Abstract
A case of sexual precocity of unusually early onset and associated with a hypothalamic tumour is described. The effects of ethinyl oestradiol and medroxyprogesterone acetate treatment have been monitored by plasma testosterone, FSH, and LH estimations. The results suggested a partial suppression of the tumour's influence, the mechanism of which is discussed.
Full text
PDF



Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Collins W. P., Mansfield M. D., Alladina N. S., Sommerville I. F. Radioimmunoassay of plasma testosterone. J Steroid Biochem. 1972 Apr;3(3):333–348. doi: 10.1016/0022-4731(72)90080-5. [DOI] [PubMed] [Google Scholar]
- Franchimont P., Legros J. J., Meurice J. Effect of several estrogens on serum gonadotropin levels in postmenopausal women. Horm Metab Res. 1972 Jul;4(4):288–292. doi: 10.1055/s-0028-1094069. [DOI] [PubMed] [Google Scholar]
- Gray C. H., Baron D. N., Brooks R. V., James V. H. A critical appraisal of a method fo estimating urinary 17-oxosteroids and total 17-oxogenic steroids. A memorandum prepared at the request of the clinical Endocrinology Committee of the Medical Research Council. Lancet. 1969 Jan 18;1(7586):124–127. doi: 10.1016/s0140-6736(69)91137-4. [DOI] [PubMed] [Google Scholar]
- JOHNSEN S. G. A clinical routine-method for the quantitative determination of gonadotrophins in 24-hour urine samples. Acta Endocrinol (Copenh) 1958 May;28(1):69–88. doi: 10.1530/acta.0.0280069. [DOI] [PubMed] [Google Scholar]
- Kelch R. P., Kaplan S. L., Ghumbach M. M. Suppression of urinary and plasma follicle-stimulating hormone by exogenous estrogens in prepubertal and pubertal children. J Clin Invest. 1973 May;52(5):1122–1128. doi: 10.1172/JCI107278. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kulin H. E., Reiter E. O. Gonadotropin suppression by low dose estrogen in men: evidence for differential effects upon FSH and LH. J Clin Endocrinol Metab. 1972 Dec;35(6):836–839. doi: 10.1210/jcem-35-6-836. [DOI] [PubMed] [Google Scholar]
- Monroe S. E., Jaffe R. B., Midgley A. R., Jr Regulation of human gonadotropins. XII. Increase in serum gonadotropins in response to estradiol. J Clin Endocrinol Metab. 1972 Feb;34(2):342–347. doi: 10.1210/jcem-34-2-342. [DOI] [PubMed] [Google Scholar]

