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. 1979 Mar;54(3):222–225. doi: 10.1136/adc.54.3.222

Lomotil poisoning in children.

J A Curtis, K M Goel
PMCID: PMC1545247  PMID: 434909

Abstract

45 children were admitted to hospital after ingesting varying quantities of diphenoxylate (Lomotil). One died and 44 recovered without any sequelae. Four patients were comatose, 32 were drowsy, and 9 suffered respiratory depression. No correlation was found between ingested dose and the severity of symptoms. Because of its action in rendering the gut atonic, removal of diphenoxylate by gastric lavage is mandatory, even in patients admitted at least 24 hours after drug ingestion. Naloxone is the narcotic antagonist of choice, and should be used in all cases where suspected diphenoxylate poisoning leads to respiratory depression or coma. The use of Lomotil as an antidiarrhoeal agent in children is difficult to justify.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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