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. 1987 Jun;68(3):479–487.

Impaired anti-pneumococcal antibody response in patients with AIDS-related persistent generalized lymphadenopathy.

J J Ballet 1, G Sulcebe 1, L J Couderc 1, F Danon 1, C Rabian 1, M Lathrop 1, J P Clauvel 1, M Seligmann 1
PMCID: PMC1542747  PMID: 3652522

Abstract

Pre- and post-immunization serum antibodies to pneumococcal polysaccharides (PPS) and tetanus toxoid (TT) were measured in 25 patients with persistent generalized lymphadenopathy and serum antibodies to the human immunodeficiency virus (HIV). The increase in post-immunization anti-PPS antibodies was lower than 40% in 16/25 patients. Isotype analysis indicated that the IgM, IgA, IgG2, but not the IgG1 antibody responses were lower in patients that in healthy controls, whereas pre-immunization values were similar. For TT, no difference was found between the patients and the healthy group in total and IgG1 antibody response whereas IgG4 response was lower in patients. No significant association was found between the defect in anti-PPS antibody response and associated thrush or constitutional symptoms or other immunological parameters. These findings suggest that defective response to a thymo-independent polysaccharide antigen is a distinctive consequence of HIV infection.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abrams D. I., Lewis B. J., Beckstead J. H., Casavant C. A., Drew W. L. Persistent diffuse lymphadenopathy in homosexual men: endpoint or prodrome? Ann Intern Med. 1984 Jun;100(6):801–808. doi: 10.7326/0003-4819-100-6-801. [DOI] [PubMed] [Google Scholar]
  2. Amlot P. L., Hayes A. E. Impaired human antibody response to the thymus-independent antigen, DNP-Ficoll, after splenectomy. Implications for post-splenectomy infections. Lancet. 1985 May 4;1(8436):1008–1011. doi: 10.1016/s0140-6736(85)91613-7. [DOI] [PubMed] [Google Scholar]
  3. Ammann A. J., Schiffman G., Abrams D., Volberding P., Ziegler J., Conant M. B-cell immunodeficiency in acquired immune deficiency syndrome. JAMA. 1984 Mar 16;251(11):1447–1449. [PubMed] [Google Scholar]
  4. Aucouturier P., Danon F., Daveau M., Guillou B., Sabbah A., Besson J., Preud'homme J. L. Measurement of serum IgG4 levels by a competitive immunoenzymatic assay with monoclonal antibodies. J Immunol Methods. 1984 Nov 16;74(1):151–162. doi: 10.1016/0022-1759(84)90376-4. [DOI] [PubMed] [Google Scholar]
  5. Ballet J. J., Rabian-Herzog C., Lathrop M., Bourge J. F., Agrapart M., Drouet J., Lalouel J. M., Dausset J. Specific immune responses after booster immunization with tetanus toxoid in man: study of kinetics, family segregation, and linkage to HLA of in vitro lymphocyte proliferative responses and serum-antibody responses. Immunogenetics. 1983;18(4):343–358. doi: 10.1007/BF00372467. [DOI] [PubMed] [Google Scholar]
  6. Bird P., Lowe J., Stokes R. P., Bird A. G., Ling N. R., Jefferis R. The separation of human serum IgG into subclass fractions by immunoaffinity chromatography and assessment of specific antibody activity. J Immunol Methods. 1984 Jun 8;71(1):97–105. doi: 10.1016/0022-1759(84)90209-6. [DOI] [PubMed] [Google Scholar]
  7. Brun-Vezinet F., Rouzioux C., Barre-Sinoussi F., Klatzmann D., Saimot A. G., Rozenbaum W., Christol D., Gluckmann J. C., Montagnier L., Chermann J. C. Detection of IgG antibodies to lymphadenopathy-associated virus in patients with AIDS or lymphadenopathy syndrome. Lancet. 1984 Jun 9;1(8389):1253–1256. doi: 10.1016/s0140-6736(84)92444-9. [DOI] [PubMed] [Google Scholar]
  8. Dupuy J. M., Preud'Homme J. L. Exploration de l'hypersensibilité retardée par le 2,4 dinitrochlorobënzène (DNCB) Presse Med. 1968 Jan 20;76(3):123–124. [PubMed] [Google Scholar]
  9. Eisenberg R. A., Dyer K., Craven S. Y., Fuller C. R., Yount W. J. Subclass restriction and polyclonality of the systemic lupus erythematosus marker antibody anti-Sm. J Clin Invest. 1985 Apr;75(4):1270–1277. doi: 10.1172/JCI111826. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Freijd A., Hammarström L., Persson M. A., Smith C. I. Plasma anti-pneumococcal antibody activity of the IgG class and subclasses in otitis prone children. Clin Exp Immunol. 1984 May;56(2):233–238. [PMC free article] [PubMed] [Google Scholar]
  11. Hammarström L., Persson M. A., Smith C. I. Immunoglobulin subclass distribution of human anti-carbohydrate antibodies: aberrant pattern in IgA-deficient donors. Immunology. 1985 Apr;54(4):821–826. [PMC free article] [PubMed] [Google Scholar]
  12. Ioachim H. L., Lerner C. W., Tapper M. L. Lymphadenopathies in homosexual men. Relationships with the acquired immune deficiency syndrome. JAMA. 1983 Sep 9;250(10):1306–1309. doi: 10.1001/jama.250.10.1306. [DOI] [PubMed] [Google Scholar]
  13. Janossy G., Pinching A. J., Bofill M., Weber J., McLaughlin J. E., Ornstein M., Ivory K., Harris J. R., Favrot M., Macdonald-Burns D. C. An immunohistological approach to persistent lymphadenopathy and its relevance to AIDS. Clin Exp Immunol. 1985 Feb;59(2):257–266. [PMC free article] [PubMed] [Google Scholar]
  14. Kehrl J. H., Fauci A. S. Activation of human B lymphocytes after immunization with pneumococcal polysaccharides. J Clin Invest. 1983 Apr;71(4):1032–1040. doi: 10.1172/JCI110830. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Klein R. S., Harris C. A., Small C. B., Moll B., Lesser M., Friedland G. H. Oral candidiasis in high-risk patients as the initial manifestation of the acquired immunodeficiency syndrome. N Engl J Med. 1984 Aug 9;311(6):354–358. doi: 10.1056/NEJM198408093110602. [DOI] [PubMed] [Google Scholar]
  16. Lane H. C., Depper J. M., Greene W. C., Whalen G., Waldmann T. A., Fauci A. S. Qualitative analysis of immune function in patients with the acquired immunodeficiency syndrome. Evidence for a selective defect in soluble antigen recognition. N Engl J Med. 1985 Jul 11;313(2):79–84. doi: 10.1056/NEJM198507113130204. [DOI] [PubMed] [Google Scholar]
  17. Lane H. C., Masur H., Edgar L. C., Whalen G., Rook A. H., Fauci A. S. Abnormalities of B-cell activation and immunoregulation in patients with the acquired immunodeficiency syndrome. N Engl J Med. 1983 Aug 25;309(8):453–458. doi: 10.1056/NEJM198308253090803. [DOI] [PubMed] [Google Scholar]
  18. Lowe J., Bird P., Hardie D., Jefferis R., Ling N. R. Monoclonal antibodies (McAbs) to determinants on human gamma chains: properties of antibodies showing subclass restriction or subclass specificity. Immunology. 1982 Oct;47(2):329–336. [PMC free article] [PubMed] [Google Scholar]
  19. Murray H. W., Hillman J. K., Rubin B. Y., Kelly C. D., Jacobs J. L., Tyler L. W., Donelly D. M., Carriero S. M., Godbold J. H., Roberts R. B. Patients at risk for AIDS-related opportunistic infections. Clinical manifestations and impaired gamma interferon production. N Engl J Med. 1985 Dec 12;313(24):1504–1510. doi: 10.1056/NEJM198512123132403. [DOI] [PubMed] [Google Scholar]
  20. Pahwa S. G., Quilop M. T., Lange M., Pahwa R. N., Grieco M. H. Defective B-lymphocyte function in homosexual men in relation to the acquired immunodeficiency syndrome. Ann Intern Med. 1984 Dec;101(6):757–763. doi: 10.7326/0003-4819-101-6-757. [DOI] [PubMed] [Google Scholar]
  21. Pahwa S., Pahwa R., Saxinger C., Gallo R. C., Good R. A. Influence of the human T-lymphotropic virus/lymphadenopathy-associated virus on functions of human lymphocytes: evidence for immunosuppressive effects and polyclonal B-cell activation by banded viral preparations. Proc Natl Acad Sci U S A. 1985 Dec;82(23):8198–8202. doi: 10.1073/pnas.82.23.8198. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Persson M. A., Hammarström L., Smith C. I. Enzyme-linked immunosorbent assay for subclass distribution of human IgG and IgA antigen-specific antibodies. J Immunol Methods. 1985 Apr 8;78(1):109–121. doi: 10.1016/0022-1759(85)90334-5. [DOI] [PubMed] [Google Scholar]
  23. Schiffman G., Douglas R. M., Bonner M. J., Robbins M., Austrian R. A radioimmunoassay for immunologic phenomena in pneumococcal disease and for the antibody response to pneumococcal vaccines. I. Method for the radioimmunoassay of anticapsular antibodies and comparison with other techniques. J Immunol Methods. 1980;33(2):133–144. doi: 10.1016/s0022-1759(80)80004-4. [DOI] [PubMed] [Google Scholar]
  24. Schiffman G. Pneumococcal vaccine: a tool for the evaluation of the B-cell function of the immune system. Proc Soc Exp Biol Med. 1983 Dec;174(3):309–315. doi: 10.3181/00379727-174-41742. [DOI] [PubMed] [Google Scholar]
  25. Seligmann M., Chess L., Fahey J. L., Fauci A. S., Lachmann P. J., L'Age-Stehr J., Ngu J., Pinching A. J., Rosen F. S., Spira T. J. AIDS--an immunologic reevaluation. N Engl J Med. 1984 Nov 15;311(20):1286–1292. doi: 10.1056/NEJM198411153112005. [DOI] [PubMed] [Google Scholar]
  26. Seppälä I. J., Routonen N., Sarnesto A., Mattila P. A., Mäkelä O. The percentages of six immunoglobulin isotypes in human antibodies to tetanus toxoid: standardization of isotype-specific second antibodies in solid-phase assay. Eur J Immunol. 1984 Sep;14(9):868–875. doi: 10.1002/eji.1830140918. [DOI] [PubMed] [Google Scholar]
  27. Shannon K. M., Ammann A. J. Acquired immune deficiency syndrome in childhood. J Pediatr. 1985 Feb;106(2):332–342. doi: 10.1016/s0022-3476(85)80320-6. [DOI] [PubMed] [Google Scholar]
  28. Siber G. R., Ransil B. J. Methods for the analysis of antibody responses to vaccines or other immune stimuli. Methods Enzymol. 1983;93:60–78. doi: 10.1016/s0076-6879(83)93034-3. [DOI] [PubMed] [Google Scholar]
  29. Simberkoff M. S., El Sadr W., Schiffman G., Rahal J. J., Jr Streptococcus pneumoniae infections and bacteremia in patients with acquired immune deficiency syndrome, with report of a pneumococcal vaccine failure. Am Rev Respir Dis. 1984 Dec;130(6):1174–1176. doi: 10.1164/arrd.1984.130.6.1174. [DOI] [PubMed] [Google Scholar]
  30. Steward M. W., Lew A. M. The importance of antibody affinity in the performance of immunoassays for antibody. J Immunol Methods. 1985 Apr 22;78(2):173–190. doi: 10.1016/0022-1759(85)90074-2. [DOI] [PubMed] [Google Scholar]

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