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. 1975 Jul;50(7):532–534. doi: 10.1136/adc.50.7.532

Food antibodies in malnutrition.

R K Chandra
PMCID: PMC1544594  PMID: 1167064

Abstract

Antibodies to several food proteins were detected in the serum of 13 out of 20 malnourished children. Antibody activity was found mainly in the IgG and IgA classes. On ingestion of food items to which antibodies were demonstrated, no untoward symptom occurred nor was complement activation observed in vivo. It is suggested that food antibodies in malnourished children result from atrophied gut mucosa and reduced secretory immune response, which permit passage of intact or incompletely digested protein molecules, and impaired phagocytic function of hepatic reticuloendothelial system. Such antibodies do not appear to play any immediate immunopathological role.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Amin K., Walia B. N., Ghai O. P. Small bowel functions and structure in malnourished children. Indian Pediatr. 1969 Feb;6(2):67–72. [PubMed] [Google Scholar]
  2. BOYDEN S. V. The adsorption of proteins on erythrocytes treated with tannic acid and subsequent hemagglutination by antiprotein sera. J Exp Med. 1951 Feb;93(2):107–120. doi: 10.1084/jem.93.2.107. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Buckley R. H., Dees S. C. Correlation of milk precipitins with IgA deficiency. N Engl J Med. 1969 Aug 28;281(9):465–469. doi: 10.1056/NEJM196908282810903. [DOI] [PubMed] [Google Scholar]
  4. Chandra R. K. Immunocompetence in undernutrition. J Pediatr. 1972 Dec;81(6):1194–1200. doi: 10.1016/s0022-3476(72)80262-2. [DOI] [PubMed] [Google Scholar]
  5. Chandra R. K. Letter: Immunocompetence in low-birth-weight infants after intrauterine malnutrition. Lancet. 1974 Dec 7;2(7893):1393–1394. doi: 10.1016/s0140-6736(74)92272-7. [DOI] [PubMed] [Google Scholar]
  6. Chandra R. K. Reduced secretory antibody response to live attenuated measles and poliovirus vaccines in malnourished children. Br Med J. 1975 Jun 14;2(5971):583–585. doi: 10.1136/bmj.2.5971.583. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Chandra R. K., Sharma S., Bhujwala R. A. Effect of acute and chronic starvation on plaque forming cell response in mice. Indian J Med Res. 1973 Jan;61(1):93–97. [PubMed] [Google Scholar]
  8. Coombs R. R., Jonas W. E., Lachmann P. J., Feinstein A. Detection of IgA antibodies by the red cell linked antigen-antiglobulin reaction: antibodies in the sera of infants to milk proteins. Int Arch Allergy Appl Immunol. 1965;27(6):321–337. doi: 10.1159/000229616. [DOI] [PubMed] [Google Scholar]
  9. Davies D. F., Johnson A. P., Rees B. W., Elwood P. C., Abernethy M. Food antibodies and myocardial infarction. Lancet. 1974 May 25;1(7865):1012–1014. doi: 10.1016/s0140-6736(74)90415-2. [DOI] [PubMed] [Google Scholar]
  10. Drucker M. M., Russell A. Milk antibodies in familial dysautonomia. Pediatrics. 1969 Aug;44(2):265–268. [PubMed] [Google Scholar]
  11. Ferguson A., Carswell F. Precipitins to dietary proteins in serum and upper intestinal secretions of coeliac children. Br Med J. 1972 Jan 8;1(5792):75–77. doi: 10.1136/bmj.1.5792.75. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. GOLD E., ADELSON L., GODEK G. K. THE ROLE OF ANTIBODY TO COW'S MILK PROTEINS IN THE SUDDEN DEATH SYNDROME. Pediatrics. 1964 Apr;33:541–545. [PubMed] [Google Scholar]
  13. GRUSKAY F. L., COOKE R. E. The gastrointestinal absorption of unaltered protein in normal infants and in infants recovering from diarrhea. Pediatrics. 1955 Dec;16(6):763–769. [PubMed] [Google Scholar]
  14. HEINER D. C., SEARS J. W., KNIKER W. T. Multiple precipitins to cow's milk in chronic respiratory disease. A syndrome including poor growth, gastrointestinal symptoms, evidence of allergy, iron deficiency anemia, and pulmonary hemosiderosis. Am J Dis Child. 1962 May;103:634–654. [PubMed] [Google Scholar]
  15. HOLLAND N. H., HONG R., DAVIS N. C., WEST C. D. Significance of precipitating antibodies to milk proteins in the serum of infants and children. J Pediatr. 1962 Aug;61:181–195. doi: 10.1016/s0022-3476(62)80252-2. [DOI] [PubMed] [Google Scholar]
  16. Hunter A., Feinstein A., Coombs R. R. Immunoglobulin class of antibodies to cow's milk casein in infant sera and evidence for low molecular weight IgM antibodies. Immunology. 1968 Sep;15(3):381–388. [PMC free article] [PubMed] [Google Scholar]
  17. Kletter B., Gery I., Freier S., Davies A. M. Immune responses of normal infants to cow milk. I. Antibody type and kinetics of production. Int Arch Allergy Appl Immunol. 1971;40(4-5):656–666. doi: 10.1159/000230447. [DOI] [PubMed] [Google Scholar]
  18. Matthews T. S., Soothill J. F. Complement activation after milk feeding in children with cow's milk allergy. Lancet. 1970 Oct 31;2(7679):893–895. doi: 10.1016/s0140-6736(70)92068-4. [DOI] [PubMed] [Google Scholar]
  19. NELSON T. L. SPONTANEOUSLY OCCURRING MILK ANTIBODIES IN MONGOLOIDS. Am J Dis Child. 1964 Nov;108:494–498. doi: 10.1001/archpedi.1964.02090010496008. [DOI] [PubMed] [Google Scholar]
  20. Passwell J. H., Steward M. W., Soothill J. F. The effects of protein malnutrition on macrophage function and the amount and affinity of antibody response. Clin Exp Immunol. 1974 Jul;17(3):491–495. [PMC free article] [PubMed] [Google Scholar]
  21. Ratnakar K. S., Mathur M., Ramalingaswami V., Deo M. G. Phagocytic function of reticuloendothelial system in protein deficiency--a study in rhesus monkeys using 32 P-labeled E. coli. J Nutr. 1972 Sep;102(9):1233–1237. doi: 10.1093/jn/102.9.1233. [DOI] [PubMed] [Google Scholar]
  22. Saba T. M., Di Luzio N. R. Involvement of the opsonic system in starvation induced depression of the reticuloendothelial system. Proc Soc Exp Biol Med. 1968 Jul;128(3):869–875. doi: 10.3181/00379727-128-33145. [DOI] [PubMed] [Google Scholar]
  23. Selvaraj R. J., Bhat K. S. [Metabolic and bactericidal activities of leukocytes in protein-calorie malnutrition]. Am J Clin Nutr. 1972 Feb;25(2):166–174. doi: 10.1093/ajcn/25.2.166. [DOI] [PubMed] [Google Scholar]
  24. Seth V., Chandra R. K. Opsonic activity, phagocytosis, and bactericidal capacity of polymorphs in undernutrition. Arch Dis Child. 1972 Apr;47(252):282–284. doi: 10.1136/adc.47.252.282. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Smythe P. M., Brereton-Stiles G. G., Grace H. J., Mafoyane A., Schonland M., Coovadia H. M., Loening W. E., Parent M. A., Vos G. H. Thymolymphatic deficiency and depression of cell-mediated immunity in protein-calorie malnutrition. Lancet. 1971 Oct 30;2(7731):939–943. doi: 10.1016/s0140-6736(71)90267-4. [DOI] [PubMed] [Google Scholar]
  26. TAYLOR K. B., TRUELOVE S. C., WRIGHT R. SEROLOGIC REACTIONS TO GLUTEN AND COW'S MILK PROTEINS IN GASTROINTESTINAL DISEASE. Gastroenterology. 1964 Feb;46:99–108. [PubMed] [Google Scholar]
  27. Triger D. R., Wright R. Hyperglobulinaemia in liver disease. Lancet. 1973 Jun 30;1(7818):1494–1496. doi: 10.1016/s0140-6736(73)91827-8. [DOI] [PubMed] [Google Scholar]

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