Skip to main content
PMC home page
Archives of Disease in Childhood logoLink to Archives of Disease in Childhood
. 1975 Jul;50(7):522–525. doi: 10.1136/adc.50.7.522

Thyrotrophin estimation in diagnosis and treatment of childhood thyroid disorders.

D Jackson, M Vanderschueren-Lodeweyckx, D B Grant
PMCID: PMC1544607  PMID: 810094

Abstract

Serum thyrotrophin (TSH) was estimated by double-antibody radioimmunoassay in 200 children aged 2 months to 16 years with normal thyroid function. There was no apparent variation in TSH with age or sex and only 4 children had TSH levels greater than 5 muU/ml. High TSH values were obtained in 9 children with primary hypothyroidism, in 3 children with thyroiditis, and in one girl with a lingual thyroid. Moderately raised TSH was found in 3 girls with thyroiditis, 2 brothers with goitres due to enzyme defect, and a girl with an ectopic thyroid. In one girl with a defect of iodine organification and in 3 boys with thyroxine binding globulin deficiency the TSH levels were normal despite very low serum thyroxine values. Serum TSH was also estimated in 20 children during treatment for primary hypothyroidism. 3 of these children showed slightly raised TSH levels despite apparently adequate replacement therapy with L-thyroxine. One girl showed a very high TSH level 3 weeks after treatment had been temporarily withdrawn.

Full text

PDF
522

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Barnes N. D., Hayles A. B., Ryan R. J. Sexual maturation in juvenile hypothyroidism. Mayo Clin Proc. 1973 Dec;48(12):849–856. [PubMed] [Google Scholar]
  2. Chaussain J. L. Dosage de l'hormone thyréotrope sérique par la méthode radio-immunologique: son application à la détermination du taux sérique de l'enfant normal. Ann Endocrinol (Paris) 1971 Nov-Dec;32(6):829–834. [PubMed] [Google Scholar]
  3. Costom B. H., Grumbach M. M., Kaplan S. L. Effect of thyrotropin-releasing factor on serum thyroid-stimulating hormone. An approach to distinguishing hypothalamic from pituitary forms of idiopathic hypopituitary dwarfism. J Clin Invest. 1971 Oct;50(10):2219–2225. doi: 10.1172/JCI106717. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Golstein-Golaire J., Delange F. Serum thyrotropin level during growth in man. Eur J Clin Invest. 1971 Sep;1(6):405–408. doi: 10.1111/j.1365-2362.1971.tb00549.x. [DOI] [PubMed] [Google Scholar]
  5. Gomez-Pan A., Evered D. C., Hall R. Pituitary-thyroid function in Pendred's syndrome. Br Med J. 1974 Apr 20;2(5911):152–153. doi: 10.1136/bmj.2.5911.152. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Gordin A., Saarinen P., Pelkonen R., Lamberg B. A. Serum thyrotrophin and the response to thyrotrophin releasing hormone in symptomless autoimmune thyroiditis and in borderline and overt hypothyroidism. Acta Endocrinol (Copenh) 1974 Feb;75(2):274–285. doi: 10.1530/acta.0.0750274. [DOI] [PubMed] [Google Scholar]
  7. Grant D. B., Clarke H. G., Putman D. Familial thyroxine-binding globulin deficiency: search for linkage with Xg blood groups. J Med Genet. 1974 Sep;11(3):271–274. doi: 10.1136/jmg.11.3.271. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Greenberg A. H., Czernichow P., Hung W., Shelley W., Winship T., Blizzard R. M. Juvenile chronic lymphocytic thyroiditis: clinical, laboratory and histological correlations. J Clin Endocrinol Metab. 1970 Mar;30(3):293–301. doi: 10.1210/jcem-30-3-293. [DOI] [PubMed] [Google Scholar]
  9. Hall R., Amos J., Ormston B. J. Radioimmunoassay of human serum thyrotrophin. Br Med J. 1971 Mar 13;1(5749):582–585. doi: 10.1136/bmj.1.5749.582. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Harvey R. F., Doniach D. Dyshormonogenetic goitre with high circulating levels of thyroid-stimulating hormone. Proc R Soc Med. 1971 Mar;64(3):299–300. [PMC free article] [PubMed] [Google Scholar]
  11. Hayek A., Maloof F., Crawford J. D. Thyrotropin behavior in thyroid disorders of childhood. Pediatr Res. 1973 Jan;7(1):28–38. doi: 10.1203/00006450-197301000-00005. [DOI] [PubMed] [Google Scholar]
  12. Kulin H. E., Kohler P. O., O'Malley B. W., Odell W. D. Thyroid-stimulating hormone in thyroid dysgenesis. J Pediatr. 1967 Nov;71(5):714–717. doi: 10.1016/s0022-3476(67)80209-9. [DOI] [PubMed] [Google Scholar]
  13. Lamberg B. A., Kantero R. L., Saarinen P., Widholm O. Endocrine changes before and after the menarche. IV. Serum thyrotrophin in female adolescents. Acta Endocrinol (Copenh) 1973 Dec;74(4):695–702. doi: 10.1530/acta.0.0740695. [DOI] [PubMed] [Google Scholar]
  14. Malvaux P., Beckers C. Serum thyrotrophin response to thyrotrophin-releasing hormone in normal children and in patients with short stature and various endocrine or genetic diseases. Clin Endocrinol (Oxf) 1973 Jul;2(3):219–225. doi: 10.1111/j.1365-2265.1973.tb00423.x. [DOI] [PubMed] [Google Scholar]
  15. Mayberry W. E., Gharib H., Bilstad J. M., Sizemore G. W. Radioimmunoassay for human thyrotrophin. Clinical value in patients with normal and abnormal thyroid function. Ann Intern Med. 1971 Apr;74(4):471–480. doi: 10.7326/0003-4819-74-4-471. [DOI] [PubMed] [Google Scholar]
  16. Ryness J. The measurement of serum thyroxine in children. J Clin Pathol. 1972 Aug;25(8):726–729. doi: 10.1136/jcp.25.8.726. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Archives of Disease in Childhood are provided here courtesy of BMJ Publishing Group

RESOURCES