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. 1986 Aug;65(2):427–433.

Impaired IgG2 anti-pneumococcal antibody responses in patients with recurrent infection and normal IgG2 levels but no IgA.

P J Lane, I C MacLennan
PMCID: PMC1542305  PMID: 3791703

Abstract

Combined IgA and IgG2 deficiency is well recognized as being associated with an increased susceptibility to pyogenic infection. A similar syndrome is described in four patients with IgA deficiency who were unable to produce IgG2 subclass antibodies to pneumococcal capsular polysaccharides but whose total IgG2 levels were in the normal or near normal range. This emphasizes the importance of measuring class and subclass responses to different types of antigen when investigating patients with suspected deficiencies of antibody production.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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