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. 1986 Dec;66(3):640–647.

An investigation into the effect of the IgG antibody system on the susceptibility of IgA-deficient patients to respiratory tract infections.

M A French, G Harrison
PMCID: PMC1542474  PMID: 3568451

Abstract

Serum IgG subclass concentrations and IgG-tetanus toxoid antibody (IgG-TTab) responses were measured in IgA-deficient patients with severe respiratory tract infections (n = 11), mild respiratory tract infections (n = 5) or no increased susceptibility to respiratory tract infections (n = 15). The severe infection group had lower IgG2 concentrations than the patients without infections (P less than 0.02) and was the only group with IgG2-deficient patients (36%). The number of sera in which IgG4 was not detected was higher in patients with severe infections than in both normal controls (45% vs 10%, P less than 0.01) and the other IgA-deficient patients (45% vs 20%), in part explained by a strong association with IgG2 deficiency. Subnormal IgG-TTab responses were demonstrated in 45% of patients with severe infections but in only one patient from each of the other two groups. Five patients with IgG2 deficiency and/or subnormal IgG-TTab responses were treated with gammaglobulin and apparently improved. There was a high serum concentration of IgG1 in 35% and IgG3 in 19% of the 31 patients, predominantly in those without severe infections. Thus a proportion of IgA-deficient patients have additional defects of IgG; IgG1 and IgG3 antibody responses may compensate for the IgA deficiency in asymptomatic patients.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ammann A. J., Hong R. Selective IgA deficiency: presentation of 30 cases and a review of the literature. Medicine (Baltimore) 1971 May;50(3):223–236. [PubMed] [Google Scholar]
  2. Björkander J., Bake B., Oxelius V. A., Hanson L. A. Impaired lung function in patients with IgA deficiency and low levels of IgG2 or IgG3. N Engl J Med. 1985 Sep 19;313(12):720–724. doi: 10.1056/NEJM198509193131203. [DOI] [PubMed] [Google Scholar]
  3. Cassidy J. T., Oldham G., Platts-Mills T. A. Functional assessment of a B cell defect in patients with selective IgA deficiency. Clin Exp Immunol. 1979 Feb;35(2):296–305. [PMC free article] [PubMed] [Google Scholar]
  4. D'Amelio R., LeMoli S., Rossi P., Aiuti F. Neutrophil chemotaxis defect in IgA deficiency evaluated by migration agarose method. Scand J Immunol. 1980;11(5):471–477. doi: 10.1111/j.1365-3083.1980.tb00015.x. [DOI] [PubMed] [Google Scholar]
  5. De Graeff P. A., The T. H., van Munster P. J., Out T. A., Vossen J. M., Zegers B. J. The primary immune response in patients with selective IgA deficiency. Clin Exp Immunol. 1983 Dec;54(3):778–784. [PMC free article] [PubMed] [Google Scholar]
  6. De la Concha E. G., Subiza J. L., Fontán G., Pascual-Salcedo D., Sequí J., Bootello A. Disorders of regulatory T cells in patients with selective IgA deficiency and its relationship to associated autoimmune phenomena. Clin Exp Immunol. 1982 Aug;49(2):410–418. [PMC free article] [PubMed] [Google Scholar]
  7. French M. A., Harrison G. Serum IgG subclass concentrations in healthy adults: a study using monoclonal antisera. Clin Exp Immunol. 1984 May;56(2):473–475. [PMC free article] [PubMed] [Google Scholar]
  8. French M. A., Harrison G. Systemic antibody deficiency in patients without serum immunoglobulin deficiency or with selective IgA deficiency. Clin Exp Immunol. 1984 Apr;56(1):18–22. [PMC free article] [PubMed] [Google Scholar]
  9. Heiner D. C. Significance of immunoglobulin G subclasses. Am J Med. 1984 Mar 30;76(3A):1–6. doi: 10.1016/0002-9343(84)90313-9. [DOI] [PubMed] [Google Scholar]
  10. Koistinen J., Heikkilä M., Leikola J. Gammaglobulin treatment and anti-IgA antibodies in IgA-deficient patients. Br Med J. 1978 Sep 30;2(6142):923–924. doi: 10.1136/bmj.2.6142.923. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Koistinen J. Selective IgA deficiency in blood donors. Vox Sang. 1975;29(3):192–202. doi: 10.1111/j.1423-0410.1975.tb00494.x. [DOI] [PubMed] [Google Scholar]
  12. Melamed I., Zakuth V., Kark J. O., Spirer Z. The immune system in isolated IgA deficiency. J Clin Lab Immunol. 1985 Aug;17(4):163–166. [PubMed] [Google Scholar]
  13. Milford Ward A., White P. A., French M. A., Harrison G. A calibration material for IgG subclass assay. J Clin Lab Immunol. 1984 Aug;14(4):209–210. [PubMed] [Google Scholar]
  14. Ogra P. L., Coppola P. R., MacGillivray M. H., Dzierba J. L. Mechanism of mucosal immunity to viral infections in gammaA immunoglobulin-deficiency syndromes. Proc Soc Exp Biol Med. 1974 Mar;145(3):811–816. doi: 10.3181/00379727-145-37900. [DOI] [PubMed] [Google Scholar]
  15. Oxelius V. A., Laurell A. B., Lindquist B., Golebiowska H., Axelsson U., Björkander J., Hanson L. A. IgG subclasses in selective IgA deficiency: importance of IgG2-IgA deficiency. N Engl J Med. 1981 Jun 11;304(24):1476–1477. doi: 10.1056/NEJM198106113042408. [DOI] [PubMed] [Google Scholar]
  16. Plebani A., Mira E., Mevio E., Monafo V., Notarangelo L. D., Avanzini A., Ugazio A. G. IgM and IgD concentrations in the serum and secretions of children with selective IgA deficiency. Clin Exp Immunol. 1983 Sep;53(3):689–696. [PMC free article] [PubMed] [Google Scholar]
  17. Polmar S. H., Waldmann T. A., Balestra S. T., Jost M. C., Terry W. D. Immunoglobulin E in immunologic deficiency diseases. I. Relation of IgE and IgA to respiratory tract disease in isolated IgE deficiency, IgA deficiency, and ataxia telangiectasia. J Clin Invest. 1972 Feb;51(2):326–330. doi: 10.1172/JCI106817. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Stanley P. J., Corbo G., Cole P. J. Serum IgG subclasses in chronic and recurrent respiratory infections. Clin Exp Immunol. 1984 Dec;58(3):703–708. [PMC free article] [PubMed] [Google Scholar]
  19. Ugazio A. G., Out T. A., Plebani A., Duse M., Monafo V., Nespoli L., Burgio G. R. Recurrent infections in children with "selective" IgA deficiency: association with IgG2 and IgG4 deficiency. Birth Defects Orig Artic Ser. 1983;19(3):169–171. [PubMed] [Google Scholar]
  20. Umetsu D. T., Ambrosino D. M., Quinti I., Siber G. R., Geha R. S. Recurrent sinopulmonary infection and impaired antibody response to bacterial capsular polysaccharide antigen in children with selective IgG-subclass deficiency. N Engl J Med. 1985 Nov 14;313(20):1247–1251. doi: 10.1056/NEJM198511143132002. [DOI] [PubMed] [Google Scholar]
  21. van der Giessen M., Reerink-Brongers E. E., Veen T. A. Quantitation of Ig classes and IgG subclasses in sera of patients with a variety of immunoglobulin deficiencies and their relatives. Clin Immunol Immunopathol. 1976 May;5(3):388–398. doi: 10.1016/0090-1229(76)90048-9. [DOI] [PubMed] [Google Scholar]

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