Skip to main content
Archives of Disease in Childhood logoLink to Archives of Disease in Childhood
. 1978 Jul;53(7):532–535. doi: 10.1136/adc.53.7.532

At what age do bronchodilator drugs work?

W Lenney, A D Milner
PMCID: PMC1544978  PMID: 686789

Abstract

Using a modification of the forced oscillation technique we have measured respiratory resistance before and after nebulised salbutamol therapy in 32 wheezing children aged 7 months to 3 years 7 monts. 12 of the children were also studied in a total body plethysmograph. No child under 18 months of aged showed a greater than 5% fall in resistance or any fall in thoracic gas volume. In contrast, 18 of 20 children over 20 months of age showed a fall in resistance greater than 20%.

Full text

PDF
532

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Cogswell J. J. Forced oscillation technique for determination of resistance to breathing in children. Arch Dis Child. 1973 Apr;48(4):259–266. doi: 10.1136/adc.48.4.259. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. DUBOIS A. B., BOTELHO S. Y., BEDELL G. N., MARSHALL R., COMROE J. H., Jr A rapid plethysmographic method for measuring thoracic gas volume: a comparison with a nitrogen washout method for measuring functional residual capacity in normal subjects. J Clin Invest. 1956 Mar;35(3):322–326. doi: 10.1172/JCI103281. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. DUBOIS A. B., BOTELHO S. Y., COMROE J. H., Jr A new method for measuring airway resistance in man using a body plethysmograph: values in normal subjects and in patients with respiratory disease. J Clin Invest. 1956 Mar;35(3):327–335. doi: 10.1172/JCI103282. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. DUBOIS A. B., BRODY A. W., LEWIS D. H., BURGESS B. F., Jr Oscillation mechanics of lungs and chest in man. J Appl Physiol. 1956 May;8(6):587–594. doi: 10.1152/jappl.1956.8.6.587. [DOI] [PubMed] [Google Scholar]
  5. Doershuk C. F., Downs T. D., Matthews L. W., Lough M. D. A method for ventilatory measurements in subjects 1 month--5 years of age: Normal results and observations in disease. Pediatr Res. 1970 Mar;4(2):165–174. doi: 10.1203/00006450-197003000-00007. [DOI] [PubMed] [Google Scholar]
  6. Lenney W., Milner A. D. Recurrent wheezing in the preschool child. Arch Dis Child. 1978 Jun;53(6):468–473. doi: 10.1136/adc.53.6.468. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Radford M. Effect of salbutamol in infants with wheezy bronchitis. Arch Dis Child. 1975 Jul;50(7):535–538. doi: 10.1136/adc.50.7.535. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Radford M. Measurement of airway resistance and thoracic gas volume in infancy. Arch Dis Child. 1974 Aug;49(8):611–615. doi: 10.1136/adc.49.8.611. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Rutter N., Milner A. D., Hiller E. J. Effect of bronchodilators on respiratory resistance in infants and young children with bronchiolitis and wheezy bronchitis. Arch Dis Child. 1975 Sep;50(9):719–722. doi: 10.1136/adc.50.9.719. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Stocks J., Levy N. M., Godfrey S. A new apparatus for the accurate measurement of airway resistance in infancy. J Appl Physiol Respir Environ Exerc Physiol. 1977 Jul;43(1):155–159. doi: 10.1152/jappl.1977.43.1.155. [DOI] [PubMed] [Google Scholar]
  11. Williams H., McNicol K. N. Prevalence, natural history, and relationship of wheezy bronchitis and asthma in children. An epidemiological study. Br Med J. 1969 Nov 8;4(5679):321–325. doi: 10.1136/bmj.4.5679.321. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Woolcock A. J., Read J. Lung volumes in exacerbations of asthma. Am J Med. 1966 Aug;41(2):259–273. doi: 10.1016/0002-9343(66)90021-0. [DOI] [PubMed] [Google Scholar]

Articles from Archives of Disease in Childhood are provided here courtesy of BMJ Publishing Group

RESOURCES