Abstract
The hormonal and metabolic response to the first feed of breast milk was studied in 12 infants at 4-6 hours of age. After the feed there was an increase in blood glucose concentration but no changes in the concentrations of lactate, pyruvate, alanine, or ketone bodies. The feed was followed by an increase in the concentrations of plasma insulin, growth hormone, gastrin, and enteroglucagon, but no change in levels of plasma glucagon or gastric inhibitory peptide. Several hormone systems are functionally active at birth and are stimulated by the first feed of milk.
Full text
PDF




Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Albano J. D., Ekins R. P., Maritz G., Turner R. C. A sensitive, precise radioimmunoassay of serum insulin relying on charcoal separation of bound and free hormone moieties. Acta Endocrinol (Copenh) 1972 Jul;70(3):487–509. doi: 10.1530/acta.0.0700487. [DOI] [PubMed] [Google Scholar]
- Asplund K. Effects of postnatal feeding on the functional maturation of pancreatic islet B-cells of neonatal rats. Diabetologia. 1972 Jul;8(3):153–159. doi: 10.1007/BF01212254. [DOI] [PubMed] [Google Scholar]
- Bassett J. M. Early changes in plasma insulin and growth hormone levels after feeding in lambs and adult sheep. Aust J Biol Sci. 1974 Apr;27(2):157–166. doi: 10.1071/bi9740157. [DOI] [PubMed] [Google Scholar]
- Bloom S. R. Hormones of the gastrointestinal tract. Br Med Bull. 1974 Jan;30(1):62–67. doi: 10.1093/oxfordjournals.bmb.a071169. [DOI] [PubMed] [Google Scholar]
- Bloom S. R., Johnston D. I. Failure of glucagon release in infants of diabetic mothers. Br Med J. 1972 Nov 25;4(5838):453–454. doi: 10.1136/bmj.4.5838.453. [DOI] [PMC free article] [PubMed] [Google Scholar]
- CORNBLATH M., PARKER M. L., REISNER S. H., FORBES A. E., DAUGHADAY W. H. SECRETION AND METABOLISM OF GROWTH HORMONE IN PREMATURE AND FULL-TERM INFANTS. J Clin Endocrinol Metab. 1965 Feb;25:209–218. doi: 10.1210/jcem-25-2-209. [DOI] [PubMed] [Google Scholar]
- Falorni A., Fracassini F., Massi-Benedetti F., Maffei S. Glucose metabolism and insulin secretion in the newborn infant. Comparisons between the responses observed the first and seventh day of life to intravenous and oral glucose tolerance tests. Diabetes. 1974 Mar;23(3):172–178. doi: 10.2337/diab.23.3.172. [DOI] [PubMed] [Google Scholar]
- Fiser R. H., Williams P. R., Fisher D. A., DeLameter P. V., Sperling M. A., Oh W. The effect of oral alanine on blood glucose and glucagon in the human newborn infant. Pediatrics. 1975 Jul;56(1):78–81. [PubMed] [Google Scholar]
- Gentz J., Persson B., Kellum M., Bengtsson G., Thorell J. Effect of feeding on intravenous glucose tolerance and insulin response in piglets during the first day of life. Life Sci II. 1971 Feb 8;10(3):137–144. doi: 10.1016/0024-3205(71)90026-9. [DOI] [PubMed] [Google Scholar]
- Hey E. N., Katz G. The optimum thermal environment for naked babies. Arch Dis Child. 1970 Jun;45(241):328–334. doi: 10.1136/adc.45.241.328. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rogers I. M., Davidson D. C., Lawrence J., Ardill J., Buchanan K. D. Neonatal secretion of gastrin and glucagon. Arch Dis Child. 1974 Oct;49(10):796–801. doi: 10.1136/adc.49.10.796. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rogers I. M., Davidson D. C., Lawrence J., Buchanan K. D. Neonatal secretion of secretin. Arch Dis Child. 1975 Feb;50(2):120–122. doi: 10.1136/adc.50.2.120. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Shelley H. J., Bassett J. M., Milner R. D. Control of carbohydrate metabolism in the fetus and newborn. Br Med Bull. 1975 Jan;31(1):37–43. doi: 10.1093/oxfordjournals.bmb.a071239. [DOI] [PubMed] [Google Scholar]
- Turner R. C., Schneeloch B., Paterson P. Changes in plasma growth hormone and insulin of the human foetus following hysterotomy. Acta Endocrinol (Copenh) 1971 Apr;66(4):577–586. doi: 10.1530/acta.0.0660577. [DOI] [PubMed] [Google Scholar]
- Williams P. R., Fiser R. H., Jr, Sperling M. A., Oh W. Effects of oral alanine feeding on blood glucose, plasma glucagon and insulin concentrations in small-for-gestational-age infants. N Engl J Med. 1975 Mar 20;292(12):612–614. doi: 10.1056/NEJM197503202921204. [DOI] [PubMed] [Google Scholar]