Skip to main content
NCBI home page
Clinical and Experimental Immunology logoLink to Clinical and Experimental Immunology
. 1987 Jan;67(1):5–10.

Recombinant gamma interferon is a potent adjuvant for a malaria vaccine in mice.

J H Playfair, J B De Souza
PMCID: PMC1542557  PMID: 3113784

Abstract

Mice were protected against lethal Plasmodium yoelii malaria by vaccination with a Triton X-100 lysate of whole parasitized erythrocytes. For full effectiveness this vaccine required an adjuvant, and we have found that recombinant gamma-interferon has strong adjuvanticity in this model when given either intraperitoneally or subcutaneously. Specific immune responses that were enhanced included antibody, T cell help, and delayed hypersensitivity.

Full text

PDF
5

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Cottrell B. J., Playfair J. H., De Souza B. J. Cell-mediated immunity in mice vaccinated against malaria. Clin Exp Immunol. 1978 Nov;34(2):147–158. [PMC free article] [PubMed] [Google Scholar]
  2. De Maeyer E., De Maeyer-Guignard J. Host genotype influences immunomodulation by interferon. Nature. 1980 Mar 13;284(5752):173–175. doi: 10.1038/284173a0. [DOI] [PubMed] [Google Scholar]
  3. Ferreira A., Schofield L., Enea V., Schellekens H., van der Meide P., Collins W. E., Nussenzweig R. S., Nussenzweig V. Inhibition of development of exoerythrocytic forms of malaria parasites by gamma-interferon. Science. 1986 May 16;232(4752):881–884. doi: 10.1126/science.3085218. [DOI] [PubMed] [Google Scholar]
  4. Freeman R. R., Holder A. A. Characteristics of the protective response of BALB/c mice immunized with a purified Plasmodium yoelii schizont antigen. Clin Exp Immunol. 1983 Dec;54(3):609–616. [PMC free article] [PubMed] [Google Scholar]
  5. Freeman R. R., Trejdosiewicz A. J., Cross G. A. Protective monoclonal antibodies recognising stage-specific merozoite antigens of a rodent malaria parasite. Nature. 1980 Mar 27;284(5754):366–368. doi: 10.1038/284366a0. [DOI] [PubMed] [Google Scholar]
  6. Harte P. G., Cooke A., Playfair J. H. Specific monoclonal IgM is a potent adjuvant in murine malaria vaccination. Nature. 1983 Mar 17;302(5905):256–258. doi: 10.1038/302256a0. [DOI] [PubMed] [Google Scholar]
  7. Nakamura M., Manser T., Pearson G. D., Daley M. J., Gefter M. L. Effect of IFN-gamma on the immune response in vivo and on gene expression in vitro. 1984 Jan 26-Feb 1Nature. 307(5949):381–382. doi: 10.1038/307381a0. [DOI] [PubMed] [Google Scholar]
  8. Playfair J. H., De Souza J. B. Antibody responses in mice protected against malaria by vaccination. Parasite Immunol. 1979 Autumn;1(3):197–208. doi: 10.1111/j.1365-3024.1979.tb00706.x. [DOI] [PubMed] [Google Scholar]
  9. Playfair J. H., De Souza J. B., Cottrell B. J. Reactivity and crossreactivity of mouse helper T cells to malaria parasites. Immunology. 1977 May;32(5):681–687. [PMC free article] [PubMed] [Google Scholar]
  10. Playfair J. H., De Souza J. B., Freeman R. R., Holder A. A. Vaccination with a purified blood-stage malaria antigen in mice: correlation of protection with T cell mediated immunity. Clin Exp Immunol. 1985 Oct;62(1):19–23. [PMC free article] [PubMed] [Google Scholar]
  11. Playfair J. H., De Souza J. B. Vaccination of mice against malaria with soluble antigens. I. The effect of detergent, route of injection, and adjuvant. Parasite Immunol. 1986 Sep;8(5):409–414. doi: 10.1111/j.1365-3024.1986.tb00857.x. [DOI] [PubMed] [Google Scholar]
  12. Schwartz R. H. T-lymphocyte recognition of antigen in association with gene products of the major histocompatibility complex. Annu Rev Immunol. 1985;3:237–261. doi: 10.1146/annurev.iy.03.040185.001321. [DOI] [PubMed] [Google Scholar]
  13. Staruch M. J., Wood D. D. The adjuvanticity of interleukin 1 in vivo. J Immunol. 1983 May;130(5):2191–2194. [PubMed] [Google Scholar]
  14. Voller A., O'Neill P. Immunofluorescence method suitable for large-scale application to malaria. Bull World Health Organ. 1971;45(4):524–529. [PMC free article] [PubMed] [Google Scholar]
  15. Zlotnik A., Shimonkevitz R. P., Gefter M. L., Kappler J., Marrack P. Characterization of the gamma-interferon-mediated induction of antigen-presenting ability in P388D1 cells. J Immunol. 1983 Dec;131(6):2814–2820. [PubMed] [Google Scholar]

Articles from Clinical and Experimental Immunology are provided here courtesy of British Society for Immunology

RESOURCES