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. 1986 Aug;65(2):354–362.

Expression of Tac antigen in B cell lymphomas.

G Laurent, T Al Saati, D Olive, J C Laurent, P Poncelet, G Delsol
PMCID: PMC1542297  PMID: 3024885

Abstract

In a series of 55 cases of B cell derived non-Hodgkin's lymphoma the reactivity of two distinct anti-Tac monoclonal antibodies was examined using a sensitive immunoperoxidase technique on cryostat sections. Eighteen out of the thirty-five cases of B cell lymphomas of low or intermediate grade of malignancy were found to be reactive while six out of 20 cases of high-grade malignancy lymphomas showed a positive immunostaining. No correlation was found between anti-Tac reactivity and surface immunoglobulin phenotype, T65 antigen, or calla expression. These findings showed that IL2 receptor expression is not restricted to activated T cells, and raise the question of the possible role of IL2 in the regulation of malignant B cell clone expansion.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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