Skip to main content
Clinical and Experimental Immunology logoLink to Clinical and Experimental Immunology
. 1987 Mar;67(3):516–523.

Profile of autoantibodies in the serum of patients with tuberculosis, klebsiella and other Gram-negative infections

D A Isenberg, P Maddison, G Swana, R P Skinner, M Swana, M Jones, I Addison, C Dudeney, S Shall, A El Roiey, Y Shoenfeld
PMCID: PMC1542633  PMID: 3301097

Abstract

Autoantibody profiles were examined in the sera of untreated patients with tuberculosis, and those with klebsiella septicaemia, and klebsiella and E. coli urinary tract infections. Rheumatoid factors of the IgM, IgA and IgG isotypes, antinuclear antibodies and antibodies to poly(ADP-ribose) were all frequently detected (generally 15-40%). In contrast, antibodies to the extractable nuclear antigens and to the organ specific antigens were unusual (generally <10%). In comparison, in a group of lupus patients IgM rheumatoid factor, anti-nuclear antibodies, antibodies to poly(ADP-ribose) and antibodies to the extractable nuclear antigens were more frequently found, but IgA and IgG rheumatoid factors and antibodies to the organ-specific antigens were present in much the same frequency.

Full text

PDF
516

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aoki S., Ikuta K., Aoyama G. Induction of chronic polyarthritis in rabbits. Nature. 1972 May 19;237(5351):168–169. doi: 10.1038/237168a0. [DOI] [PubMed] [Google Scholar]
  2. Banck G., Forsgren A. Many bacterial species are mitogenic for human blood B lymphocytes. Scand J Immunol. 1978;8(4):347–354. doi: 10.1111/j.1365-3083.1978.tb00528.x. [DOI] [PubMed] [Google Scholar]
  3. Cannat A., Seligmann M. Possible induction of antinuclear antibodies by isoniazid. Lancet. 1966 Jan 22;1(7430):185–187. doi: 10.1016/s0140-6736(66)90704-5. [DOI] [PubMed] [Google Scholar]
  4. Cayzer I., Chalmers S. R., Doniach D., Swana G. An evaluation of two new haemagglutination tests for the rapid diagnosis of autoimmune thyroid diseases. J Clin Pathol. 1978 Dec;31(12):1147–1151. doi: 10.1136/jcp.31.12.1147. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Clayton A. L., Bernstein R. M., Tavassoli M., Shall S., Bunn C., Hughes G. R., Chantler S. M. Measurement of antibody to poly (adenosine diphosphate-ribose): its diagnostic value in systemic lupus erythematosus. Clin Exp Immunol. 1984 May;56(2):263–271. [PMC free article] [PubMed] [Google Scholar]
  6. Cohen I. R., Holoshitz J., van Eden W., Frenkel A. T lymphocyte clones illuminate pathogenesis and affect therapy of experimental arthritis. Arthritis Rheum. 1985 Aug;28(8):841–845. doi: 10.1002/art.1780280802. [DOI] [PubMed] [Google Scholar]
  7. Cooke A., Lydyard P. M., Roitt I. M. Autoimmunity and idiotypes. Lancet. 1984 Sep 29;2(8405):723–725. doi: 10.1016/s0140-6736(84)92628-x. [DOI] [PubMed] [Google Scholar]
  8. Dudeney C., Shoenfeld Y., Rauch J., Jones M., Mackworth Young C., Tavassoli M., Shall S., Isenberg D. A. A study of anti-poly (ADP-ribose) antibodies and an anti-DNA antibody idiotype and other immunological abnormalities in lupus family members. Ann Rheum Dis. 1986 Jun;45(6):502–507. doi: 10.1136/ard.45.6.502. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Ebringer A., Ptaszynska T., Corbett M., Wilson C., Macafee Y., Avakian H., Baron P., James D. C. Antibodies to proteus in rheumatoid arthritis. Lancet. 1985 Aug 10;2(8450):305–307. doi: 10.1016/s0140-6736(85)90352-6. [DOI] [PubMed] [Google Scholar]
  10. Fritzler M. J., Pauls J. D., Kinsella T. D., Bowen T. J. Antinuclear, anticytoplasmic, and anti-Sjogren's syndrome antigen A (SS-A/Ro) antibodies in female blood donors. Clin Immunol Immunopathol. 1985 Jul;36(1):120–128. doi: 10.1016/0090-1229(85)90045-5. [DOI] [PubMed] [Google Scholar]
  11. Hothersall T. E., Mowat A. G., Duthie J. J., Alexander W. R. Drug-induced lupus syndrome. A case report implicating isoniazid. Scott Med J. 1967 Jul;13(7):245–247. [PubMed] [Google Scholar]
  12. Kanai Y., Fujiwara M. Naturally occurring antibodies to poly(ADP-ribose) in autoimmune MRL/Mp-lpr/lpr mice. Clin Exp Immunol. 1985 Jan;59(1):132–138. [PMC free article] [PubMed] [Google Scholar]
  13. Lee S. L., Rivero I., Siegel M. Activation of systemic lupus erythematosus by drugs. Arch Intern Med. 1966 May;117(5):620–626. [PubMed] [Google Scholar]
  14. Lindqvist K. J., Coleman R. E., Osterland C. K. Autoantibodies in chronic pulmonary tuberculosis. J Chronic Dis. 1970 Apr;22(11):717–725. doi: 10.1016/0021-9681(70)90047-0. [DOI] [PubMed] [Google Scholar]
  15. Maddison P. J., Skinner R. P., Vlachoyiannopoulos P., Brennand D. M., Hough D. Antibodies to nRNP, Sm, Ro(SSA) and La(SSB) detected by ELISA: their specificity and inter-relations in connective tissue disease sera. Clin Exp Immunol. 1985 Nov;62(2):337–345. [PMC free article] [PubMed] [Google Scholar]
  16. Naparstek Y., Duggan D., Schattner A., Madaio M. P., Goni F., Frangione B., Stollar B. D., Kabat E. A., Schwartz R. S. Immunochemical similarities between monoclonal antibacterial Waldenstrom's macroglobulins and monoclonal anti-DNA lupus autoantibodies. J Exp Med. 1985 Jun 1;161(6):1525–1538. doi: 10.1084/jem.161.6.1525. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Okolie E. E., Shall S. The significance of antibodies to poly(adenosine diphosphate-ribose) in systemic lupus erythematosus. Clin Exp Immunol. 1979 Apr;36(1):151–164. [PMC free article] [PubMed] [Google Scholar]
  18. PEARSON C. M. Development of arthritis, periarthritis and periostitis in rats given adjuvants. Proc Soc Exp Biol Med. 1956 Jan;91(1):95–101. doi: 10.3181/00379727-91-22179. [DOI] [PubMed] [Google Scholar]
  19. SINGER J. M., PLOTZ C. M., PERLATA F. M., LYONS H. C. The presence of anti-gamma globulin factors in sera of patients with active pulmonary tuberculosis. Ann Intern Med. 1962 Apr;56:545–552. doi: 10.7326/0003-4819-56-4-545. [DOI] [PubMed] [Google Scholar]
  20. Shoenfeld Y., Isenberg D. A., Rauch J., Madaio M. P., Stollar B. D., Schwartz R. S. Idiotypic cross-reactions of monoclonal human lupus autoantibodies. J Exp Med. 1983 Sep 1;158(3):718–730. doi: 10.1084/jem.158.3.718. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Shoenfeld Y., Schwartz R. S. Immunologic and genetic factors in autoimmune diseases. N Engl J Med. 1984 Oct 18;311(16):1019–1029. doi: 10.1056/NEJM198410183111605. [DOI] [PubMed] [Google Scholar]
  22. Stefansson K., Dieperink M. E., Richman D. P., Gomez C. M., Marton L. S. Sharing of antigenic determinants between the nicotinic acetylcholine receptor and proteins in Escherichia coli, Proteus vulgaris, and Klebsiella pneumoniae. Possible role in the pathogenesis of myasthenia gravis. N Engl J Med. 1985 Jan 24;312(4):221–225. doi: 10.1056/NEJM198501243120407. [DOI] [PubMed] [Google Scholar]
  23. Tardieu M., Powers M. L., Hafler D. A., Hauser S. L., Weiner H. L. Autoimmunity following viral infection: demonstration of monoclonal antibodies against normal tissue following infection of mice with reovirus and demonstration of shared antigenicity between virus and lymphocytes. Eur J Immunol. 1984 Jun;14(6):561–565. doi: 10.1002/eji.1830140614. [DOI] [PubMed] [Google Scholar]

Articles from Clinical and Experimental Immunology are provided here courtesy of British Society for Immunology

RESOURCES