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. 1987 Jun;68(3):613–620.

Pyrimidinone (bropirimine) mediated alteration of T lymphocyte subsets during murine cytomegalovirus infection.

R J Brideau 1, J A Nicholas 1
PMCID: PMC1542767  PMID: 2820635

Abstract

Murine cytomegalovirus (MCMV) infection of mice resulted in suppression of mitogen induced proliferation and interleukin 2 (IL-2) responses of splenic cells. This suppression was also evident as a reduction in the number of cells expressing Thy-1 or L3T4 and a reduction in the ratio of T helper/T suppressor cells. The pyrimidinone compound, bropirimine, when administered to MCMV infected mice was able to restore mitogen-induced proliferative and IL-2 responses of splenic cells, to increase the number of cells expressing Thy-1 or L3T4, to restore the ratio of T helper/T suppressor cells and to increase the number of cells inducible for expression of IL-2 receptors.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bismuth G., Moreau J. L., Sommé G., Duphot M., Dautry-Varsat A., Robb R. J., Théze J. Regulation of interleukin 2 (IL2) receptor expression: IL2 as an inducing signal for the expression of its own receptor on a murine T helper cell line. Eur J Immunol. 1985 Jul;15(7):723–727. doi: 10.1002/eji.1830150716. [DOI] [PubMed] [Google Scholar]
  2. Brideau R. J., Wolcott J. A. Effect of pyrimidinone treatment on lethal and immunosuppressive murine cytomegalovirus infection. Antimicrob Agents Chemother. 1985 Oct;28(4):485–488. doi: 10.1128/aac.28.4.485. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Carney W. P., Rubin R. H., Hoffman R. A., Hansen W. P., Healey K., Hirsch M. S. Analysis of T lymphocyte subsets in cytomegalovirus mononucleosis. J Immunol. 1981 Jun;126(6):2114–2116. [PubMed] [Google Scholar]
  4. Cohen J. I., Corey G. R. Cytomegalovirus infection in the normal host. Medicine (Baltimore) 1985 Mar;64(2):100–114. doi: 10.1097/00005792-198503000-00003. [DOI] [PubMed] [Google Scholar]
  5. Dialynas D. P., Quan Z. S., Wall K. A., Pierres A., Quintáns J., Loken M. R., Pierres M., Fitch F. W. Characterization of the murine T cell surface molecule, designated L3T4, identified by monoclonal antibody GK1.5: similarity of L3T4 to the human Leu-3/T4 molecule. J Immunol. 1983 Nov;131(5):2445–2451. [PubMed] [Google Scholar]
  6. Doody D. P., Wilson E. J., Medearis D. N., Rubin R. H. Changes in the phenotype of T-cell subset determinants following murine cytomegalovirus infection. Clin Immunol Immunopathol. 1986 Sep;40(3):466–475. doi: 10.1016/0090-1229(86)90191-1. [DOI] [PubMed] [Google Scholar]
  7. Farrar W. L., Cleveland J. L., Beckner S. K., Bonvini E., Evans S. W. Biochemical and molecular events associated with interleukin 2 regulation of lymphocyte proliferation. Immunol Rev. 1986 Aug;92:49–65. doi: 10.1111/j.1600-065x.1986.tb01493.x. [DOI] [PubMed] [Google Scholar]
  8. Ho M. Immunology of cytomegalovirus: immunosuppressive effects during infections. Birth Defects Orig Artic Ser. 1984;20(1):131–147. [PubMed] [Google Scholar]
  9. Kelsey D. K., Kern E. R., Overall J. C., Jr, Glasgow L. A. Effect of cytosine arabinoside and 5-iodo-2'-deoxyuridine on a cytomegalovirus infection in newborn mice. Antimicrob Agents Chemother. 1976 Mar;9(3):458–464. doi: 10.1128/aac.9.3.458. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Kelsey D. K., Overall J. C., Jr, Glasgow L. A. Correlation of the suppression of mitogen responsiveness and the mixed lymphocyte reaction with the proliferative response to viral antigen of splenic lymphocytes from cytomegalovirus-infected mice. J Immunol. 1978 Aug;121(2):464–470. [PubMed] [Google Scholar]
  11. Kinney J. S., Onorato I. M., Stewart J. A., Pass R. F., Stagno S., Cheeseman S. H., Chin J., Kumar M. L., Yaeger A. S., Herrmann K. L. Cytomegaloviral infection and disease. J Infect Dis. 1985 May;151(5):772–774. doi: 10.1093/infdis/151.5.772. [DOI] [PubMed] [Google Scholar]
  12. Larsson E. L., Iscove N. N., Coutinho A. Two distinct factors are required for induction of T-cell growth. Nature. 1980 Feb 14;283(5748):664–666. doi: 10.1038/283664a0. [DOI] [PubMed] [Google Scholar]
  13. Li L. H., Johnson M. A., Moeller R. B., Wallace T. L. Chemoimmunotherapy of B 16 melanoma and P388 leukemia with cyclophosphamide and pyrimidinones. Cancer Res. 1984 Jul;44(7):2841–2847. [PubMed] [Google Scholar]
  14. Li L. H., Wallace T. L., Richard K. A., Tracey D. E. Mechanism of antitumor action of pyrimidinones in the treatment of B16 melanoma and P388 leukemia. Cancer Res. 1985 Feb;45(2):532–538. [PubMed] [Google Scholar]
  15. Loh L., Hudson J. B. Immunosuppressive effect of murine cytomegalovirus. Infect Immun. 1980 Jan;27(1):54–60. doi: 10.1128/iai.27.1.54-60.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Loh L., Hudson J. B. Murine cytomegalovirus infection in the spleen and its relationship to immunosuppression. Infect Immun. 1981 Jun;32(3):1067–1072. doi: 10.1128/iai.32.3.1067-1072.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Lotzová E., Savary C. A., Stringfellow D. A. 5-halo-6-phenyl pyrimidinones: new molecules with cancer therapeutic potential and interferon-inducing capacity are strong inducers of murine natural killer cells. J Immunol. 1983 Feb;130(2):965–969. [PubMed] [Google Scholar]
  18. Malek T. R., Robb R. J., Shevach E. M. Identification and initial characterization of a rat monoclonal antibody reactive with the murine interleukin 2 receptor-ligand complex. Proc Natl Acad Sci U S A. 1983 Sep;80(18):5694–5698. doi: 10.1073/pnas.80.18.5694. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Reuben J. M., Hersh E. M., Murray J. L., Munn C. G., Mehta S. R., Mansell P. W. IL-2 production and response in vitro by the leukocytes of patients with acquired immune deficiency syndrome. Lymphokine Res. 1985 Spring;4(2):103–116. [PubMed] [Google Scholar]
  20. Rinaldo C. R., Jr, Carney W. P., Richter B. S., Black P. H., Hirsch M. S. Mechanisms of immunosuppression in cytomegaloviral mononucleosis. J Infect Dis. 1980 Apr;141(4):488–495. doi: 10.1093/infdis/141.4.488. [DOI] [PubMed] [Google Scholar]
  21. Sell M. S., Bale J. F., Jr, Giller R. H. T-lymphocyte subpopulations and function during murine cytomegalovirus infection. Pediatr Res. 1985 Jun;19(6):583–587. doi: 10.1203/00006450-198506000-00016. [DOI] [PubMed] [Google Scholar]
  22. Smith K. A., Lachman L. B., Oppenheim J. J., Favata M. F. The functional relationship of the interleukins. J Exp Med. 1980 Jun 1;151(6):1551–1556. doi: 10.1084/jem.151.6.1551. [DOI] [PMC free article] [PubMed] [Google Scholar]

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