Skip to main content
NCBI home page
Clinical and Experimental Immunology logoLink to Clinical and Experimental Immunology
. 1986 May;64(2):323–329.

Association of circulating immune complexes containing bovine proteins and graft-versus-host disease.

C Cunningham-Rundles, R O'Reilly
PMCID: PMC1542328  PMID: 3527503

Abstract

Chronic graft-versus-host disease (GVHD) is a complex immunological disease which can appear in up to 30% of survivors of allogeneic bone marrow transplantation. Target organs include skin, mucous membranes and liver; eventual mucosal defects, specifically involving secretory IgA, have been observed. In these studies we show that transplant recipients who develop GVHD are more likely to have higher serum antibody titres to bovine casein and circulating immune complexes containing casein than patients who do not develop this complication. The stage of GVHD may be related to the level of antibody to casein. The biological role of immune complexes in relationship to the evolution of this disease is unknown.

Full text

PDF
323

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Atkinson K., Hansen J. A., Storb R., Goehle S., Goldstein G., Thomas E. D. T-cell subpopulations identified by monoclonal antibodies after human marrow transplantation. I. Helper-inducer and cytotoxic-suppressor subsets. Blood. 1982 Jun;59(6):1292–1298. [PubMed] [Google Scholar]
  2. Cochrane C. G., Koffler D. Immune complex disease in experimental animals and man. Adv Immunol. 1973;16(0):185–264. doi: 10.1016/s0065-2776(08)60298-9. [DOI] [PubMed] [Google Scholar]
  3. Cunningham-Rundles C., Brandeis W. E., Good R. A., Day N. K. Milk precipitins, circulating immune complexes, and IgA deficiency. Proc Natl Acad Sci U S A. 1978 Jul;75(7):3387–3389. doi: 10.1073/pnas.75.7.3387. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Cunningham-Rundles C., Brandeis W. E., Safai B., O'Reilly R., Day N. K., Good R. A. Selective IgA deficiency and circulating immune complexes containing bovine proteins in a child with chronic graft versus host disease. Am J Med. 1979 Nov;67(5):883–890. doi: 10.1016/0002-9343(79)90749-6. [DOI] [PubMed] [Google Scholar]
  5. Cunningham-Rundles C. The identification of specific antigens in circulating immune complexes by an enzyme-linked immunosorbent assay: detection of bovine kappa-casein IgG complexes in human sera. Eur J Immunol. 1981 Jun;11(6):504–509. doi: 10.1002/eji.1830110612. [DOI] [PubMed] [Google Scholar]
  6. Friedrich W., O'Reilly R. J., Koziner B., Gebhard D. F., Jr, Good R. A., Evans R. L. T-lymphocyte reconstitution in recipients of bone marrow transplants with and without GVHD: imbalances of T-cell subpopulations having unique regulatory and cognitive functions. Blood. 1982 Apr;59(4):696–701. [PubMed] [Google Scholar]
  7. Graze P. R., Gale R. P. Chronic graft versus host disease: a syndrome of disordered immunity. Am J Med. 1979 Apr;66(4):611–620. doi: 10.1016/0002-9343(79)91171-9. [DOI] [PubMed] [Google Scholar]
  8. Izutsu K. T., Sullivan K. M., Schubert M. M., Truelove E. L., Shulman H. M., Sale G. E., Morton T. H., Rice J. C., Witherspoon R. P., Storb R. Disordered salivary immunoglobulin secretion and sodium transport in human chronic graft-versus-host disease. Transplantation. 1983 May;35(5):441–446. doi: 10.1097/00007890-198305000-00010. [DOI] [PubMed] [Google Scholar]
  9. Manca F., Bacigalupo A., Van Lint M. T., Trovatello G., Cantarella S., Frassoni F., Marmont A., Celada F. Circulating immune complexes in allogeneic marrow graft recipients. Transplantation. 1984 Oct;38(4):428–430. doi: 10.1097/00007890-198410000-00022. [DOI] [PubMed] [Google Scholar]
  10. O'Reilly R. J. Allogenic bone marrow transplantation: current status and future directions. Blood. 1983 Nov;62(5):941–964. [PubMed] [Google Scholar]
  11. Pereira A. B., Theofilopoulos A. N., Dixon F. J. Detection and partial characterization of circulating immune complexes with solid-phase anti-C3. J Immunol. 1980 Aug;125(2):763–770. [PubMed] [Google Scholar]
  12. Shulman H. M., Sale G. E., Lerner K. G., Barker E. A., Weiden P. L., Sullivan K., Gallucci B., Thomas E. D., Storb R. Chronic cutaneous graft-versus-host disease in man. Am J Pathol. 1978 Jun;91(3):545–570. [PMC free article] [PubMed] [Google Scholar]
  13. Sullivan K. M., Parkman R. The pathophysiology and treatment of graft-versus-host disease. Clin Haematol. 1983 Oct;12(3):775–789. doi: 10.1016/s0308-2261(83)80010-1. [DOI] [PubMed] [Google Scholar]
  14. Tsoi M. S., Storb R., Jones E., Weiden P. L., Shulman H., Witherspoon R., Atkinson K., Thomas E. D. Deposition of IgM and complement at the dermoepidermal junction in acute and chronic cutaneous graft-vs-host disease in man. J Immunol. 1978 May;120(5):1485–1492. [PubMed] [Google Scholar]

Articles from Clinical and Experimental Immunology are provided here courtesy of British Society for Immunology

RESOURCES