Skip to main content
Archives of Disease in Childhood logoLink to Archives of Disease in Childhood
. 1979 Jan;54(1):1–6. doi: 10.1136/adc.54.1.1

Intellectual performance in children after circulatory arrest with profound hypothermia in infancy.

D F Dickinson, J E Sambrooks
PMCID: PMC1545188  PMID: 420516

Abstract

38 children were assessed 22 months to 6 years after open heart surgery using circulatory arrest with deep hypothermia. The mean IQ of the group was 99.2 (SD 19.5). No correlation was found between IQ and the age or weight at operation or the duration of circulatory arrest. The results suggest that the technique gives effective protection to the brain during periods of circulatory arrest for up to 60 minutes.

Full text

PDF
1

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aguilar M. J., Gerbode F., Hill J. D. Neuropathologic complications of cardiac surgery. J Thorac Cardiovasc Surg. 1971 May;61(5):676–685. [PubMed] [Google Scholar]
  2. BJORK V. O., HULTQUIST G. Contraindications to profound hypothermia in open-heart surgery. J Thorac Cardiovasc Surg. 1962 Jul;44:1–13. [PubMed] [Google Scholar]
  3. Baffes T. G. Total body perfusion in infants and small children for open heart surgery. J Pediatr Surg. 1968 Oct;3(5):551–560. doi: 10.1016/0022-3468(68)90105-x. [DOI] [PubMed] [Google Scholar]
  4. Belsey R. H., Dowlatshahi K., Keen G., Skinner D. B. Profound hypothermia in cardiac surgery. J Thorac Cardiovasc Surg. 1968 Oct;56(4):497–509. [PubMed] [Google Scholar]
  5. Ching E., DuShane J. W., McGoon D. C., Danielson G. K. Total correction of cardiac anomalies in infancy using extracorporeal circulation. Surgical consideration and results of operation. J Thorac Cardiovasc Surg. 1971 Jul;62(1):117–124. [PubMed] [Google Scholar]
  6. GILMAN S. CEREBRAL DISORDERS AFTER OPEN-HEART OPERATIONS. N Engl J Med. 1965 Mar 11;272:489–498. doi: 10.1056/NEJM196503112721001. [DOI] [PubMed] [Google Scholar]
  7. Haka-Ikse K., Blackwood M. J., Steward D. J. Psychomotor development of infants and children after profound hypothermia during surgery for congenital heart disease. Dev Med Child Neurol. 1978 Feb;20(1):62–70. doi: 10.1111/j.1469-8749.1978.tb15181.x. [DOI] [PubMed] [Google Scholar]
  8. Hallman G. L., Cooley D. A. Cardiovascular surgery in newborn infants: results in 1,050 patients less than one year old. Ann Surg. 1971 Jun;173(6):1007–1012. doi: 10.1097/00000658-197106010-00019. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Hikasa Y., Shirotani H., Mori C., Kamiya T., Asawa Y. Open heart surgery in infants with an aid of hypothermic anesthesia. Nihon Geka Hokan. 1967 Jul 1;36(4):495–508. [PubMed] [Google Scholar]
  10. Hägerdal M., Harp J., Nilsson L., Siesjö B. K. The effect of induced hypothermia upon oxygen consumption in the rat brain. J Neurochem. 1975 Feb;24(2):311–316. doi: 10.1111/j.1471-4159.1975.tb11881.x. [DOI] [PubMed] [Google Scholar]
  11. Javid H., Tufo H. M., Najafi H., Dye W. S., Hunter J. A., Julian O. C. Neurological abnormalities following open-heart surgery. J Thorac Cardiovasc Surg. 1969 Oct;58(4):502–509. [PubMed] [Google Scholar]
  12. Lassen N. A. Control of cerebral circulation in health and disease. Circ Res. 1974 Jun;34(6):749–760. doi: 10.1161/01.res.34.6.749. [DOI] [PubMed] [Google Scholar]
  13. Linde L. M., Rasof B., Dunn O. J. Mental development in congenital heart disease. J Pediatr. 1967 Aug;71(2):198–203. doi: 10.1016/s0022-3476(67)80072-6. [DOI] [PubMed] [Google Scholar]
  14. Messmer B. J., Schallberger U., Gattiker R., Senning A. Psychomotor and intellectual development after deep hypothermia and circulatory arrest in early infancy. J Thorac Cardiovasc Surg. 1976 Oct;72(4):495–502. [PubMed] [Google Scholar]
  15. Mohri H., Dillard D. H., Crawford E. W., Martin W. E., Merendino K. A. Method of surface-induced deep hypothermia for open-heart surgery in infants. J Thorac Cardiovasc Surg. 1969 Aug;58(2):262–270. [PubMed] [Google Scholar]
  16. Mori A., Muraoka R., Yokota Y., Okamoto Y., Ando F., Fukumasu H., Oku H., Ikeda M., Shirotani H., Hikasa Y. Deep hypothermia combined with cardiopulmonary bypass for cardiac surgery in neonates and infants. J Thorac Cardiovasc Surg. 1972 Sep;64(3):422–429. [PubMed] [Google Scholar]
  17. ROSOMOFF H. L., HOLADAY D. A. Cerebral blood flow and cerebral oxygen consumption during hypothermia. Am J Physiol. 1954 Oct;179(1):85–88. doi: 10.1152/ajplegacy.1954.179.1.85. [DOI] [PubMed] [Google Scholar]
  18. Silbert A., Wolff P. H., Mayer B., Rosenthal A., Nadas A. S. Cyanotic heart disease and psychological development. Pediatrics. 1969 Feb;43(2):192–200. [PubMed] [Google Scholar]
  19. Sugimura S., Starr A. Cardiopulmonary bypass in infants under four months of age. J Thorac Cardiovasc Surg. 1977 Jun;73(6):894–899. [PubMed] [Google Scholar]
  20. Sunderland C. O., Matarazzo R. G., Lees M. H., Menashe V. D., Bonchek L. I., Rosenberg J. A., Starr A. Total correction of tetralogy of Fallot in infancy. Postoperative hemodynamic evaluation. Circulation. 1973 Aug;48(2):398–405. doi: 10.1161/01.cir.48.2.398. [DOI] [PubMed] [Google Scholar]
  21. Venugopal P., Olszowka J., Wagner H., Vlad P., Lambert E., Subramanian S. Early correction of congenital heart disease with surface-induced deep hypothermia and circulatory arrest. J Thorac Cardiovasc Surg. 1973 Sep;66(3):375–386. [PubMed] [Google Scholar]

Articles from Archives of Disease in Childhood are provided here courtesy of BMJ Publishing Group

RESOURCES