Skip to main content
PMC home page
Archives of Disease in Childhood logoLink to Archives of Disease in Childhood
. 1975 Jul;50(7):535–538. doi: 10.1136/adc.50.7.535

Effect of salbutamol in infants with wheezy bronchitis.

M Radford
PMCID: PMC1544602  PMID: 1167065

Abstract

Using the technique of whole body plethysmography, lung mechanics were measured in a group of infants with wheezy bronchitis. Compared with a group of normal infants previously studied, airway resistance and thoracic gas volume were found to be raised. Nebulized salbutamol was then administered and measurements were repeated when it was found that there was no objective improvement. It is concluded that salbutamol may not be an effective form of treatment of wheezy bronchitis in young infants and the reasons for this are discussed.

Full text

PDF
535

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aherne W., Bird T., Court S. D., Gardner P. S., McQuillin J. Pathological changes in virus infections of the lower respiratory tract in children. J Clin Pathol. 1970 Feb;23(1):7–18. doi: 10.1136/jcp.23.1.7. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Bau S. K., Aspin N., Wood D. E., Levison H. The measurement of fluid deposition in humans following mist tent therapy. Pediatrics. 1971 Oct;48(4):605–612. [PubMed] [Google Scholar]
  3. COOK C. D., HELLIESEN P. J., KULCZYCKI L., BARRIE H., FRIEDLANDER L., AGATHON S., HARRIS G. B., SHWACHMAN H. Studies of respiratory physiology in children. II. Lung volumes and mechanics of respiration in 64 patients with cystic fibrosis of the pancreas. Pediatrics. 1959 Aug;24(2):181–193. [PubMed] [Google Scholar]
  4. Choo-Kang Y. F., Parker S. S., Grant I. W. Response of asthmatics to isoprenaline and salbutamol aerosols administered by intermittent positive-pressure ventilation. Br Med J. 1970 Nov 21;4(5733):465–468. doi: 10.1136/bmj.4.5733.465. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. DUBOIS A. B., BOTELHO S. Y., COMROE J. H., Jr A new method for measuring airway resistance in man using a body plethysmograph: values in normal subjects and in patients with respiratory disease. J Clin Invest. 1956 Mar;35(3):327–335. doi: 10.1172/JCI103282. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. DUBOIS A. B., BRODY A. W., LEWIS D. H., BURGESS B. F., Jr Oscillation mechanics of lungs and chest in man. J Appl Physiol. 1956 May;8(6):587–594. doi: 10.1152/jappl.1956.8.6.587. [DOI] [PubMed] [Google Scholar]
  7. Elderkin F. M., Gardner P. S., Turk D. C., White A. C. Aetiology and management of bronchiolitis and pneumonia in childhood. Br Med J. 1965 Sep 25;2(5464):722–727. doi: 10.1136/bmj.2.5464.722. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. HOLLAND W. W., COLLEY J. R., BARRACLOUGH M. A. Measurement of respiratory effort and assessment of a method of treating lower-respiratory-tract infections in small children. Lancet. 1960 Nov 26;2(7161):1166–1167. doi: 10.1016/s0140-6736(60)92355-2. [DOI] [PubMed] [Google Scholar]
  9. Howlett G. Lung mechanics in normal infants and infants with congenital heart disease. Arch Dis Child. 1972 Oct;47(255):707–715. doi: 10.1136/adc.47.255.707. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. König P., Godfrey S., Abrahamov A. Exercise-induced bronchial lability in children with a history of wheezy bronchitis. Arch Dis Child. 1972 Aug;47(254):578–580. doi: 10.1136/adc.47.254.578. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Matsuba K., Thurlbeck W. M. A morphometric study of bronchial and bronchiolar walls in children. Am Rev Respir Dis. 1972 Jun;105(6):908–913. doi: 10.1164/arrd.1972.105.6.908. [DOI] [PubMed] [Google Scholar]
  12. Meisner P., Hugh-Jones P. Pulmonary function in bronchial asthma. Br Med J. 1968 Feb 24;1(5590):470–475. doi: 10.1136/bmj.1.5590.470. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Phelan P. D., Williams H. E. Sympathomimetic drugs in acute viral bronchiolitis. Their effect on pulmonary resistance. Pediatrics. 1969 Oct;44(4):493–497. [PubMed] [Google Scholar]
  14. REYNOLDS E. O., COOK C. D. THE TREATMENT OF BRONCHIOLITIS. J Pediatr. 1963 Dec;63:1205–1207. doi: 10.1016/s0022-3476(63)80215-2. [DOI] [PubMed] [Google Scholar]
  15. Radford M. Measurement of airway resistance and thoracic gas volume in infancy. Arch Dis Child. 1974 Aug;49(8):611–615. doi: 10.1136/adc.49.8.611. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Riding W. D., Chatterjee S. S., Dinda P. Clinical trial of a new B-adrenergic stimulant in asthma. Br J Clin Pract. 1969 May;23(5):217–219. [PubMed] [Google Scholar]
  17. Rooney J. C., Williams H. E. The relationship between proved viral bronchiolitis and subsequent wheezing. J Pediatr. 1971 Nov;79(5):744–747. doi: 10.1016/s0022-3476(71)80385-2. [DOI] [PubMed] [Google Scholar]
  18. WRIGHT F. H., BEEM M. O. DIAGNOSIS AND TREATMENT: MANAGEMENT OF ACUTE VIRAL BRONCHIOLITIS IN INFANCY. Pediatrics. 1965 Feb;35:334–337. [PubMed] [Google Scholar]
  19. Williams H., McNicol K. N. Prevalence, natural history, and relationship of wheezy bronchitis and asthma in children. An epidemiological study. Br Med J. 1969 Nov 8;4(5679):321–325. doi: 10.1136/bmj.4.5679.321. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Wohl M. E., Stigol L. C., Mead J. Resistance of the total respiratory system in healthy infants and infants with bronchiolitis. Pediatrics. 1969 Apr;43(4):495–509. [PubMed] [Google Scholar]

Articles from Archives of Disease in Childhood are provided here courtesy of BMJ Publishing Group

RESOURCES