Abstract
A study of 893 births was undertaken to determine the incidence of prolonged neonatal jaundice. 55% of these babies were breast feeding on discharge from the maternity hospital. Jaundice lasting for 3 weeks or more was found in 12 breast-fed term babies (2-4% of all breast-fed babies), and in no bottle-fed infant. 3 of the jaundiced babies gained weight poorly in the first 3 weeks of life, but after that age failure to thrive was not associated with the prolonged jaundice. The hyperbilirubinaemia, which persisted in 11 infants from between 21 to 80 days (mean 39 days), was due to elevations in both conjugated and unconjugated fractions.
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Selected References
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- ARIAS I. M., GARTNER L. M., SEIFTER S., FURMAN M. PROLONGED NEONATAL UNCONJUGATED HYPERBILIRUBINEMIA ASSOCIATED WITH BREAST FEEDING AND A STEROID, PREGNANE-3(ALPHA), 20(BETA)-DIOL, IN MATERNAL MILK THAT INHIBITS GLUCURONIDE FORMATION IN VITRO. J Clin Invest. 1964 Nov;43:2037–2047. doi: 10.1172/JCI105078. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Arthur L. J., Bevan B. R., Holton J. B. Breast milk bilirubin conjugation inhibitors in neonatal hyperbilirubinaemia. Arch Dis Child. 1972 Dec;47(256):984–984. doi: 10.1136/adc.47.256.984. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bevan B. R., Holton J. B., Lathe G. H. The effect of pregnanediol and pregnanediol glucuronide on bilirubin conjugation by rat liver slices. Clin Sci. 1965 Oct;29(2):353–361. [PubMed] [Google Scholar]
- Foliot A., Ploussard J. P., Housset E., Christoforov Breast milk jaundice: in vitro inhibition of rat liver bilirubin-uridine diphosphate glucuronyltransferase activity and Z protein-bromosulfophthalein binding by human breast milk. Pediatr Res. 1976 Jun;10(6):594–598. doi: 10.1203/00006450-197606000-00007. [DOI] [PubMed] [Google Scholar]
- Hargreaves T., Piper R. F. Breast milk jaundice. Effect of inhibitory breast milk and 3 alpha, 20 abeta-pregnanediol on glucuronyl transferase. Arch Dis Child. 1971 Apr;46(246):195–198. doi: 10.1136/adc.46.246.195. [DOI] [PMC free article] [PubMed] [Google Scholar]
- NEWMAN A. J., GROSS S. HYPERBILIRUBINEMIA IN BREAST-FED INFANTS. Pediatrics. 1963 Dec;32:995–1001. [PubMed] [Google Scholar]
- Ramos A., Silverberg M., Stern L. Pregnanediols and neonatal hyperbilirubinemia. Am J Dis Child. 1966 Apr;111(4):353–356. doi: 10.1001/archpedi.1966.02090070051003. [DOI] [PubMed] [Google Scholar]