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. 1975 Jul;50(7):559–561. doi: 10.1136/adc.50.7.559

Lymphocyte response to hepatitis B surface antigen. Findings in hepatitis and Indian childhood cirrhosis.

R K Chandra
PMCID: PMC1544585  PMID: 810095

Abstract

The lymphocyte delayed hypersensitivity response to phytohaemagglutinin (PHA) and hepatitis B antigen (HBsAG) was evaluated by two in vitro tests-leucocyte migration inhibition and DNA synthesis. Patients convalescing from HBsAG-positive hepatits showed the presence of a state of cell-mediated immune responsiveness to the antigen. In Indian childhood cirrhosis, there was a failure of response to HBsAG and a slight but significant depression of reaction to PHA. It is suggested that the lack of immune reactivity to HBsAG, perhaps determined genetically, may be a significant factor in the evolution of cirrhosis in Indian children.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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