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. 1977 Sep;52(9):687–690. doi: 10.1136/adc.52.9.687

Serum complement depression during viral lower respiratory tract illness in cystic fibrosis.

R C Strunk, O F Sieber, L M Taussig, E P Gall
PMCID: PMC1544734  PMID: 921318

Abstract

Cystic fibrosis (CF) patients with viral lower respiratory tract illnesses (LRI) had depressed levels of the third and fourth components of complement, which returned to normal after recovery. There was no clinical evidence of immune complex disease. CF patients with LRI and no virus isolates, CF patients in stable status, and non-CF patients with LRI did not have complement depression. It is postulated that antigen-antibody complex activation of complement may occur in CF patients with viral LRI.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Conover J. H., Conod E. J., Hirschhorn K. Letter: Complement components in cystic fibrosis. Lancet. 1973 Dec 29;2(7844):1501–1501. doi: 10.1016/s0140-6736(73)92768-2. [DOI] [PubMed] [Google Scholar]
  2. Gaither T. A., Alling D. W., Frank M. M. A new one-step method for the functional assay of the fourth component (C4) of human and guinea pig complement. J Immunol. 1974 Aug;113(2):574–583. [PubMed] [Google Scholar]
  3. Hann S., Holsclaw D. S., Shin H. S. Letter: Complement components in cystic fibrosis. Lancet. 1974 Aug 31;2(7879):520–521. doi: 10.1016/s0140-6736(74)92044-3. [DOI] [PubMed] [Google Scholar]
  4. Mancini G., Carbonara A. O., Heremans J. F. Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry. 1965 Sep;2(3):235–254. doi: 10.1016/0019-2791(65)90004-2. [DOI] [PubMed] [Google Scholar]
  5. McFarlane H., Holzel A., Brenchley P., Allan J. D., Wallwork J. C., Singer B. E., Worsley B. Immune complexes in cystic fibrosis. Br Med J. 1975 Feb 22;1(5955):423–428. doi: 10.1136/bmj.1.5955.423. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Oldstone M. B. Virus neutralization and virus-induced immune complex disease. Virus-antibody union resulting in immunoprotection or immunologic injury--two sides of the same coin. Prog Med Virol. 1975;19:84–119. [PubMed] [Google Scholar]
  7. Polley M. J., Bearn A. G. Cystic fibrosis: current concepts. J Med Genet. 1974 Sep;11(3):249–252. doi: 10.1136/jmg.11.3.249. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. STEIN A. A., MANLAPAS F. C., SOIKE K. F., PATTERSON P. R. SPECIFIC ISOANTIBODIES IN CYSTIC FIBROSIS. A STUDY OF SERUM AND BRONCHIAL MUCUS. J Pediatr. 1964 Oct;65:495–500. doi: 10.1016/s0022-3476(64)80285-7. [DOI] [PubMed] [Google Scholar]
  9. Taussig L. M., Kattwinkel J., Friedewald W. T., Di Sant'Agnese P. A. A new prognostic score and clinical evaluation system for cystic fibrosis. J Pediatr. 1973 Mar;82(3):380–390. doi: 10.1016/s0022-3476(73)80110-6. [DOI] [PubMed] [Google Scholar]
  10. Wallwork J. C., Brenchley P., McCarthy J., Allan J. D., Moss D., Ward A. M., Holzel A., Williams R. F., McFarlane H. Some aspects of immunity in patients with cystic fibrosis. Clin Exp Immunol. 1974 Nov;18(3):303–320. [PMC free article] [PubMed] [Google Scholar]

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