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. 1986 Jul;65(1):182–189.

Interleukin 2 enhances natural killing of varicella-zoster virus-infected targets.

M Ito, S Bandyopadhyay, M Matsumoto-Kobayashi, S C Clark, D Miller, S E Starr
PMCID: PMC1542273  PMID: 3098472

Abstract

Preincubation of peripheral blood non-adherent mononuclear cells with purified or recombinant interleukin 2 (IL-2) significantly enhanced natural killer (NK) activity against uninfected and varicella-zoster virus (VZV)-infected targets, while antibody-dependent cellular cytotoxicity (ADCC) against VZV-infected targets was not increased. Preincubation of effector cells with IL-2 had no effect on conjugate formation, but lysis of both targets was increased in single cell assays. IL-2-enhanced NK against VZV-infected targets was independent of gamma-interferon (gamma-IFN) production.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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