Skip to main content
NCBI home page
Archives of Disease in Childhood logoLink to Archives of Disease in Childhood
. 1975 Apr;50(4):304–307. doi: 10.1136/adc.50.4.304

Serum levels of lysozyme in term and preterm newborns.

M Xanthou, A Agathopoulos, A Sakellariou, C Economou-Mavrou, S Tsingoglou, N Matsaniotis
PMCID: PMC1544467  PMID: 1147669

Abstract

Serum lysozyme levels were studied in term babies at the time of delivery and again between 7th and 30th postnatal days, and in preterm babies on the 1st, 3rd, and 5th postnatal days. Levels in term babies at delivery (mean 2.28 mug/ml) were similar to those found in adults, but they fell between the 7th and 30th postnatal days. In premature babies lysozyme levels on the first day of live (mean (0.82 mug/ml) were lower than in term babies. They tended to rise during the first 5 days, by which time they had reached levels found in term babies between the 7th and 30th days. The low lysozyme levels in preterm and in term babies after the first few days of life may contribute to the poor ability of the newborn baby to localize infection and to kill bacteria extracellularly.

Full text

PDF
304

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Barratt T. M., Crawford R. Lysozyme excretion as a measure of renal tubular dysfunction in children. Clin Sci. 1970 Sep;39(3):457–465. doi: 10.1042/cs0390457. [DOI] [PubMed] [Google Scholar]
  2. CARSON M. E., DANNENBERG A. M., Jr HYDROLYTIC ENZYMES OF RABBIT MONONUCLEAR EXUDATE CELLS. II. LYSOZYME: PROPERTIES AND QUANTITATIVE ASSAY IN TUBERCULOUS AND CONTROL INBRED RABBITS. J Immunol. 1965 Jan;94:99–104. [PubMed] [Google Scholar]
  3. Catovsky D., Galton D. A., Griffin C., Hoffbrand A. V., Szur L. Serum lysozyme and vitamin B 12 binding capacity in myeloproliferative disorders. Br J Haematol. 1971 Dec;21(6):661–672. doi: 10.1111/j.1365-2141.1971.tb02728.x. [DOI] [PubMed] [Google Scholar]
  4. Fink M. E., Finch S. C. Serum muramidase and granulocyte turnover. Proc Soc Exp Biol Med. 1968 Feb;127(2):365–367. doi: 10.3181/00379727-127-32692. [DOI] [PubMed] [Google Scholar]
  5. Gajdos A. Biochimie des lysozymes. Presse Med. 1971 Feb 13;79(8):351–354. [PubMed] [Google Scholar]
  6. Glynn A. A., Martin W., Adinolfi M. Levels of lysozyme in human foetuses and newborns. Nature. 1970 Jan 3;225(5227):77–78. doi: 10.1038/225077a0. [DOI] [PubMed] [Google Scholar]
  7. Hansen N. E., Andersen V. Lysozyme activity in human neutrophilic granulocytes. Br J Haematol. 1973 May;24(5):613–623. doi: 10.1111/j.1365-2141.1973.tb01687.x. [DOI] [PubMed] [Google Scholar]
  8. Hansen N. E., Karle H., Andersen V. Muramidase activity of bone marrow plasma. Studies in haematologically normal individuals and in granulocytopenic patients. Acta Med Scand. 1969 May;185(5):387–392. [PubMed] [Google Scholar]
  9. Hansen N. E., Karle H., Andersen V., Olgaard K. Lysozyme turnover in man. J Clin Invest. 1972 May;51(5):1146–1155. doi: 10.1172/JCI106907. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Hansen N. E. The relationship between the turnover rate of neutrophilic granulocytes and plasma lysozyme levels. Br J Haematol. 1973 Dec;25(6):771–782. doi: 10.1111/j.1365-2141.1973.tb01789.x. [DOI] [PubMed] [Google Scholar]
  11. Iwaszko-Krawczuk W. Serum lysozyme activity in the small-for-dates newborn. Acta Paediatr Acad Sci Hung. 1973;14(2):135–138. [PubMed] [Google Scholar]
  12. Jensen H. Renal handling of muramidase in patients with kidney diseases or hypertension. Scand J Clin Lab Invest. 1973 Oct;32(2):111–115. doi: 10.3109/00365517309084337. [DOI] [PubMed] [Google Scholar]
  13. Miller T. E. Killing and lysis of gram-negative bacteria through the synergistic effect of hydrogen peroxide, ascorbic acid, and lysozyme. J Bacteriol. 1969 Jun;98(3):949–955. doi: 10.1128/jb.98.3.949-955.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Osserman E. F., Lawlor D. P. Serum and urinary lysozyme (muramidase) in monocytic and monomyelocytic leukemia. J Exp Med. 1966 Nov 1;124(5):921–952. doi: 10.1084/jem.124.5.921. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. PARRY R. M., Jr, CHANDAN R. C., SHAHANI K. M. A RAPID AND SENSITIVE ASSAY OF MURAMIDASE. Proc Soc Exp Biol Med. 1965 Jun;119:384–386. doi: 10.3181/00379727-119-30188. [DOI] [PubMed] [Google Scholar]
  16. SALTON M. R. The properties of lysozyme and its action on microorganisms. Bacteriol Rev. 1957 Jun;21(2):82–100. doi: 10.1128/br.21.2.82-100.1957. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Weissmann G. The role of lysosomes in inflammation and disease. Annu Rev Med. 1967;18:97–112. doi: 10.1146/annurev.me.18.020167.000525. [DOI] [PubMed] [Google Scholar]
  18. Wright D. G., Malawista S. E. The mobilization and extracellular release of granular enzymes from human leukocytes during phagocytosis. J Cell Biol. 1972 Jun;53(3):788–797. doi: 10.1083/jcb.53.3.788. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Xanthou M. Leucocyte blood picture in healthy full-term and premature babies during neonatal period. Arch Dis Child. 1970 Apr;45(240):242–249. doi: 10.1136/adc.45.240.242. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Archives of Disease in Childhood are provided here courtesy of BMJ Publishing Group

RESOURCES