Abstract
The regional lymph nodes of mice show increased IL-2 activated killer (LAK) activity following immunization with the contact sensitizing agents, 'oxazolone' and picryl chloride. This is best elicited with 500 mu/ml human recombinant IL-2 and can be demonstrated with both YAC-1 and K562 targets. There is also a lesser increase in NK activity.
Full text
PDF




Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Asherson G. L., Colizzi V., Watkins M. C. Immunogenic cells in the regional lymph nodes after painting with the contact sensitizers picryl chloride and oxazolone: evidence for the presence of IgM antibody on their surface. Immunology. 1983 Mar;48(3):561–569. [PMC free article] [PubMed] [Google Scholar]
- Asherson G. L., Ferluga J. Contact sensitivity in the mouse. X. Non-specific cytotoxicity of T blasts in the draining lymph nodes. Immunology. 1973 Sep;25(3):471–483. [PMC free article] [PubMed] [Google Scholar]
- Asherson G. L., Zembala M., Thomas W. R., Perera M. A. Suppressor cells and the handling of antigen. Immunol Rev. 1980;50:3–45. doi: 10.1111/j.1600-065x.1980.tb00306.x. [DOI] [PubMed] [Google Scholar]
- Colizzi V., Asherson G. L., James B. M., Malkovsky M. T helper factor in contact sensitivity: antigen-specific I-A+ helper factor is made by an Lyt-1+2-, I-A+, I-J- T cell. Immunology. 1984 Jun;52(2):261–267. [PMC free article] [PubMed] [Google Scholar]
- Goto M., Zvaifler N. J. Characterization of the precursors of the NK-like cytotoxic cells generated in the autologous mixed leukocyte reaction and by interleukin 2 activation. J Clin Lab Immunol. 1986 Mar;19(3):105–111. [PubMed] [Google Scholar]
- Guillén F. J., Ferrara J., Hancock W. W., Messadi D., Fonferko E., Burakoff S. J., Murphy G. F. Acute cutaneous graft-versus-host disease to minor histocompatibility antigens in a murine model. Evidence that large granular lymphocytes are effector cells in the immune response. Lab Invest. 1986 Jul;55(1):35–42. [PubMed] [Google Scholar]
- Lattime E. C., Pecoraro G. A., Stutman O. The activity of natural cytotoxic cells is augmented by interleukin 2 and interleukin 3. J Exp Med. 1983 Mar 1;157(3):1070–1075. doi: 10.1084/jem.157.3.1070. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Levi J. A., Wiernik P. H. Management of mycosis fungoides--current status and future prospects. Medicine (Baltimore) 1975 Jan;54(1):73–88. doi: 10.1097/00005792-197501000-00004. [DOI] [PubMed] [Google Scholar]
- Levis W. R., Kraemer K. H., Klingler W. G., Peck G. L., Terry W. D. Topical immunotherapy of basal cell carcinomas with dinitrochlorobenzene. Cancer Res. 1973 Nov;33(11):3036–3042. [PubMed] [Google Scholar]
- Malkovský M., Brenner M. K., Hunt R., Rastan S., Doré C., Brown S., North M. E., Asherson G. L., Prentice H. G., Medawar P. B. T-cell depletion of allogeneic bone marrow prevents acceleration of graft-versus-host disease induced by exogenous interleukin 2. Cell Immunol. 1986 Dec;103(2):476–480. doi: 10.1016/0008-8749(86)90108-5. [DOI] [PubMed] [Google Scholar]
- Malkovský M., Medawar P. B., Thatcher D. R., Toy J., Hunt R., Rayfield L. S., Doré C. Acquired immunological tolerance of foreign cells is impaired by recombinant interleukin 2 or vitamin A acetate. Proc Natl Acad Sci U S A. 1985 Jan;82(2):536–538. doi: 10.1073/pnas.82.2.536. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mulé J. J., Ettinghausen S. E., Spiess P. J., Shu S., Rosenberg S. A. Antitumor efficacy of lymphokine-activated killer cells and recombinant interleukin-2 in vivo: survival benefit and mechanisms of tumor escape in mice undergoing immunotherapy. Cancer Res. 1986 Feb;46(2):676–683. [PubMed] [Google Scholar]
- Shah P. D., Gilbertson S. M., Rowley D. A. Dendritic cells that have interacted with antigen are targets for natural killer cells. J Exp Med. 1985 Aug 1;162(2):625–636. doi: 10.1084/jem.162.2.625. [DOI] [PMC free article] [PubMed] [Google Scholar]