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. 1986 Sep;65(3):582–588.

Appearance of spontaneously Ig secreting B cells in human peripheral blood after surgery.

F Di Padova, C Di Padova, P Rovagnati, R Tritapepe
PMCID: PMC1542487  PMID: 3490939

Abstract

Lymphoblastoid B cells, spontaneously secreting specific antibodies of IgG and IgA classes, are constantly detected after in-vivo immunization and represent a sensitive marker of a recent antigenic exposure. In this study we demonstrate that surgical trauma is followed, at a well-defined time after surgery, by the appearance of circulating lymphoblastoid B cells spontaneously secreting IgG and IgA. The kinetics and the functional behaviour of this B cell subset are identical to those of lymphoblastoid B cells observed after in-vivo immunization. Our data indicate that surgical trauma activates a humoral immune response. Antigens released by traumatized tissues or encountered through breaches in skin or mucous membranes might initiate the reaction.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Akiyoshi T., Koba F., Arinaga S., Miyazaki S., Wada T., Tsuji H. Impaired production of interleukin-2 after surgery. Clin Exp Immunol. 1985 Jan;59(1):45–49. [PMC free article] [PubMed] [Google Scholar]
  2. Alexander J. W., Hegg M., Altemeier W. A. Neutrophil function in selected surgical disorders. Ann Surg. 1968 Sep;168(3):447–458. doi: 10.1097/00000658-196809000-00012. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Constantian M. B., Menzoian J. O., Nimberg R. B., Schmid K., Mannick J. A. Association of a circulating immunosuppressive polypeptide with operative and accidental trauma. Ann Surg. 1977 Jan;185(1):73–79. doi: 10.1097/00000658-197701000-00012. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Cooper A. J., Irvine J. M., Turnbull A. R. Depression of immunological responses due to surgery. A model in the guinea-pig. Immunology. 1974 Sep;27(3):393–399. [PMC free article] [PubMed] [Google Scholar]
  5. Cupps T. R., Goldsmith P. K., Volkman D. J., Gerin J. L., Purcell R. H., Fauci A. S. Activation of human peripheral blood B cells following immunization with hepatitis B surface antigen vaccine. Cell Immunol. 1984 Jun;86(1):145–154. doi: 10.1016/0008-8749(84)90367-8. [DOI] [PubMed] [Google Scholar]
  6. Di Padova F., Dürig M., Wadström J., Harder F. Role of spleen in immune response to polyvalent pneumococcal vaccine. Br Med J (Clin Res Ed) 1983 Dec 17;287(6408):1829–1832. doi: 10.1136/bmj.287.6408.1829. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Freeman R., Gould F. K. Rises in antibody to enteric gram negative bacilli after open heart surgery: a possible mechanism for postoperative pyrexia. Thorax. 1985 Jul;40(7):538–541. doi: 10.1136/thx.40.7.538. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Gryglewski A., Marcinkiewicz J., Popiela T., Ptak W. Effect of surgical trauma (gastrectomy) on cell-mediated and humoral responses in mice. Clin Exp Immunol. 1985 Jan;59(1):50–54. [PMC free article] [PubMed] [Google Scholar]
  9. Kinnaert P., Mahieu A., Van Geertruyden N. Stimulation of antibody synthesis induced by surgical trauma in rats. Clin Exp Immunol. 1978 May;32(2):243–252. [PMC free article] [PubMed] [Google Scholar]
  10. McIrvine A. J., Mannick J. A. Lymphocyte function in the critically ill surgical patient. Surg Clin North Am. 1983 Apr;63(2):245–261. doi: 10.1016/s0039-6109(16)42980-4. [DOI] [PubMed] [Google Scholar]
  11. Munster A. M. Post-traumatic immunosuppression is due to activation of suppressor T cells. Lancet. 1976 Jun 19;1(7973):1329–1330. doi: 10.1016/s0140-6736(76)92658-1. [DOI] [PubMed] [Google Scholar]
  12. Parker D. J., Cantrell J. W., Karp R. B., Stroud R. M., Digerness S. B. Changes in serum complement and immunoglobulins following cardiopulmonary bypass. Surgery. 1972 Jun;71(6):824–827. [PubMed] [Google Scholar]
  13. Slade M. S., Simmons R. L., Yunis E., Greenberg L. J. Immunodepression after major surgery in normal patients. Surgery. 1975 Sep;78(3):363–372. [PubMed] [Google Scholar]
  14. Stevens R. H., Macy E., Morrow C., Saxon A. Characterization of a circulating subpopulation of spontaneous antitetanus toxoid antibody producing B cells following in vivo booster immunization. J Immunol. 1979 Jun;122(6):2498–2504. [PubMed] [Google Scholar]
  15. Thomson P. D., Harris N. S. Detection of plaque-forming cells in the peripheral blood of actively immunized humans. J Immunol. 1977 Apr;118(4):1480–1482. [PubMed] [Google Scholar]
  16. Waldmann T. A., Broder S. Polyclonal B-cell activators in the study of the regulation of immunoglobulin synthesis in the human system. Adv Immunol. 1982;32:1–63. doi: 10.1016/s0065-2776(08)60720-8. [DOI] [PubMed] [Google Scholar]
  17. Wang B. S., Heacock E. H., Wu A. V., Mannick J. A. Generation of suppressor cells in mice after surgical trauma. J Clin Invest. 1980 Aug;66(2):200–209. doi: 10.1172/JCI109845. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Yarchoan R., Murphy B. R., Strober W., Clements M. L., Nelson D. L. In vitro production of anti-influenza virus antibody after intranasal inoculation with cold-adapted influenza virus. J Immunol. 1981 Nov;127(5):1958–1963. [PubMed] [Google Scholar]

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