liew F. Y. Immunological regulation of experimental cutaneous leishmaniasis. III. Nature and significance of specific suppression of cell-mediated immunity in mice highly susceptible to Leishmania tropica. J Exp Med. 1980 Sep 1;152(3):594–607. doi: 10.1084/jem.152.3.594. [DOI] [PMC free article] [PubMed] [Google Scholar]
  38. Hutchinson I. V. Suppressor T cells in allogeneic models. Transplantation. 1986 May;41(5):547–555. doi: 10.1097/00007890-198605000-00001. [DOI] [PubMed] [Google Scholar]
  39. Ivanyi J., Sharp K. Control by H-2 genes of murine antibody responses to protein antigens of Mycobacterium tuberculosis. Immunology. 1986 Nov;59(3):329–332. [PMC free article] [PubMed] [Google Scholar]
  40. Jandinski J. J., Li J., Wettstein P. J., Frelinger J. A., Scott D. W. Role of self carriers in the immune response and tolerance. V. Reversal of trinitrophenyl-modified self suppression of the B-cell response by blocking of H-2 antigens. J Exp Med. 1980 Jan 1;151(1):133–143. doi: 10.1084/jem.151.1.133. [DOI] [PMC free article] [PubMed] [Google Scholar]
  41. Jaworski M. A., Colle E., Guttmann R. D. Abnormal immunoregulation in patients with insulin dependent diabetes mellitus and their healthy first degree relatives. Hum Immunol. 1983 May;7(1):25–34. doi: 10.1016/0198-8859(83)90004-6. [DOI] [PubMed] [Google Scholar]
  42. Jensen P. E., Kapp J. A. Genetics of insulin-specific helper and suppressor T cells in nonresponder mice. J Immunol. 1985 Nov;135(5):2990–2995. [PubMed] [Google Scholar]
  43. Jensen P. E., Pierce C. W., Kapp J. A. Regulatory mechanisms in immune responses to heterologous insulins. II. Suppressor T cell activation associated with nonresponsiveness in H-2b mice. J Exp Med. 1984 Oct 1;160(4):1012–1026. doi: 10.1084/jem.160.4.1012. [DOI] [PMC free article] [PubMed] [Google Scholar]
  44. Kappler J. W., Wade T., White J., Kushnir E., Blackman M., Bill J., Roehm N., Marrack P. A T cell receptor V beta segment that imparts reactivity to a class II major histocompatibility complex product. Cell. 1987 Apr 24;49(2):263–271. doi: 10.1016/0092-8674(87)90567-8. [DOI] [PubMed] [Google Scholar]
  45. Klein J., Figueroa F., David C. S. H-2 haplotypes, genes and antigens: second listing. II. The H-2 complex. Immunogenetics. 1983;17(6):553–596. doi: 10.1007/BF00366126. [DOI] [PubMed] [Google Scholar]
  46. Krzych U., Fowler A. V., Sercarz E. E. Repertoires of T cells directed against a large protein antigen, beta-galactosidase. II. Only certain T helper or T suppressor cells are relevant in particular regulatory interactions. J Exp Med. 1985 Jul 1;162(1):311–323. doi: 10.1084/jem.162.1.311. [DOI] [PMC free article] [PubMed] [Google Scholar]
  47. Levich J. D., Weigle W. O., Parks D. E. Long-term suppressor cell lines. II. Suppressor-target interactions. Eur J Immunol. 1984 Dec;14(12):1080–1084. doi: 10.1002/eji.1830141203. [DOI] [PubMed] [Google Scholar]
  48. Margalit H., Spouge J. L., Cornette J. L., Cease K. B., Delisi C., Berzofsky J. A. Prediction of immunodominant helper T cell antigenic sites from the primary sequence. J Immunol. 1987 Apr 1;138(7):2213–2229. [PubMed] [Google Scholar]
  49. Marvel J., Mayer A. CD45R gives immunofluorescence and transduces signals on mouse T cells. Eur J Immunol. 1988 May;18(5):825–828. doi: 10.1002/eji.1830180526. [DOI] [PubMed] [Google Scholar]
  50. Matis L. A., Hedrick S. M., Hannum C., Ultee M. E., Lebwohl D., Margoliash E., Solinger A. M., Lerner E. A., Schwartz R. H. The T lymphocyte response to cytochrome C. III. Relationship of the fine specificity of antigen recognition to major histocompatibility complex genotype. J Immunol. 1982 Jun;128(6):2439–2446. [PubMed] [Google Scholar]
  51. Matsushita S., Muto M., Suemura M., Saito Y., Sasazuki T. HLA-linked nonresponsiveness to Cryptomeria japonica pollen antigen. I. Nonresponsiveness is mediated by antigen-specific suppressor T cell. J Immunol. 1987 Jan 1;138(1):109–115. [PubMed] [Google Scholar]
  52. Milich D. R., Leroux-Roels G. G., Louie R. E., Chisari F. V. Genetic regulation of the immune response to hepatitis B surface antigen (HBsAg). IV. Distinct H-2-linked Ir genes control antibody responses to different HBsAg determinants on the same molecule and map to the I-A and I-C subregions. J Exp Med. 1984 Jan 1;159(1):41–56. doi: 10.1084/jem.159.1.41. [DOI] [PMC free article] [PubMed] [Google Scholar]
  53. Miller K. B., Schwartz R. S. Familial abnormalities of suppressor-cell function in systemic lupus erythematosus. N Engl J Med. 1979 Oct 11;301(15):803–809. doi: 10.1056/NEJM197910113011502. [DOI] [PubMed] [Google Scholar]
  54. Miller K. B., Sepersky R. A., Brown K. M., Goldberg M. J., Kaplan M. M. Genetic abnormalities of immunoregulation in primary biliary cirrhosis. Am J Med. 1983 Jul;75(1):75–80. doi: 10.1016/0002-9343(83)91170-1. [DOI] [PubMed] [Google Scholar]
  55. Miller S. D., Conlon P. J., Sy M. S., Moorhead J. W., Colón S., Grey H. M., Claman H. N. Nature of hapten-modified determinants involved in induction of T cell tolerance and suppressor T cells to NDFB contact sensitivity. J Immunol. 1980 Mar;124(3):1187–1193. [PubMed] [Google Scholar]
  56. Miller S. D. Suppressor T cell circuits in contact sensitivity. II. Induction and characterization of an efferent-acting, antigen-specific, H-2-restricted, monoclonal T cell hybrid-derived suppressor factor specific for DNFB contact hypersensitivity. J Immunol. 1984 Dec;133(6):3112–3120. [PubMed] [Google Scholar]
  57. Modlin R. L., Kato H., Mehra V., Nelson E. E., Fan X. D., Rea T. H., Pattengale P. K., Bloom B. R. Genetically restricted suppressor T-cell clones derived from lepromatous leprosy lesions. 1986 Jul 31-Aug 6Nature. 322(6078):459–461. doi: 10.1038/322459a0. [DOI] [PubMed] [Google Scholar]
  58. Mohagheghpour N., Damle N. K., Takada S., Engleman E. G. Generation of antigen receptor-specific suppressor T cell clones in man. J Exp Med. 1986 Sep 1;164(3):950–955. doi: 10.1084/jem.164.3.950. [DOI] [PMC free article] [PubMed] [Google Scholar]
  59. Morimoto C., Letvin N. L., Distaso J. A., Brown H. M., Schlossman S. F. The cellular basis for the induction of antigen-specific T8 suppressor cells. Eur J Immunol. 1986 Feb;16(2):198–204. doi: 10.1002/eji.1830160216. [DOI] [PubMed] [Google Scholar]
  60. Morimoto C., Letvin N. L., Rudd C. E., Hagan M., Takeuchi T., Schlossman S. F. The role of the 2H4 molecule in the generation of suppressor function in Con A-activated T cells. J Immunol. 1986 Nov 15;137(10):3247–3253. [PubMed] [Google Scholar]
  61. Mosmann T. R., Cherwinski H., Bond M. W., Giedlin M. A., Coffman R. L. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol. 1986 Apr 1;136(7):2348–2357. [PubMed] [Google Scholar]
  62. Mowat A. M., Lamont A. G., Bruce M. G. A genetically determined lack of oral tolerance to ovalbumin is due to failure of the immune system to respond to intestinally derived tolerogen. Eur J Immunol. 1987 Nov;17(11):1673–1676. doi: 10.1002/eji.1830171126. [DOI] [PubMed] [Google Scholar]
  63. Muckerheide A., Pesce A. J., Michael J. G. Immunosuppressive properties of a peptic fragment of BSA. J Immunol. 1977 Oct;119(4):1340–1345. [PubMed] [Google Scholar]
  64. Murphy D. B. Commentary on the genetic basis for control of I-J determinants. J Immunol. 1985 Sep;135(3):1543–1547. [PubMed] [Google Scholar]
  65. Murphy D. B., Herzenberg L. A., Okumura K., Herzenberg L. A., McDevitt H. O. A new I subregion (I-J) marked by a locus (Ia-4) controlling surface determinants on suppressor T lymphocytes. J Exp Med. 1976 Sep 1;144(3):699–712. doi: 10.1084/jem.144.3.699. [DOI] [PMC free article] [PubMed] [Google Scholar]
  66. Nakayama T., Kubo R. T., Kubo M., Fujisawa I., Kishimoto H., Asano Y., Tada T., Asao Y. Epitopes associated with major histocompatibility complex (MHC) restriction site of T cells. IV. I-J epitopes on MHC-restricted cloned T cells. Eur J Immunol. 1988 May;18(5):761–765. doi: 10.1002/eji.1830180516. [DOI] [PubMed] [Google Scholar]
  67. Nishimoto H., Kikutani H., Yamamura K., Kishimoto T. Prevention of autoimmune insulitis by expression of I-E molecules in NOD mice. 1987 Jul 30-Aug 5Nature. 328(6129):432–434. doi: 10.1038/328432a0. [DOI] [PubMed] [Google Scholar]
  68. Nouri-Aria K. T., Donaldson P. T., Hegarty J. E., Eddleston A. L., Williams R. HLA A1-B8-DR3 and suppressor cell function in first-degree relatives of patients with autoimmune chronic active hepatitis. J Hepatol. 1985;1(3):235–241. doi: 10.1016/s0168-8278(85)80051-9. [DOI] [PubMed] [Google Scholar]
  69. O'Brien C. J., Vento S., Donaldson P. T., McSorley C. G., McFarlane I. G., Williams R., Eddleston A. L. Cell-mediated immunity and suppressor-T-cell defects to liver-derived antigens in families of patients with autoimmune chronic active hepatitis. Lancet. 1986 Feb 15;1(8477):350–353. doi: 10.1016/s0140-6736(86)92318-4. [DOI] [PubMed] [Google Scholar]
  70. Oliveira D. B., Blackwell N., Virchis A. E., Axelrod R. A. T helper and T suppressor cells are restricted by the A and E molecules, respectively, in the F antigen system. Immunogenetics. 1985;22(2):169–175. doi: 10.1007/BF00563514. [DOI] [PubMed] [Google Scholar]
  71. Oliveira D. B., Nardi N. B. Immune suppression genes control the anti-F antigen response in F1 hybrids and recombinant inbred sets of mice. Immunogenetics. 1987;26(6):359–365. doi: 10.1007/BF00343705. [DOI] [PubMed] [Google Scholar]
  72. Ottenhoff T. H., Elferink D. G., Klatser P. R., de Vries R. R. Cloned suppressor T cells from a lepromatous leprosy patient suppress Mycobacterium leprae reactive helper T cells. 1986 Jul 31-Aug 6Nature. 322(6078):462–464. doi: 10.1038/322462a0. [DOI] [PubMed] [Google Scholar]
  73. Ottenhoff T. H., Gonzalez N. M., de Vries R. R., Convit J., van Rood J. J. Association of HLA specificity LB-E12 (MB1, DC1, MT1) with lepromatous leprosy in a Venezuelan population. Tissue Antigens. 1984 Jul;24(1):25–29. doi: 10.1111/j.1399-0039.1984.tb00393.x. [DOI] [PubMed] [Google Scholar]
  74. Pang T., Blanden R. V. Regulation of the T-cell response to ectromelia virus infection. I. Feedback suppression by effector T cells. J Exp Med. 1976 Mar 1;143(3):469–481. doi: 10.1084/jem.143.3.469. [DOI] [PMC free article] [PubMed] [Google Scholar]
  75. Perry L. L., Greene M. I. Conversion of immunity to suppression by in vivo administration of I-A subregion-specific antibodies. J Exp Med. 1982 Aug 1;156(2):480–491. doi: 10.1084/jem.156.2.480. [DOI] [PMC free article] [PubMed] [Google Scholar]
  76. Pierce C. W., Kapp J. A. Suppressor T-cell activity in responder X nonresponder (C57BL/10 X DBA/1)F1 spleen cells responsive to L-glutamic acid60-L-alanine30-L-tyrosine10. J Exp Med. 1978 Nov 1;148(5):1282–1291. doi: 10.1084/jem.148.5.1282. [DOI] [PMC free article] [PubMed] [Google Scholar]
  77. Powers G. D., Miller R. A. Heterogeneity among T helper cells. Interleukin 2 secretion and help for immunoglobulin secretion. J Immunol. 1987 Oct 15;139(8):2567–2572. [PubMed] [Google Scholar]
  78. Ptak W., Rozycka D., Askenase P. W., Gershon R. K. Role of antigen-presenting cells in the development and persistence of contact hypersensitivity. J Exp Med. 1980 Feb 1;151(2):362–375. doi: 10.1084/jem.151.2.362. [DOI] [PMC free article] [PubMed] [Google Scholar]
  79. Rich S. S., Rich R. R. Regulatory mechanisms in cell-mediated immune responses. I. Regulation of mixed lymphocyte reactions by alloantigen-activated thymus-derived lymphocytes. J Exp Med. 1974 Dec 1;140(6):1588–1603. doi: 10.1084/jem.140.6.1588. [DOI] [PMC free article] [PubMed] [Google Scholar]
  80. Rich S., Carpino M. R., Arhelger C. Suppressor T cell growth and differentiation. Identification of a cofactor required for suppressor T cell function and distinct from interleukin 2. J Exp Med. 1984 May 1;159(5):1473–1490. doi: 10.1084/jem.159.5.1473. [DOI] [PMC free article] [PubMed] [Google Scholar]
  81. Rothbard J. B., Townsend A., Edwards M., Taylor W. Pattern recognition among T-cell epitopes. Haematol Blood Transfus. 1987;31:324–331. doi: 10.1007/978-3-642-72624-8_68. [DOI] [PubMed] [Google Scholar]
  82. Sadegh-Nasseri S., Dessi V., Sercarz E. E. Selective reversal of H-2-linked genetic unresponsiveness to lysozymes. II. Alteration in the T helper/T suppressor balance, owing to gene(s) linked to Ir-2, leads to responsiveness in BALB.B. Eur J Immunol. 1986 May;16(5):486–492. doi: 10.1002/eji.1830160504. [DOI] [PubMed] [Google Scholar]
  83. Schrader J. W. Nature of the T-cell receptor. Both the T-cell receptor and antigen-specific T-cell-derived factors are coded for by V genes but express anti-self idiotypes indirectly determined by major histocompatibility complex genes. Scand J Immunol. 1979;10(5):387–393. doi: 10.1111/j.1365-3083.1979.tb01365.x. [DOI] [PubMed] [Google Scholar]
  84. Schwartz M., Waltenbaugh C., Dorf M., Cesla R., Sela M., Benacerraf B. Determinants of antigenic molecules responsible for genetically controlled regulation of immune responses. Proc Natl Acad Sci U S A. 1976 Aug;73(8):2862–2866. doi: 10.1073/pnas.73.8.2862. [DOI] [PMC free article] [PubMed] [Google Scholar]
  85. Schwartz R. H. T-lymphocyte recognition of antigen in association with gene products of the major histocompatibility complex. Annu Rev Immunol. 1985;3:237–261. doi: 10.1146/annurev.iy.03.040185.001321. [DOI] [PubMed] [Google Scholar]
  86. Seman M., Zilberfarb V. Complementation between a gene of the I-E subregion and a non-H-2 gene in the class-specific suppression of IgG2a antibody to sheep erythrocytes. Immunogenetics. 1981;12(1-2):89–99. doi: 10.1007/BF01561653. [DOI] [PubMed] [Google Scholar]
  87. Servis C., Seckler R., Nagy Z. A., Klein J. Two adjacent epitopes on a synthetic dodecapeptide induce lactate dehydrogenase B-specific helper and suppressor T cells. Proc R Soc Lond B Biol Sci. 1986 Sep 22;228(1253):461–470. doi: 10.1098/rspb.1986.0063. [DOI] [PubMed] [Google Scholar]
  88. Sprent J., Alpert B. Role of the H-2 complex in induction of T helper cells in vivo. II Negative selection of discrete subgroups of T cells restricted by I-A and I-A/E determinants. J Exp Med. 1981 Apr 1;153(4):823–831. doi: 10.1084/jem.153.4.823. [DOI] [PMC free article] [PubMed] [Google Scholar]
  89. Starren J. B., Davie J. M. Ir gene-controlled response to haptenated hen ovomucoid: isotypic specificity and dominant nonresponsiveness. Cell Immunol. 1987 Jan;104(1):59–70. doi: 10.1016/0008-8749(87)90006-2. [DOI] [PubMed] [Google Scholar]
  90. Sugimura K., Yamasaki N., Matsuura M., Watanabe T. Antigen-specific T cell suppressor factor (TsF): isolation of a cDNA clone encoding for a functional polypeptide chain of phosphorylcholine-specific TsF. Eur J Immunol. 1985 Sep;15(9):873–880. doi: 10.1002/eji.1830150903. [DOI] [PubMed] [Google Scholar]
  91. Sumida T., Sado T., Kojima M., Ono K., Kamisaku H., Taniguchi M. I-J as an idiotype of the recognition component of antigen-specific suppressor T-cell factor. Nature. 1985 Aug 22;316(6030):738–741. doi: 10.1038/316738a0. [DOI] [PubMed] [Google Scholar]
  92. Svejgaard A., Platz P., Ryder L. P. HLA and disease 1982--a survey. Immunol Rev. 1983;70:193–218. doi: 10.1111/j.1600-065x.1983.tb00715.x. [DOI] [PubMed] [Google Scholar]
  93. Swain S. L., Dutton R. W. Negative allogeneic effects in vitro. II. Mapping of histocompatibility differences leading to allosuppression. J Immunol. 1977 Sep;119(3):1179–1186. [PubMed] [Google Scholar]
  94. Swanborg R. H. Antigen-induced inhibition of experimental allergic encephalomyelitis. III. Localization of an inhibitory site distinct from the major encephalitogenic determinant of myelin basic protein. J Immunol. 1975 Jan;114(1 Pt 1):191–194. [PubMed] [Google Scholar]
  95. Tada T., Taniguchi M., David C. S. Properties of the antigen-specific suppressive T-cell factor in the regulation of antibody response of the mouse. IV. Special subregion assignment of the gene(s) that codes for the suppressive T-cell factor in the H-2 histocompatibility complex. J Exp Med. 1976 Sep 1;144(3):713–725. doi: 10.1084/jem.144.3.713. [DOI] [PMC free article] [PubMed] [Google Scholar]
  96. Tite J. P., Janeway C. A., Jr Cloned helper T cells can kill B lymphoma cells in the presence of specific antigen: Ia restriction and cognate vs. noncognate interactions in cytolysis. Eur J Immunol. 1984 Oct;14(10):878–886. doi: 10.1002/eji.1830141004. [DOI] [PubMed] [Google Scholar]
  97. Todd J. A., Bell J. I., McDevitt H. O. HLA-DQ beta gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus. Nature. 1987 Oct 15;329(6140):599–604. doi: 10.1038/329599a0. [DOI] [PubMed] [Google Scholar]
  98. Uhteg L. C., Salomon D. R., Cohen D. J., Cramer D. V., Carpenter C. B. Characterization of the Ia antigens involved in suppressor T cell generation in the rat. Immunogenetics. 1987;26(3):138–142. doi: 10.1007/BF00365902. [DOI] [PubMed] [Google Scholar]
  99. Uracz W., Asano Y., Abe R., Tada T. I-J epitopes are adaptively acquired by T cells differentiated in the chimaeric condition. Nature. 1985 Aug 22;316(6030):741–743. doi: 10.1038/316741a0. [DOI] [PubMed] [Google Scholar]
  100. Waltenbaugh C., Sun L., Lei H. Y. Regulation of immune responses by I-J gene products. VI. Recognition of I-E molecules by I-J-bearing suppressor factors. J Exp Med. 1986 Apr 1;163(4):797–811. doi: 10.1084/jem.163.4.797. [DOI] [PMC free article] [PubMed] [Google Scholar]
  101. Weaver M., Singhai R., Sikora L., Levy J. G. Identification of an idiotypic marker of a major regulatory T cell of the immune response in B10.BR mice to ferredoxin. The relationship of idiotypic regulation to conventional hapten-carrier effects. J Exp Med. 1983 Jan 1;157(1):285–300. doi: 10.1084/jem.157.1.285. [DOI] [PMC free article] [PubMed] [Google Scholar]
  102. Wicker L. S., Hildemann W. H. Two distinct high immune response phenotypes are both controlled by H-2 genes mapping K or I-A. Immunogenetics. 1981;12(3-4):253–265. doi: 10.1007/BF01561668. [DOI] [PubMed] [Google Scholar]
  103. Wicker L. S., Katz M., Sercarz E. E., Miller A. Immunodominant protein epitopes. I. Induction of suppression to hen egg white lysozyme is obliterated by removal of the first three N-terminal amino acids. Eur J Immunol. 1984 May;14(5):442–447. doi: 10.1002/eji.1830140511. [DOI] [PubMed] [Google Scholar]
  104. Yamauchi K., Murphy D., Cantor H., Gershon R. K. Analysis of antigen-specific, Ig-restricted cell-free material made by I-J+ Ly-1 cells (Ly-1 TsiF) that induces Ly-2+ cells to express suppressive activity. Eur J Immunol. 1981 Nov;11(11):905–912. doi: 10.1002/eji.1830111110. [DOI] [PubMed] [Google Scholar]

Articles from Clinical and Experimental Immunology are provided here courtesy of British Society for Immunology

RESOURCES